Keywords: مهار کننده های دوگانه; erbB4 inhibitors; Antitumor compounds; Inverse virtual screening; Lead repurposing; Dual inhibitors;
مقالات ISI مهار کننده های دوگانه (ترجمه نشده)
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Keywords: مهار کننده های دوگانه; Pyrimidones; Anti-HIV; Integrase inhibitors; Strand transfer; 3â²-processing; Dual inhibitors;
Keywords: مهار کننده های دوگانه; Benzo[h][1,6]naphthyridines; Povarov reaction; Dual inhibitors; AChE PAS binding; AChE midgorge binding
Ligand-based modeling of Akt3 lead to potent dual Akt1/Akt3 inhibitor
Keywords: مهار کننده های دوگانه; Akt1; Akt3; Ligand based analysis; Dual inhibitors; Anticancer;
Design, synthesis, biological evaluation and in vivo testing of dual phosphodiesterase 5 (PDE5) and histone deacetylase 6 (HDAC6)-selective inhibitors for the treatment of Alzheimer's disease
Keywords: مهار کننده های دوگانه; Dual inhibitors; PDE5 inhibition; HDAC6 selective; Alzheimer; Pharmacological tool compound; Tg2576 mice; In-vivo test;
Dueling for dual inhibition: Means to enhance effectiveness of PI3K/Akt/mTOR inhibitors in AML
Keywords: مهار کننده های دوگانه; AML; mTOR; PI3K; Akt; Resistance mechanisms; Dual inhibitors; Rapalogs;
Polysubstituted 4,6-bis(hetero)arylpyrimidines as dual inhibitors of nitric oxide and prostaglandin E2 production
Keywords: مهار کننده های دوگانه; Pyrimidine derivatives; Nitric oxide; Prostaglandin E2; Dual inhibitors; Anti-inflammatory properties;
Original ArticleAn anti-prostate cancer benzofuran-conjugated iridium(III) complex as a dual inhibitor of STAT3 and NF-κB
Keywords: مهار کننده های دوگانه; Benzofuran-conjugated iridium(III) complex; STAT3; NF-κB; Prostate cells; Dual inhibitors;
Isosteroidal alkaloids as potent dual-binding site inhibitors of both acetylcholinesterase and butyrylcholinesterase from the bulbs of Fritillaria walujewii
Keywords: مهار کننده های دوگانه; Alzheimer's disease; Acetylcholinesterase; Butyrylcholinesterase; Dual inhibitors; Isosteroidal alkaloids; Fritillaria walujewii;
Structure-based design, synthesis and in vitro antiproliferative effects studies of novel dual BRD4/HDAC inhibitors
Keywords: مهار کننده های دوگانه; BET; HDAC; Dual inhibitors; Myc; AML;
Synthesis, biological evaluation and docking studies of 2,3-dihydroquinazolin-4(1H)-one derivatives as inhibitors of cholinesterases
Keywords: مهار کننده های دوگانه; 2,3-Dihydroquinazolin-4(1H)-one; Dual inhibitors; Cholinesterases; Alzheimer's disease;
First dual AK/GSK-3β inhibitors endowed with antioxidant properties as multifunctional, potential neuroprotective agents
Keywords: مهار کننده های دوگانه; Antioxidant agents; Glycogen synthase kinase 3 beta (GSK-3β); Adenosine kinase (AK); Dual inhibitors; Molecular docking;
Discovery of novel dual inhibitors against Mdm2 and Mdmx proteins by in silico approaches and binding assay
Keywords: مهار کننده های دوگانه; Dual inhibitors; Mdm2 & Mdmx; Drug design; p53; In silico process; Qualitative SAR;
Do whey protein-derived peptides have dual dipeptidyl-peptidase IV and angiotensin I-converting enzyme inhibitory activities?
