Keywords: الکتریک; MRM; multiple reaction monitoring; iNOS; inducible Nitric Oxide Synthase (NOS2); LOQ; limit of quantification; BME; β-mercaptoethanol; NO2-FA; nitrated fatty acids; CLA; octadeca-(9Z,11E)-dienoic acid; NO2-CLA; (mixture of 9-NO2-CLA [9-nitro-octadeca-9,1
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Keywords: الکتریک; ALD; alcoholic liver disease; E-APH; (1E)-acrylaldehyde phthalazin-1-ylhydrazone; CTT; carbonyl-trapping threshold; 3-HPMA; 3-hydroxypropyl mercapturic acid; HSAB; hard-soft acid-base; LDE(s); lipid-derived electrophile(s); LPO; lipid peroxidation; MEC; m
Keywords: الکتریک; DVSF; divinyl sulfone; ROS; reactive oxygen species; GSH; glutathione; TAP; tandom affinity purification; GFP; green fluorescent protein; TBHP; tert-butyl hydroperoxide; WB; Western blot; GSSG; oxidized glutathione; Thiol; Disulfide; Electrophile; Cross-l
Keywords: الکتریک; Nitro compounds; Natural products; Pharmaceuticals; Stereoselective synthesis; Organocatalysis; Metal catalysis; Nitronates; Nitrile oxides; AIBN; azobisisobutyronitrile; AZADO; 2-azaadamantane-N-oxyl; 9-BBN; 9-borabicyclo[3.3.1]nonane; BINAP; 2,2â²-bis(
Keywords: الکتریک; Lanthanum; Diaryl ketone; Electrophile;
Keywords: الکتریک; Deprotonation; Nucleophile; Transmetalation; Electrophile; Bisaddition; Antimicrobial screening
Keywords: الکتریک; 15d-PGJ2; 15-deoxy-Î12,14-prostaglandin J2; 4-HNE; 4-hydroxynonenal; bt-15d-PGJ2; biotin 15-deoxy-Î12,14-prostaglandin J2; BD-15d-PGJ2; BODIPY FL-15-deoxy-Î12,14-prostaglandin J2; DNA; deoxyribonucleic acid; DNPH; dinitrophenylhydrazine; Ep; electrophi
Keywords: الکتریک; Catalysis; Glutathione; Enzyme; Redox; Thiol; Electrophile;
Synthesis of an electrophilic keto-tetraene 15-oxo-Lipoxin A4 methyl ester via a MIDA boronate
Keywords: الکتریک; Eicosanoid; Electrophile; Palladium-catalyzed coupling; MIDA boronate;
Brain ischemic preconditioning protects against ischemic injury and preserves the blood-brain barrier via oxidative signaling and Nrf2 activation
Keywords: الکتریک; Stroke; Neuroprotection; Ischemic tolerance; Electrophile; Lipid peroxidation; VE-cadherin; Conditioning;
Is it worth expending energy to convert biliverdin into bilirubin?
Keywords: الکتریک; Bilirubin; Biliverdin; Michael reaction acceptor; Electrophile; Kelch-like ECH-associated protein 1; Nuclear factor-erythroid 2 (NF-E2) p45-related factor 2; Biliverdin reductase;
Keap1 as the redox sensor of the antioxidant response
Keywords: الکتریک; Thiol; Nrf2; Reactive oxygen species; Electrophile;
Bipyridine carbaldehydes as electrophiles in the Morita-Baylis-Hillman reaction: synthesis of highly functionalized bipyridyl ligands and a macrocycle
Keywords: الکتریک; MBH reaction; Bipyridine; Electrophile; Pyridine-N-oxide; Spiro pyrrolidine oxindole;
Inhibition of the HIF1α-p300 interaction by quinone- and indandione-mediated ejection of structural Zn(II)
Keywords: الکتریک; Hypoxia; HIF; p300/CBP; Zinc ejection; Electrophile; Quinone;
Role of 8-nitro-cGMP and its redox regulation in cardiovascular electrophilic signaling
Keywords: الکتریک; Reactive oxygen species; Electrophile; Nucleophile; G protein; Cardiovascular remodeling;
Dual anti-oxidant and anti-inflammatory actions of the electrophilic cyclooxygenase-2-derived 17-oxo-DHA in lipopolysaccharide- and cigarette smoke-induced inflammation
Keywords: الکتریک; Omega-3 fatty acid; Electrophile; Cigarette smoke; Inflammation; Oxidative stress
Oxidative stress-mediated aldehyde adduction of GRP78 in a mouse model of alcoholic liver disease: functional independence of ATPase activity and chaperone function
