Keywords: ERAD، تخریب وابسته به ER; CP, peroxidatic cysteine; CR, resolving cysteine; ER, endoplasmic reticulum; ERAD, ER-associated degradation; Ero1, ER oxidoreductin 1; GAPDH, glyceraldehyde phosphate dehydrogenase; GPx, glutathione peroxidase; MTP, microsomal triglyceride transfer prote
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Keywords: ERAD، تخریب وابسته به ER; BiP, binding immunoglobulin protein; CNX, calnexin; CRT, calreticulin; EDEM1, ER-degradation enhancing α-mannosidase-like protein 1; ER, endoplasmic reticulum; ERAD, ER-associated degradation; Ero1, endoplasmic reticulum oxidoreductin 1; GPx, glutathione
Keywords: ERAD، تخریب وابسته به ER; NAFLD, non-alcoholic fatty liver disease; T2DM, type 2 diabetes mellitus; NASH, non-alcoholic steatohepatitis; ER, endoplasmic reticulum; ERAD, ER-associated degradation; UPR, unfolded protein response; PERK, protein kinase RNA-activated (PKR)-like ER kin
Keywords: ERAD، تخریب وابسته به ER; ABC, ATP-binding cassette; BHV-1, bovine herpes virus 1; CPXV, cowpox virus; CTL, cytotoxic T lymphocyte; EBV, Epstein-Barr virus; EHV, equine herpes virus; ER, endoplasmic reticulum; ERAD, ER-associated degradation; FRET, Förster resonance energy transfe
The cytoplasmic peptide:N-glycanase (NGLY1) — Structure, expression and cellular functions
Keywords: ERAD، تخریب وابسته به ER; ER, endoplasmic reticulum; ERAD, ER-associated degradation; ENGase, endo-β-N-acetylglucosaminidase; FNGs, free N-glycans; GlcNAc, N-acetylglucosamine; MHC, major histocompatibility complex; PNGase, peptide:N-glycanase; PAW domain, a domain found in PNGase
N-Myristoylation of the Rpt2 subunit of the yeast 26S proteasome is implicated in the subcellular compartment-specific protein quality control system
Keywords: ERAD، تخریب وابسته به ER; UPS, ubiquitin proteasome system; PQC, protein quality control; ER, endoplasmic reticulum; ERAD, ER-associated degradation; CytoQC, cytoplasmic protein quality control; Ssa, stress seventy subfamily A; Ssb, stress seventy subfamily B; Sse, stress seventy
Mannosidase IA is in Quality Control Vesicles and Participates in Glycoprotein Targeting to ERAD
Keywords: ERAD، تخریب وابسته به ER; ER, endoplasmic reticulum; ERAD, ER-associated degradation; ERManI, ER α1,2 mannosidase I; EDEMs, ER-degradation enhancing mannosidase-like proteins; CNX, calnexin; ManIA, class I α1,2 mannosidase IA; QCVs, quality control vesicles; NHK, α1-antitrypsin va
BiP and Its Nucleotide Exchange Factors Grp170 and Sil1: Mechanisms of Action and Biological Functions
Keywords: ERAD، تخریب وابسته به ER; BiP; Grp170; Sil1; protein folding; nucleotide exchange factorsBAP, BiP-associated protein; ER, endoplasmic reticulum; ERAD, ER-associated degradation; ERQC, ER quality control; MSS, Marinesco-Sjögren syndrome; NBD, nucleotide binding domain; NEF, nucleot
Ubiquitin-specific protease 19 regulates the stability of the E3 ubiquitin ligase MARCH6
Keywords: ERAD، تخریب وابسته به ER; USP, ubiquitin-specific protease; DUB, deubiquitinating enzyme; ER, endoplasmic reticulum; ERAD, ER-associated degradation; E3, E3 ubiquitin ligase; NPT II, neomycin phosphotransferase II; FBS, fetal bovine serum; siRNA, small interference RNA; NEM, N-eth
Characterization of the Grp94/OS-9 Chaperone–Lectin Complex
Keywords: ERAD، تخریب وابسته به ER; ER, endoplasmic reticulum; ERAD, ER-associated degradation; TMP, terminally misfolded protein; MRH, mannose recognition homology; ITC, isothermal titration calorimetry; CTE, C-terminal extension; BME, β-mercaptoethanolchaperone; Hsp90; Grp94; ER-associate
Kinin B1 receptor homo-oligomerization is required for receptor trafficking to the cell surface
