دانلود مقالات ISI درباره نسبت خروجی + ترجمه فارسی

نقش تانگرتین به عنوان یک افزایش دهنده بالقوه بیوپلاسمیدی برای سیلبیین: مطالعات فارماکوکینتیک و فارماکولوژیک

Role of tangeretin as a potential bioavailability enhancer for silybin: Pharmacokinetic and pharmacological studies

Keywords: نسبت خروجی; AUC; area under the concentration-time curve; AST; aspartate transaminase; ALT; alanine transaminase; BCRP; breast cancer resistance protein; BEI; biliary excretion index; CL/F; oral clearance; Clbiliary; in vitro biliary clearance; ER; Efflux Ratio; LCâ€

دانلود رایگان متن کامل مقاله ISI 37 صفحه سال انتشار : 2018 سفارش ترجمه

حمل و نقل مشتقات کرکومین در یک سلول سلولی کاکو -2

Research paperTransport of curcumin derivatives in Caco-2 cell monolayers

Keywords: نسبت خروجی; AP; apical; BL; basolateral; CB; (1E,4E)-1,5-bis (3-methoxy-4-hydroxy phenyl)-1,4-diene-3-pentanone; Cur; curcumin; DMEM; dulbecco's modified eagle's medium; DMSO; dimethyl sulfoxide; EDTA; ethylenediaminetetraacetic acid; ER; efflux ratio; FBS; fetal

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

The influence of compatibility of Si-Ni decoction with metabolism in intestinal bacteria on transports of toxic diterpenoid alkaloids from processed aconite root across Caco-2 monolayers

Keywords: نسبت خروجی; AD; Decoction of processed aconite root; ALD; Decoction of processed aconite root and honey-processed liquorice; AP; Apical; BCRP; Breast cancer resistance protein; BL; Basolateral; DDAs; Diester-diterpenoid alkaloids; EIC; Extracted ion chromatogram; ER;

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2019 سفارش ترجمه

Characterization of the IPEC-J2 MDR1 (iP-gp) cell line as a tool for identification of P-gp substrates

Keywords: نسبت خروجی; P-glycoprotein; Efflux ratio; ABCB1; MDR1-P-gp inhibitor; Digoxin; Rhodamine 123; Zosuquidar; Monolayer;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2018 سفارش ترجمه

Assessment of HBEC-5i endothelial cell line cultivated in astrocyte conditioned medium as a human blood-brain barrier model for ABC drug transport studies

Keywords: نسبت خروجی; Blood-Brain Barrier; ABC transporters; Efflux ratio; Human in vitro models; Astrocyte conditioned medium;

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2018 سفارش ترجمه

The expected characteristics of an in vitro human Blood Brain Barrier model derived from cell lines, for studying how ABC transporters influence drug permeability

Keywords: نسبت خروجی; Blood-brain-barrier; ABC transporters; in vitro model; Pharmacological model; Drug permeability; Efflux ratio;

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2018 سفارش ترجمه

A systematic review of pharmacokinetic studies on herbal drug Fuzi: Implications for Fuzi as personalized medicine

Keywords: نسبت خروجی; Aconitum carmichaeli Debx.; Aconitum alkaloids; Pharmacokinetics; Herb-drug interactions; Toxicology; Personalized medicine; DMEs; drug-metabolizing enzymes; ETs; efflux transporters; BB; bioavailability barrier; DDAs; diester-diterpene alkaloids; MDAs; m

دانلود رایگان متن کامل مقاله ISI 55 صفحه سال انتشار : 2018 سفارش ترجمه

Abcb1a (P-glycoprotein) limits brain exposure of the anticancer drug candidate seliciclib in vivo in adult mice

Keywords: نسبت خروجی; Seliciclib; Blood-brain barrier; P-glycoproptein; Mice; Microdialysis; BBB; blood brain barrier; ER; efflux ratio; CDK; cyclin-dependent kinase; ABCB1/P-gp/MDR1; ATP-binding Cassette B1/P-glycoprotein/Multidrug Resistance Protein 1; CSF; arteficial cerebr

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2017 سفارش ترجمه

P-Glycoprotein in skin contributes to transdermal absorption of topical corticosteroids