Keywords: الکتریک; 4-HNE; 4-ONE; HSP; Electrophile; Alcoholic liver disease; Protein oxidation; Free radicals;
Interaction of adenanthin with glutathione and thiol enzymes: Selectivity for thioredoxin reductase and inhibition of peroxiredoxin recycling
Keywords: الکتریک; APL; acute promyelocytic leukemia; DTNB; dithiobis-2-nitrobenzoic acid: DTPA, diethylenetriaminepentaacetic acid; NEM; N-ethylmaleimide; Prx; peroxiredoxin.; Peroxiredoxin; Electrophile; Thioredoxin reductase; Glutaredoxin; Adenanthin; Glutathione; Glutat
Covalent inhibition of SUMO and ubiquitin-specific cysteine proteases by an in situ thiol-alkyne addition
Keywords: الکتریک; Posttranslational modification; Cysteine peptidase; Suicide inhibitor; Catalytic triad; Electrophile;
Caffeic acid phenethyl ester activation of Nrf2 pathway is enhanced under oxidative state: Structural analysis and potential as a pathologically targeted therapeutic agent in treatment of colonic inflammation
Keywords: الکتریک; CAPE; Caffeic acid phenethyl ester; DHHC; Dihydrohydroxycinnamic acid phenethyl ester; DMC; Dimethoxycinnamic acid phenethyl ester; DMHC; Dimethoxydihydrocinnamic acid phenethyl ester; PPAPE; 3-phenylpropionic acid phenethyl ester; TNBS; 2,4,6-Trinitroben
Nrf2/ARE-mediated antioxidant actions of pro-electrophilic drugs
Keywords: الکتریک; ABCC; ATP-binding cassette, subfamily C; ARE; Antioxidant-response element; CA; carnosic acid; CS; Carnosol; DA; Dopamine; DMF; Dimethyl fumarate (also known as BG-12); DOX; Doxorubicin (also known as adriamycin); EP; Electrophile; GCLM; Glutamyl cysteine
Sulforaphane induces phase II detoxication enzymes in mouse skin and prevents mutagenesis induced by a mustard gas analog
Keywords: الکتریک; SM, Sulfur mustard [bis(2-chloroethyl)sulfide]; CEES, 2-(chloroethyl) ethyl sulfide; DTP, 2,6-dithiopurine; SFN, Sulforaphane; GSH, Reduced glutathione; GST, Glutathione S-transferaseSulfur mustard; Electrophile; Carcinogen; Natural product; 4-Hydroxy-non
Acrolein-induced activation of mitogen-activated protein kinase signaling is mediated by alkylation of thioredoxin reductase and thioredoxin 1
Keywords: الکتریک; Cigarette smoke; Epithelium; Electrophile; Michael addition; c-Jun N-terminal kinase; GSH
2,6-Dithiopurine, a nucleophilic scavenger, protects against mutagenesis in mouse skin treated in vivo with 2-(chloroethyl) ethyl sulfide, a mustard gas analog
Keywords: الکتریک; SM; sulfur mustard [bis(2-chloroethyl)sulfide]; CEES; 2-(chloroethyl) ethyl sulfide; DTP; 2,6-dithiopurine; IFE; interfollicular epidermis; CK6; cytokeratin 6; LD; lipoderm; IHC; immunohistochemistry; Sulfur mustard; Electrophile; Carcinogen;
The maize benzoxazinone DIMBOA reacts with glutathione and other thiols to form spirocyclic adducts
Keywords: الکتریک; CID; collision-induced dissociation; DIBOA; 2,4-dihydroxy-2H-1,4-benzoxazin-3-one; DIMBOA; 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3-one; DIM2BOA; 2,4-dihydroxy-7,8-dimethoxy-2H-1,4-benzoxazin-3-one; GSH; glutathione; 2-HMBOA; 2-hydroxy-7-methoxy-2H-1,4
Acidic sphingomyelinase induced by electrophiles promotes proinflammatory cytokine production in human bladder carcinoma ECV-304 cells
Keywords: الکتریک; Electrophile; Sphingomyelinase; Cytokine; Lipid raft;
An efficient route to diverse H-pyrazolo[5,1-a]isoquinolines via sequential multi-component/cross-coupling reactions
Keywords: الکتریک; 2-Alkynylbenzaldehyde; Cross-coupling reaction; Electrophile; Multi-component reaction; H-Pyrazolo[5,1-a]isoquinoline;
