
Evolution of specificity in the eukaryotic endomembrane system
Keywords: LCEA, last Common Eukaryotic Ancestor; SM, Sec1/Munc18; GAP, GTPase-activating protein; GEF, guanine exchange factor; TGN, trans-Golgi network; AP, adaptin; NPC, nuclear pore complex; MVB, multivesicular body; ENTH, epsin N-terminal homology; REP, Rab esc