Keywords: ERAD، تخریب وابسته به ER; B1R, kinin B1 receptor; B2R, kinin B2 receptor; GPCR, G protein-coupled receptor; ER, endoplasmatic reticulum; BK, bradykinin; ERAD, ER-associated degradation; HEK293, human embryonic kidney 293; FCS, fetal calf serum; DMEM, Dulbecco's modified Eagle's me
JAB1/CSN5 inhibits the activity of Luman/CREB3 by promoting its degradation
Keywords: ERAD، تخریب وابسته به ER; ER, endoplasmic reticulum; ERAD, ER-associated degradation; HSV, herpes simplex virus; UPR, unfolded protein response; UPRE, unfolded protein responseLuman/CREB3/LZIP; JAB1/CSN5; Unfolded protein response; Protein degradation; Transcription factor
Emerging role of rhomboid family proteins in mammalian biology and disease
Keywords: ERAD، تخریب وابسته به ER; EGFR, epidermal growth factor receptor; ER, endoplasmic reticulum; ERAD, ER-associated degradation; IRHD, iRhom homology domain; iRhom, inactive rhomboid; L1, loop 1; LPS, lipopolysaccharide; RIP, regulated intramembrane proteolysis; RHBDL, rhomboid-like
Metabolic mechanisms for anoxia tolerance and freezing survival in the intertidal gastropod, Littorina littorea
Keywords: ERAD، تخریب وابسته به ER; ATF, activating transcription factor; CAT, catalase (EC 1.11.1.6); CHOP, C/EBP homologous protein; EDEM, ER degradation enhancing α-mannosidase-like protein; eIF, eukaryotic initiation factor; ERAD, ER-associated degradation; ERK, extracellular signal reg
Calreticulin signaling in health and disease
Keywords: ERAD، تخریب وابسته به ER; AML, acute myeloid leukemia; Bcl-2, B-cell lymphoma 2; C/EBPa, CCAAT enhancer-binding protein a; ER, endoplasmic reticulum; ERAD, ER-associated degradation; ERp57, ER protein of 57-kDa; InsP3R, inositol 1,4,5-triphosphate receptor; LRP, LDL receptor-relat
Involvement of the Nrf2-proteasome pathway in the endoplasmic reticulum stress response in pancreatic β-cells
Keywords: ERAD، تخریب وابسته به ER; ER, endoplasmic reticulum; UPR, unfolded protein response; ERAD, ER-associated degradation; iNrf2, NRF2 knockdown βTC-6; iSc, nonspecific control βTC-6; ARE, antioxidant-response element; GSH, glutathione; Nqo1, NAP(D)H, quinone oxidoreductase-1; Gclc, ca
Phosphatidylcholine biosynthesis and lipoprotein metabolism
Keywords: ERAD، تخریب وابسته به ER; apo, apolipoprotein; ABCA1, ATP-binding cassette transporter subfamily member A1; CD, choline-deficient; CS, choline-supplemented; CT, CTP:phosphocholine cytidylyltransferase; ER, endoplasmic reticulum; ERAD, ER-associated degradation; HDL, high density l
Two motifs with different function regulate the anterograde transport of the adiponectin receptor 1
Keywords: ERAD، تخریب وابسته به ER; AdipoR, adiponectin receptor; AMPK, AMP-activated protein kinase; AT1R, angiotensin II type 1 receptor; COPII, coat protein complex II; DSP, dithiobis[succinimidylpropionate]; ER, endoplasmic reticulum; ERAD, ER-associated degradation; FBS, fetal bovine s
Molecular and structural basis for N-glycan-dependent determination of glycoprotein fates in cells
Keywords: ERAD، تخریب وابسته به ER; ER, endoplasmic reticulum; ERAD, ER-associated degradation; GlcI, glucosidase I; GlcII, glucosidase II; UGGT, UDP-glucose:glycoprotein glucosyltransferase; CRT, calreticulin; CNX, calnexin; CRD, carbohydrate recognition domain; PDI, protein disulfide isom
Different p97/VCP complexes function in retrotranslocation step of mammalian Er-associated degradation (ERAD)
Keywords: ERAD، تخریب وابسته به ER; ER, endoplasmic reticulum; ERAD, ER-associated degradation; CF, cystic fibrosis; CFTR, cystic fibrosis transmembrane conductance regulator; AAT, α1-antitrypsin; ATZ, Z variant α1-antitrypsin; ATZ(s), secreted ATZ; ATZ(i), intracellular ATZ; Tyr, tyrosinas
Calpain digestion and HSP90-based chaperone protection modulate the level of plasma membrane F508del-CFTR
