Keywords: ERK، سیگنال خارج سلولی kinase تنظیم شده است; AP-1, activator protein-1; DRF, dose reduction factor; ERK, extracellular signal regulated kinase; E. cava, Ecklonia cava; HO-1, heme oxygenase-1; IκBα, I kappa B kinase alpha; JNK, c-Jun N-terminal kinase; MAPK, mitogen-activated protein kinase; MKK-4, m
مقالات ISI ERK، سیگنال خارج سلولی kinase تنظیم شده است (ترجمه نشده)
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Keywords: ERK، سیگنال خارج سلولی kinase تنظیم شده است; ABTS, 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt; AC, adenylyl cyclase; cAMP, adenosine 3′,5′-cyclic monophosphate; 6-Cl-PuDP, 6-chloro purine 5′ diphosphate; DMSO, dimethyl sulfoxide; ERK, extracellular signal regulated kinase
Selective inhibition of JAK2/STAT1 signaling and iNOS expression mediates the anti-inflammatory effects of coniferyl aldehyde
Keywords: ERK، سیگنال خارج سلولی kinase تنظیم شده است; Coniferyl aldehyde; Anti-inflammatory activity; JAK2-STAT1; Nitric oxideCA, Coniferyl aldehyde; CRG, Carrageenan; ERK, Extracellular signal regulated kinase; IFN, Interferon; iNOS, Inducible nitric oxide synthase; JAK, Janus kinase; JNK, Jun amino termina
Effect of ether glycerol lipids on interleukin-1β release and experimental autoimmune encephalomyelitis
Keywords: ERK، سیگنال خارج سلولی kinase تنظیم شده است; DAMPs, danger associated molecular patterns; DMEM, dulbeccos modified eagles medium; EAE, experimental autoimmune encephalomyelitis; ERK, extracellular signal regulated kinase; LPS, lipopolysaccharide; NLRP3, NOD like receptor familypyrin domain containin
Morphine preconditioning confers cardioprotection in doxorubicin-induced failing rat hearts via ERK/GSK-3β pathway independent of PI3K/Akt
Keywords: ERK، سیگنال خارج سلولی kinase تنظیم شده است; AAR, area at risk; CPB, cardiopulmonary bypass; CF, coronary flow; DOX, doxorubicin; DMSO, dimethylsulfoxide; EGFR, epidermal growth factor receptor; ERK, extracellular signal regulated kinase; GPCR, G-protein coupled receptor; GSK, glycogen synthase kina
Ginsenoside Rg1, a potential JNK inhibitor, protects against ischemia/reperfusion-induced liver damage
Keywords: ERK، سیگنال خارج سلولی kinase تنظیم شده است; ALT, alanine amino transferase; ANOVA, a one-way analysis of variance; AST, aspartate amino transferase; DAPI, 4, 6-diamidino-2- phenylindole; DMEM, Dulbecco's modified Eagle's medium; ERK, extracellular signal regulated kinase; H&E, hematoxylin and eosin
Strain differences in stress-induced changes in central CRF1 receptor expression
Keywords: ERK، سیگنال خارج سلولی kinase تنظیم شده است; CRF, corticotropin-releasing factor; CRFR1 and CRFR2, CRF receptor 1 and 2; ERK, extracellular signal regulated kinase; FC, frontal cortex; GI, gastrointestinal; IBS, Irritable Bowel Syndrome; MAPK, mitogen activated protein kinase; PVN, paraventricular n
Hepatoprotective effect of cryptotanshinone from Salvia miltiorrhiza in d-galactosamine/lipopolysaccharide-induced fulminant hepatic failure
Keywords: ERK، سیگنال خارج سلولی kinase تنظیم شده است; ALT, alanine aminotransferase; AST, aspartate aminotransferase; ERK, extracellular signal regulated kinase; FHF, fulminant hepatic failure; GalN, d-galactosamine; GAPDH, glyceraldehydes-3-phosphate dehydrogenase; IL-1, interleukin-1; JNK, c-Jun N-terminal