Keywords: مهار کننده های دوگانه; Angiotensin I-converting enzyme; Dipeptidyl-peptidase IV; Whey protein hydrolysates; Bioactive peptides; Dual inhibitors
Structure-based optimization leads to the discovery of NSC765844, a highly potent, less toxic and orally efficacious dual PI3K/mTOR inhibitor
Keywords: مهار کننده های دوگانه; Phosphoinositide 3-kinase (PI3K); Mammalian target of rapamycin (mTOR); Dual inhibitors; AnticancerAIBN, α,α′-azoisobutyronitrile; ATP, adenosine triphosphate; DCM, dichloromethane; DMF, dimethyl formamide; DOX, doxorubicin; GPCR, G-protein-coupled recept
Advances in rationally designed dual inhibitors of HIV-1 reverse transcriptase and integrase
Keywords: مهار کننده های دوگانه; HIV; AIDS; Reverse transcriptase; Integrase; Rational drug design; Dual inhibitors;
Diketoacid chelating ligands as dual inhibitors of HIV-1 integration process
Keywords: مهار کننده های دوگانه; Antiviral agents; HIV-1 integrase inhibitors; LEDGF/p75 protein–protein inhibitors; Magnesium complexes; Dual inhibitors; Diketo acid3-P, 3′-processing; AIDS, acquired immunodeficiency syndrome; DKAs, α,β-diketoacids; HAART, highly active antiretroviral t
Design, synthesis and structure-activity relationship studies of morpholino-1H-phenalene derivatives that antagonize Mcl-1/Bcl-2
Keywords: مهار کننده های دوگانه; Dual inhibitors; Hydrogen bond; Apoptosis; Mcl-1; Bcl-2;
Additional acetyl cholinesterase inhibitory property of diaryl pyrazoline derivatives
Keywords: مهار کننده های دوگانه; Acetylcholineesterase; Monoamine oxidase; Dual inhibitors; Docking
Efficient synthesis and 5-LOX/COX-inhibitory activity of some 3-hydroxybenzo[b]thiophene-2-carboxylic acid derivatives
Keywords: مهار کننده های دوگانه; Dual inhibitors; Licofelone; COX-1/2; 5-LOX; Benzothiophene
Berberine derivatives, with substituted amino groups linked at the 9-position, as inhibitors of acetylcholinesterase/butyrylcholinesterase
Keywords: مهار کننده های دوگانه; Berberine derivatives; Dual inhibitors; Acetylcholinesterase; Butyrylcholinesterase; Molecular modeling
Synthesis and biological evaluation of a new series of berberine derivatives as dual inhibitors of acetylcholinesterase and butyrylcholinesterase
Keywords: مهار کننده های دوگانه; Synthesis and biological evaluation; Dual inhibitors; Acetylcholinesterase; Molecular modeling
Anti-inflammatory potential of 2-styrylchromones regarding their interference with arachidonic acid metabolic pathways
Keywords: مهار کننده های دوگانه; 2-Styrylchromones; Cyclooxygenase; 5-Lipoxigenase; Leukotriene B4; Dual inhibitors; Inflammation
Diaryl-dithiolanes and -isothiazoles: COX-1/COX-2 and 5-LOX-inhibitory, OH scavenging and anti-adhesive activities
Keywords: مهار کننده های دوگانه; COX-1/2; 5-LOX; Dual inhibitors; Hydroxyl radical scavenging; Anti-adhesive activities; Leukocyte–endothelial interactions
Investigations concerning the COX/5-LOX inhibiting and hydroxyl radical scavenging potencies of novel 4,5-diaryl isoselenazoles
Keywords: مهار کننده های دوگانه; COX-1/2; 5-LOX; Dual inhibitors; Hydroxyl radical scavenging; Isoselenazoles
Design and synthesis of dual inhibitors of HIV reverse transcriptase and integrase: Introducing a diketoacid functionality into delavirdine
Keywords: مهار کننده های دوگانه; HIV; Dual inhibitors; Reverse transcriptase; Integrase
Design and synthesis of 7-alkoxy-4-heteroarylamino-3-quinolinecarbonitriles as dual inhibitors of c-Src kinase and nitric oxide synthase
Keywords: مهار کننده های دوگانه; Src; iNOS; Dual inhibitors; Anticancer
Identification of phosphodiesterase-1 and 5 dual inhibitors by a ligand-based virtual screening optimized for lead evolution
Keywords: مهار کننده های دوگانه; Phosphodiesterase; PDE-1; PDE-5; Dual inhibitors; Virtual screening; CART; Pharmacophore;
Synthesis and biological evaluation of a new class of acyl derivatives of 3-amino-1-phenyl-4,5-dihydro-1H-pyrazol-5-one as potential dual cyclooxygenase (COX-1 and COX-2) and human lipoxygenase (5-LOX) inhibitors
Keywords: مهار کننده های دوگانه; Cyclooxygenase; Lipoxygenase; Dual inhibitors; Phenidone derivatives;
Synthesis and biological evaluation of new phenidone analogues as potential dual cyclooxygenase (COX-1 and COX-2) and human lipoxygenase (5-LOX) inhibitors
Keywords: مهار کننده های دوگانه; Cyclooxygenase; Lipoxygenase; Dual inhibitors; Phenidone derivatives;