Inhibition of DNA binding activity of cAMP response element-binding protein by 1,2-naphthoquinone through chemical modification of Cys-286
Keywords: الکتریک; Electrophile; Quinone; CREB; Cysteine;
Biological targets of isothiocyanates
Keywords: الکتریک; Isothiocyanate; Electrophile; Redox signalling; Oxidative stress; Post-translational modification;
Fluoronium metathesis and rearrangements of fluorine-stabilized carbocations
Keywords: الکتریک; Enone; Trifluoromethyl cation; Electrophile; Hard and soft acid base theory (HSAB); Ion cyclotron resonance (ICR); Ion–molecule reaction
Participation of covalent modification of Keap1 in the activation of Nrf2 by tert-butylbenzoquinone, an electrophilic metabolite of butylated hydroxyanisole
Keywords: الکتریک; tert-Butylbenzoquinone; tert-Butylhydroquinone; Electrophile; Keap1; Nrf2
Proteomic profiling of acrolein adducts in human lung epithelial cells
Keywords: الکتریک; Airway epithelium; Michael addition; Electrophile; Biotin hydrazide; Redox signaling; Thioredoxin reductase
Intrinsic electrophilicity of the 4-methylsulfonyl-2-pyridone scaffold in glucokinase activators: Role of glutathione-S-transferases and in vivo quantitation of a glutathione conjugate in rats
Keywords: الکتریک; Reactive metabolite; Electrophile; Glutathione; Microsomes; Cytosol; Glutathione transferase; Pharmacokinetics
Differential reactivity of thiophene-2-carboxylic and thiophene-3-carboxylic acids: Results from DFT and Hartree–Fock theory
Keywords: الکتریک; Thiophene carboxylic acid; Reactivity; Nucleophile; Electrophile; Hartree–Fock theory; Density functional theory-conformational influence
Butyl lithium (nBuLi)-mediated carboxylation of vinylidenecyclopropanes with CO2
Keywords: الکتریک; Carboxylation; Vinylidenecyclopropane; Electrophile; nBuLi; Carbolithiation adducts; Carbon dioxide;
Increased age reduces DAF-16 and SKN-1 signaling and the hormetic response of Caenorhabditis elegans to the xenobiotic juglone
Keywords: الکتریک; Stress resistance; Acclimation; Electrophile; Oxidative stress; Transcription factor
1,2-Naphthoquinone disrupts the function of cAMP response element-binding protein through covalent modification
Keywords: الکتریک; Electrophile; Quinone; CREB; Bcl-2
Cytoprotective role of Nrf2/Keap1 system in methylmercury toxicity
Keywords: الکتریک; Methylmercury; Nrf2; Keap1; Electrophile; Cyototoxicity
Chalcone inhibits the activation of NF-κB and STAT3 in endothelial cells via endogenous electrophile
Keywords: الکتریک; Chalcone; ICAM-1; STAT3; NF-κB; Glutathione; Electrophile
Antibodies to the superantigenic site of HIV-1 gp120: Hydrolytic and binding activities of the light chain subunit
Keywords: الکتریک; Ab; antibody; AMC; 7-amino-4-methylcoumarin; BCR; B cell receptor; BSA; bovine serum albumin; CDR; complementary determining region; CHAPS; 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonic acid; EP; electrophile; FR; framework region; gp120SAg; su
Use of chiral sulfoxides in asymmetric synthesis
Keywords: الکتریک; Ac; acetyl; Acac; acetylacetone; AIBN; 2,2â²-azobisisobutyronitrile; Ar; aryl; BF3·Et2O; boron trifluoride etherate; BINAP; 2,2â²-bis(diphenylphosphanyl)-1,1â²-binaphthyl; Bn; benzyl; Boc; tert-butoxycarbonyl; Born; borneol; Bu; butyl; Cbz; benzyloxyc
Protective Roles of Nrf2 in Disease including Oral Disease
Keywords: الکتریک; Nrf2: NF-E2 related factor 2; Keap1 : Kelch-like ECH-associated proteinl; oxidative stress; electrophile; antioxidant responsive element;