Cardioprotective effects of rhamnetin in H9c2 cardiomyoblast cells under H2O2-induced apoptosis
Keywords: ERK، سیگنال خارج سلولی kinase تنظیم شده است; CAT, catalase; DMEM, Dulbecco׳s modified Eagle׳s media; DMSO, dimethylsulfoxide; ERK, extracellular signal regulated kinase; FBS, fetal bovine serum; JNK, c-Jun N-terminal protein kinase; MAPKs, mitogen-activated proteins kinases; XTT, 2,3-bis [2-methylox
The regulation of ERK and p-ERK expression by cisplatin and sorafenib in gastric cancer cells
Keywords: ERK، سیگنال خارج سلولی kinase تنظیم شده است; ERK, extracellular signal regulated kinase; EDTA, Ethylene Diamine Tetraacetic AcidPhosphorylation ERK; Apoptosis; Proliferation
17β-Estradiol inhibition of IL-6–Src and Cas and paxillin pathway suppresses human mesenchymal stem cells–mediated gastric cancer cell motility
Keywords: ERK، سیگنال خارج سلولی kinase تنظیم شده است; E2, 17β-estradiol; ERK, extracellular signal regulated kinase; HBMMSCs, human bone marrow mesenchymal stem cells; IL-6, interleukin 6; JNK, c-Jun N-terminal kinase; PI3K, phosphatidylinositol 3-kinase; p38 MAPK, p38 mitogen-activated protein kinase; Akt,
The protective effect of hispidin against hydrogen peroxide-induced apoptosis in H9c2 cardiomyoblast cells through Akt/GSK-3β and ERK1/2 signaling pathway
Keywords: ERK، سیگنال خارج سلولی kinase تنظیم شده است; CAT, catalase; DMEM, Dulbecco׳s modified Eagle׳s media; DMSO, dimethylsulfoxide; ERK, extracellular signal regulated kinase; FBS, fetal bovine serum; JNK, c-Jun N-terminal protein kinase; MAPKs, mitogen-activated proteins kinases; XTT, 2,3-bis [2-methylox
ErbB3 silencing reduces osteosarcoma cell proliferation and tumor growth in vivo
Keywords: ERK، سیگنال خارج سلولی kinase تنظیم شده است; RTK, receptor tyrosine kinase; ErbB, Erythroblastic leukemia oncogene homolog; HER1, Heregulin-1 receptor; ERK, Extracellular signal regulated kinase; PI3K, Phosphatidyl inositol 3-kinase; TMA, Tissue microarray; shRNA, short hairpin RNA; TBST, Tris buffe
Camptothecin inhibits platelet-derived growth factor-BB-induced proliferation of rat aortic vascular smooth muscle cells through inhibition of PI3K/Akt signaling pathway
Keywords: ERK، سیگنال خارج سلولی kinase تنظیم شده است; CDK, cyclin-dependent kinase; DMEM, Dulbecco's Modified Eagle's Media; DMSO, dimethyl sulfoxide; ERK, extracellular signal regulated kinase; FBS, fetal bovine serum; HEPES, N-[2-hydroxyethyl]piperazine-N-[2-ethanesulfonicacid]; PBS, phosphate buffered sal
Inhibitory effect of the antimalarial agent artesunate on collagen-induced arthritis in rats through nuclear factor kappa B and mitogen-activated protein kinase signaling pathway
Keywords: ERK، سیگنال خارج سلولی kinase تنظیم شده است; ART, artesunate; CIA, collagen-induced arthritis; ERK, extracellular signal regulated kinase; FLS, fibroblast-like synoviocyte; JNK, c-Jun N-terminal kinase; Lef, leflunomide; MAPK, mitogen-activated protein kinase; MMP, metalloproteinase; NF-κB, nuclear
Hsp90 inhibition by NVP-AUY922 and NVP-BEP800 decreases migration and invasion of irradiated normoxic and hypoxic tumor cell lines