Keywords: ERAD، تخریب وابسته به ER; ER, endoplasmic reticulum; ERAD, ER-associated degradation; CFTR, cystic fibrosis transmembrane conductance regulator; CF, cystic fibrosis; C.I.2, calpain inhibitor 2F508del-CFTR; Ca2+-dependent proteolysis; Calpain; HSP90 protection
Drosophila arf72A acts as an essential regulator of endoplasmic reticulum quality control and suppresses autosomal-dominant retinopathy
Keywords: ERAD، تخریب وابسته به ER; ER, endoplasmic reticulum; ERAD, ER-associated degradation; UPR, unfolded protein response; ADRP, autosomal-dominant retinopathy; ARF, ADP ribosylation factor; ARL, Arf-like; FLP, flipase; FRT, FLP recombinase targetDrosophila arf72A small GTPase; ninaED1
Tea flavan-3-ols as modulating factors in endoplasmic reticulum function
Keywords: ERAD، تخریب وابسته به ER; ATPase, adenosine triphosphatase; BiP, immunoglobulin heavy chain binding protein; ECG, epicatechin gallate; EGCG, epigallocatechin gallate; ER, endoplasmic reticulum; ERAD, ER-associated degradation; G6P, glucose-6-phosphate; G6Pase, glucose-6-phosphatas
Evidence of endoplasmic reticular stress in the spinal motor neurons exposed to CSF from sporadic amyotrophic lateral sclerosis patients
Keywords: ERAD، تخریب وابسته به ER; ALS, Amyotrophic Lateral Sclerosis; ALS-CSF, CSF from sporadic Amyotrophic Lateral Sclerosis patients; ChAT, Choline acetyl transferase; CY3, Cyanine 3; ER, Endoplasmic reticulum; ERAD, ER-associated degradation; FBS, Fetal bovine serum; FITC, Fluorescein
N-glycoproteomics in plants: Perspectives and challenges
Keywords: ERAD، تخریب وابسته به ER; ER, endoplasmatic reticulum; cgl, complex glycan less; GlcNAc, N-acetylglucosamine; OST, oligosaccharyltransferase; ERAD, ER-associated degradation; PNGase, peptide-N-glycosidase; UPR, unfolded protein response; MALDI-TOF MS, matrix assisted laser desorpt
Solution structure and dynamics of mouse ARMET
Keywords: ERAD، تخریب وابسته به ER; ARMET, Arginine rich, mutated in early stage of tumors; DSS, 2,2-dimethyl-2-silapentane-5-sulfonic acid; bHLH, basic-helix–loop–helix; ER, endoplasmic reticulum; ERAD, ER-associated degradation; ERQC, ER quality control; HSQC, heteronuclear single quantum
Prolonged endoplasmic reticulum stress promotes mislocalization of immunoglobulins to the cytoplasm
Keywords: ERAD، تخریب وابسته به ER; ASCs, antibody secreting cells; ATF6, activating transcription factor 6; ER, endoplasmic reticulum; ERAD, ER-associated degradation; GS, glycosylation site; HCMV, human cytomegalovirus; IP, immunoprecipitation; IRE-1, inositol requiring enzyme 1; PERK, PK
UDP-GlC:glycoprotein glucosyltransferase-glucosidase II, the ying-yang of the ER quality control
Keywords: ERAD، تخریب وابسته به ER; ANS, anilinonaphtalene sulfonic acid; BiP, binding protein; CNX, calnexin; CRT, calreticulin; CZ, cruzipain; DTT, dithiothreitol; ER, endoplasmic reticulum; ERAD, ER-associated degradation; ERGIC, ER-Golgi intermediate compartment; GI, glucosidase I; GII,
TRAM1 is involved in disposal of ER membrane degradation substrates
Keywords: ERAD، تخریب وابسته به ER; ATF6, activating transcription factor 6; Cln6, ceroid-lipofuscinosis neuronal protein 6; eIF2α, alpha subunit of eukaryotic initiation factor 2; ER, endoplasmic reticulum; ERAD, ER-associated degradation; HCMV, human cytomegalovirus; MHC, major histocompa
Nucleocytoplasmic plant lectins
Keywords: ERAD، تخریب وابسته به ER; ABA, Agaricus bisporus agglutinin; Calsepa, Calystegia sepium agglutinin; EAA, Euonymus europaeus agglutinin; EGFP, enhanced green fluorescent protein; ER, endoplasmic reticulum; ERAD, ER-associated degradation; EUL, Euonymus lectin domain; Fbs, sugar-bin
Targeting of gp78 for ubiquitin-mediated proteasomal degradation by Hrd1: Cross-talk between E3s in the endoplasmic reticulum
