Design and synthesis of novel pyrimido[4,5-b]azepine derivatives as HER2/EGFR dual inhibitors
Keywords: 1H NMR, proton nuclear magnetic resonance; DMF, N,N-dimethylformamide; EGFR, epidermal growth factor receptor; EDC, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; EtOAc, ethyl acetate; EtOH, ethanol; GI, growth inhibitory; HCl, hydrochloric