Keywords: ERK، سیگنال خارج سلولی kinase تنظیم شده است; Actin remodeling; Cell matrix; Cell adhesion; Hypoxia; Radiation; Stress fibersCGM, complete growth medium; FAK, focal adhesion kinase; Erk, extracellular signal regulated kinase; FBS, fetal bovine serum; GA, geldanamycin; IR, ionizing radiation; Hsp, hea
MicroRNA-21 suppresses PTEN and hSulf-1 expression and promotes hepatocellular carcinoma progression through AKT/ERK pathways
Keywords: ERK، سیگنال خارج سلولی kinase تنظیم شده است; HCC, hepatocellular carcinoma; EMT, epithelial–mesenchymal transition; AKT, PI3 K-protein kinase B; ERK, extracellular signal regulated kinase; hSulf-1, human sulfatase-1; qRT-PCR, quantitative reverse transcription-polymerase chain reaction; HSPG, hepara
Interaction between mineralocorticoid receptor and epidermal growth factor receptor signaling
Keywords: ERK، سیگنال خارج سلولی kinase تنظیم شده است; MR, mineralocorticoid receptor; GR, glucocorticoid receptor; ERK, extracellular signal regulated kinase; EGFR, epidermal growth factor receptor; MAPK, mitogen-activated protein kinase; EGF, epidermal growth factor; ki-Ras-2a, Kirsten rat sarcoma viral onc
Trimethyltin-induced neurotoxicity: Gene expression pathway analysis, q-RT-PCR and immunoblotting reveal early effects associated with hippocampal damage and gliosis
Keywords: ERK، سیگنال خارج سلولی kinase تنظیم شده است; BSA, bovine serum albumin; CCL2, chemokine (C–C motif) ligand 2; CDK, cyclin-dependent kinase; ELISA, enzyme-linked immunosorbent assay; ERK, extracellular signal regulated kinase; ESTs, expressed sequence tags; GR, glucocorticoid receptor; GC-RMA, gene c
Danshen–Gegen decoction protects against hypoxia/reoxygenation-induced apoptosis by inhibiting mitochondrial permeability transition via the redox-sensitive ERK/Nrf2 and PKCɛ/mKATP pathways in H9c2 cardiomyocytes
Keywords: ERK، سیگنال خارج سلولی kinase تنظیم شده است; ABT, 1-aminotriazole; Akt, alpha-serine threonine kinase; BAD, Bcl-2 associated death promoter; CYP, cytochrome P-450; ERK, extracellular signal regulated kinase; DCFDA, 2′-7′-dichlorofluorescein diacetate; DG, Danshen–Gegen; DMTU, dimethylthiouracil; GCL
Type I interferons directly down-regulate BCL-6 in primary and transformed germinal center B cells: Differential regulation in B cell lines derived from endemic or sporadic Burkitt’s lymphoma
Keywords: ERK، سیگنال خارج سلولی kinase تنظیم شده است; AID, activation-induced cytidine deaminase; BCR, B cell receptor; BL, Burkitt’s lymphoma; CD40L, CD40 ligand; CHX, cycloheximide; eBL, endemic BL; EBV, Epstein–Barr virus; ERK, extracellular signal regulated kinase; GC, germinal center; IFN, interferon; I
Dipeptidyl peptidase 4 as a therapeutic target in ischemia/reperfusion injury
Keywords: ERK، سیگنال خارج سلولی kinase تنظیم شده است; BM, bone marrow; BNP, brain natriuretic peptide; EC, endothelial cell; ERK, extracellular signal regulated kinase; GLP-1, glucagon-like peptide-1; GSK3β, glycogen synthase kinase-β; GLUT, glucose transporter; HIF-1, hypoxia-inducible factor-1; IRI, ischem
Syk mediates BCR- and CD40-signaling integration during B cell activation
Keywords: ERK، سیگنال خارج سلولی kinase تنظیم شده است; Ab, antibody; Ag, antigen; BLNK, B cell linker; BM, bone marrow; Btk, Bruton tyrosine kinase; ERK, extracellular signal regulated kinase; IP3, inositol 1,4,5-trisphosphate; JNK, c-Jun NH2-terminal kinase; PKC, protein kinase C; MAPK, mitogen-activated pro