Keywords: ERAD، تخریب وابسته به ER; RNF45; Autocrine motility factor receptor; KAI1; Atherosclerosis; Parkinson’s disease; Pael-RER, endoplasmic reticulum; ERAD, ER-associated degradation; RING, Really Interesting New Gene; Pael-R, Parkin-associated endothelin receptor-like receptor; UPR, u
Cytotoxicity and gene expression profiling of two hydroxylated polybrominated diphenyl ethers in human H295R adrenocortical carcinoma cells
Keywords: ERAD، تخریب وابسته به ER; AHR, aryl hydrocarbon receptor; ERAD, ER-associated degradation; ER, endoplasmic reticulum; PBDE, polybrominated diphenyl ether; PCB, polychlorinated biphenyl; TCDD, 2,3,7,8-tetrachlorodibenzo-p-dioxin; UPR, unfolded protein responseOH-PBDE; H295R adrenoc
New ATPase regulators—p97 goes to the PUB
Keywords: ERAD، تخریب وابسته به ER; AAA, ATPase associated with various activities; AMFR, autocrine motility factor receptor; BS1, binding site 1; dsRNA, double-stranded RNA; DUB, deubiquitylating enzyme; ERAD, ER-associated degradation; IBR, in-between ring; LUBAC, linear ubiquitin chain a
Mammalian OS-9 Is Upregulated in Response to Endoplasmic Reticulum Stress and Facilitates Ubiquitination of Misfolded Glycoproteins
Keywords: ERAD، تخریب وابسته به ER; ER, endoplasmic reticulum; ERAD, ER-associated degradation; PK, proteinase K; UPR, unfolded protein response; siRNA, small interfering RNA; NHK, null Hong Kong; TCRα, T-cell receptor α; MRH, mannose 6-phosphate receptor homology; PLP, proteolipid protein;
Stabilization of the Tertiary Structure of the Cholera Toxin A1 Subunit Inhibits Toxin Dislocation and Cellular Intoxication
Keywords: ERAD، تخریب وابسته به ER; BfA, brefeldin A; CT, cholera toxin; ER, endoplasmic reticulum; ERAD, ER-associated degradation; EDTA, ethylenediaminetetraacetic acid; β-ME, β-mercaptoethanol; GSH, glutathione; PBS, phosphate-buffered saline; PBST, PBS containing 1% Triton X-100; PDI, p
Glycobiology in the cytosol: The bitter side of a sweet world
Keywords: ERAD، تخریب وابسته به ER; Asn, asparagine; CBP, carbohydrate binding protein; Cer, ceramide; CRT, calreticulin; Dol, dolichol; ENGase, endo-β-N-acetylglucosaminidase; ER, endoplasmic reticulum; ERAD, ER-associated degradation; ERQC, ER-quality control; FITC, fluorescein isothiocia
Dual degradation mechanisms ensure disposal of NHE6 mutant protein associated with neurological disease
Keywords: ERAD، تخریب وابسته به ER; aa, amino acid; EEA1, early-endosomal antigen 1; EGF, epidermal growth factor; EGFR, EGF receptor; ESCRT, endosomal sorting complex required for transport; ER, endoplasmic reticulum; ERAD, ER-associated degradation; GFP, green fluorescent protein; NHE, Na
Rescue of mutant α-galactosidase A in the endoplasmic reticulum by 1-deoxygalactonojirimycin leads to trafficking to lysosomes
Keywords: ERAD، تخریب وابسته به ER; α-Gal A, α-galactosidase A; DGJ, 1-deoxygalactonojirimycin; ASSC, active-site-specific chaperone; ER, endoplasmic reticulum; DTT, dithiothreitol; Endo H, endoglycosidase H; ERAD, ER-associated degradation; ERT, enzyme replacement therapy; TEA, triethanola
Alterations in the glycoform of cisplatin-resistant human carcinoma cells are caused by defects in the endoplasmic reticulum-associated degradation system
Keywords: ERAD، تخریب وابسته به ER; CDDP, cis-diamineplatinum-(II) dichloride; ER, endoplasmic reticulum; ERAD, ER-associated degradation; Fuc, fucose; Gal, galactose; GlcNAc, N-acetyl-d-glucosamine; GnT, N-acetyl-d-glucosaminyltransferase; MHC, major histocompatibility complex; PA, pyridyl
Endoplasmic reticulum stress—A double edged sword for Z alpha-1 antitrypsin deficiency hepatoxicity
Keywords: ERAD، تخریب وابسته به ER; A1AT, alpha-1 antitrypsin; COPD, chronic obstructive pulmonary disease; EOR, ER overload response; ER, endoplasmic reticulum; ERAD, ER-associated degradation; Ire1, inositol requiring kinase 1; NE, neutrophil elastase; Perk, PKR-like ER kinase; siRNA, sma