Keywords: نسبت خروجی; P-gp; P-glycoprotein; BCRP; breast cancer resistance protein; SC; stratum corneum; ABC; ATP-binding cassette; MDR1; multidrug resistance 1; MDCK II; Madin-Darby canine kidney II; BL; basal; AP; apical; ER; efflux ratio; Papp; apparent permeability coeffic

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Validation of UHPLC-MS/MS methods for the determination of kaempferol and its metabolite 4-hydroxyphenyl acetic acid, and application to in vitro blood-brain barrier and intestinal drug permeability studies

Keywords: نسبت خروجی; 4-HPAA; 4-hydroxyphenyl acetic acid; ACN; acetonitrile; BSA; bovine serum albumin; Cal; calibrator; CCl; cell layer capacitance; CNS; central nervous system; CV%; coefficient of variation; CPT-cAMP; 8-(4-chlorophenylthio)-adenosine-3′,5′-cyclic monoph

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Research paperEffects of herbal drugs in Mahuang decoction and their main components on intestinal transport characteristics of Ephedra alkaloids evaluated by a Caco-2 cell monolayer model

Keywords: نسبت خروجی; TCM; traditional Chinese medicine; MHP; multi-herb prescription; LEP; l-ephedrine; DPEP; d-pseudoephedrine; LMEP; l-methylephedrine; P-gp; P-glycoprotein; ER; efflux ratio; AP; apical; BL; basolateral; Papp; apparent permeability; PAB; permeability from A

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Establishment of Optimized MDCK Cell Lines for Reliable Efflux Transport Studies

Keywords: نسبت خروجی; ABC transporter; P‐glycoprotein; MDCK; Cell lines; homogenous population; PCR; bidirectional transport assays; Pgp; P‐glycoprotein; MDCK; Madin‐Darby canine kidney cell line; ABC transporters; ATP‐binding cassette transporters; ER; efflux ratio; N

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Transport of ginkgolides with different lipophilicities based on an hCMEC/D3 cell monolayer as a blood–brain barrier cell model

Keywords: نسبت خروجی; Transport; BBB; Ginkgolide; hCMEC/D3 cell; Apparent permeability coefficients; Efflux ratio; Lipophilicity

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Kinase domain inhibition of leucine rich repeat kinase 2 (LRRK2) using a [1,2,4]triazolo[4,3-b]pyridazine scaffold

Keywords: نسبت خروجی; AD; Alzheimer's disease; ANK; ankyrin repeat domain; ARM; armadillo repeat domain; AUC; area under the curve; BA; brain availability; BBB; blood brain barrier; BCRP; breast cancer related protein; BI; brain impairment; CSD; Cambridge Structural Database

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Accelerated Caco-2 cell permeability model for drug discovery

Keywords: نسبت خروجی; Drug permeability; Caco-2 cells; P-glycoprotein; Puromycin; Accelerated model; Efflux ratio; Drug discovery

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Evaluation of various PAMPA models to identify the most discriminating method for the prediction of BBB permeability

Keywords: نسبت خروجی; Permeability; Solubility; PAMPA; Caco-2; Efflux ratio; Log BB; Blood–brain barrier

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

P-glycoprotein and cytochrome P450 3A4 involvement in risperidone transport using an in vitro Caco-2/TC7 model and an in vivo model

Keywords: نسبت خروجی; ab; apical to basolateral; AQ; absorptive quotient; AUCT; area under the curve; ba; basolateral to apical; ClR; renal clearance; Cmax; maximum plasma concentration; CYP; cytochrome P450; ER; efflux ratio; F; fraction not metabolised; FA; fraction absorbed

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2007 سفارش ترجمه

Modulation of drug transport by selected flavonoids: Involvement of P-gp and OCT?

Keywords: نسبت خروجی; OCT; organic cation transporter; P-gp; P-glycoprotein; MDR; multidrug resistance; TEA; tetraethylammoniumbromide; MES; 2-(N-morpholino)-ethanesulfonic acid; TEER; transepithelial electrical resistance; DMEM; Dulbecco's modified eagle medium; FBS; fetal

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2005 سفارش ترجمه