Decreased ER-associated degradation of α-TCR induced by Grp78 depletion with the SubAB cytotoxin
Keywords: ERAD، تخریب وابسته به ER; CHX, cycloheximide; ER, endoplasmic reticulum; ERAD, ER-associated degradation; HUS, hemolytic-uremic syndrome; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; TCR, T-cell receptor; UFD, ubiquitin-fusion degradation; UPS, ubiquitin–prot
Ubxd1 is a novel co-factor of the human p97 ATPase
Keywords: ERAD، تخریب وابسته به ER; AAA, ATPase associated with various activities; ERAD, ER-associated degradation; NCS, newborn-calf serum; PNGase, peptide:N-glycanase; siRNA, small interfering RNA; UPR, unfolded protein response; VCP, valosin containing proteinUbiquitin; Proteasome; p97;
Dual enzymatic properties of the cytoplasmic peptide:N-glycanase in C. elegans
Keywords: ERAD، تخریب وابسته به ER; ER, endoplasmic reticulum; ERAD, ER-associated degradation; FOA, 5-fluoroorotic acid; Hepes, (N-[2-hydroxyethyl]piperazine-N′-[2-ethanesulfonic acid]); PNGase, peptide:N-glycanase; RTAΔ, ricin toxic A-chain mutant lacking a region containing catalytic res
A different pathway in the endoplasmic reticulum stress-induced expression of human HRD1 and SEL1 genes
Keywords: ERAD، تخریب وابسته به ER; EDEM, ER degradation-enhancing α-mannosidase-like protein; ER, endoplasmic reticulum; ERAD, ER-associated degradation; ERSE, endoplasmic reticulum stress response element; Tg, thapsigargin; Tm, tunicamycin; UPR, unfolded protein response; UPRE, unfolded p
Cytoplasmic peptide:N-glycanase and catabolic pathway for free N-glycans in the cytosol
Keywords: ERAD، تخریب وابسته به ER; ER, endoplasmic reticulum; ERAD, ER-associated degradation; ENGase, endo-β-N-acetylglucosaminidase; Gn1, free oligosaccharides bearing a single GlcNAc at their reducing terminus; Gn2, free oligosaccharides bearing N,N′-diacetylchitobiose at their reducing
How sugars convey information on protein conformation in the endoplasmic reticulum
Keywords: ERAD، تخریب وابسته به ER; ANS, 8-anilinonaphthalene-1-sulfonic acid; CNX, calnexin; CRT, calreticulin; EDEM, endoplasmic reticulum degradation enhancing α-mannosidase-like proteins; ER, endoplasmic reticulum; ERAD, ER-associated degradation; ERGIC, ER-Golgi intermediate compartmen
ER chaperones in mammalian development and human diseases
Keywords: ERAD، تخریب وابسته به ER; ER, endoplasmic reticulum; ERAD, ER-associated degradation; HHcy, hyperhomocysteinemia; PDI, protein disulfide isomerase; PrPsc, scrapie-associated PrP; STEC, Shiga toxigenic Escherichia coli; SubAB, AB5 subtilase cytotoxin; UPR, unfolded protein response
Ubiquitin ligase Hrd1 enhances the degradation and suppresses the toxicity of polyglutamine-expanded huntingtin
Keywords: ERAD، تخریب وابسته به ER; ER, endoplasmic reticulum; htt, huntingtin; httN, htt exon I or the N-terminal 588 amino acids with various numbers of glutamines; ERAD, ER-associated degradation; GST, glutathione S-transferase; HA, hemagglutinin; IB, immunoblotting; IP, immunoprecipitat
Low expression of cell-surface thromboxane A2 receptor β-isoform through the negative regulation of its membrane traffic by proteasomes
Keywords: ERAD، تخریب وابسته به ER; CFTR, cystic fibrosis transmembrane conductance regulator; ER, endoplasmic reticulum; ERAD, ER-associated degradation; GPCR, G protein-coupled receptor; GST, glutathione S-transferase; HRP, horseradish peroxide; PVDF, polyvinylidene difluoride; TCA, trich
Destabilization of the VCP-Ufd1-Npl4 complex is associated with decreased levels of ERAD substrates
Keywords: ERAD، تخریب وابسته به ER; ERAD, ER-associated degradation; RNAi, RNA interference; UPR, unfolded protein response; UFD, ubiquitin fusion degradation; UPS, ubiquitin–proteasome system; VCP, valosin-containing proteinER-associated degradation (ERAD); Endoplasmic reticulum; Proteasom