Nicotine ameliorates impairment of working memory in methamphetamine-treated rats
Keywords: ERK، سیگنال خارج سلولی kinase تنظیم شده است; ERK, extracellular signal regulated kinase; METH, methamphetamine; nAChRs, nicotinic acetylcholine receptors; PPI, prepulse inhibitionNicotine; Methamphetamine; Working memory; Psychosis
The mitochondrial permeability transition pore and cyclophilin D in cardioprotection
Keywords: ERK، سیگنال خارج سلولی kinase تنظیم شده است; ANT, adenine nucleotide translocase; CsA, cyclosporine A; CyP, cyclophilin; Drp1, dynamin-related protein 1; Δψm, mitochondrial membrane potential; ERK, extracellular signal regulated kinase; GSK, glycogen synthase kinase; IMM, inner mitochondrial membran
Ethylacetate fraction from Korean seaside starfish, Asterias amurensis, has an inhibitory effect on MMP-9 activity and expression and on migration behavior of TNF-α induced human aortic smooth muscle cells
Keywords: ERK، سیگنال خارج سلولی kinase تنظیم شده است; MMP, matrix metalloproteinase; ERK, extracellular signal regulated kinase; NF-κB, nuclear factor kappa B; HASMC, human aortic smooth muscle cell; TNF-α, tumor necrosis factor-α; VSMC, vascular smooth muscle cell; EFA, ethylacetate fraction from Asterias a
Wounding systemically activates a mitogen-activated protein kinase in forage and turf grasses
Keywords: ERK، سیگنال خارج سلولی kinase تنظیم شده است; ABA, abscisic acid; ERK, extracellular signal regulated kinase; GTP, guanosine triphosphate; JA, jasmonic aci0d; Lt, Lolium temulentum; MAPK, mitogen-activated protein kinase; MJ, methyl jasmonate; NADPH, nicotinamide adenine dinucleotide phosphate; PAGE,
Vitamin C-deficiency stimulates osteoclastogenesis with an increase in RANK expression
Keywords: ERK، سیگنال خارج سلولی kinase تنظیم شده است; ALP, alkaline phosphatase; AP-1, activator protein-1; Asc, ascorbic acid; BMMs, bone marrow-derived monocyte/macrophage precursor cells; DHA, dehydroascorbic acid; ERK, extracellular signal regulated kinase; FCS, fetal calf serum; Hyp, hydroxyproline; JNK
The evolution of alternative splicing exons in vascular endothelial growth factor A
Keywords: ERK، سیگنال خارج سلولی kinase تنظیم شده است; AS, Alternative Splicing; ERK, Extracellular signal Regulated Kinase; ESE, Exonic Splicing Enhancer; FIGF, C-fos induced growth factor; GAPDH, Glyceraldehyde 3-phosphate dehydrogenase; HSPG, Heparan Sulfate Proteoglycan; NRP, Neuropilin; PDGF, Platelet De
Platelet-derived growth factor-induced signaling pathways interconnect to regulate the temporal pattern of Erk1/2 phosphorylation
Keywords: ERK، سیگنال خارج سلولی kinase تنظیم شده است; Erk, extracellular signal regulated kinase; Src, Rous sarcoma virus oncogene product; PI3K, phosphoinositide 3-kinase; PLCγ, phospholipase Cγ; PKC, protein kinases C; PAE, porcine aortic endothelial; PDGF, platelet-derived growth factor; PDGFR, PDGF recep
Monoamine oxidases (MAO) in the pathogenesis of heart failure and ischemia/reperfusion injury
Keywords: ERK، سیگنال خارج سلولی kinase تنظیم شده است; 5-HT, serotonin; ASK-1, apoptosis signal-regulating kinase 1; AT, angiotensin; CHF, congestive heart failure; ERK, extracellular signal regulated kinase; FA, fatty acid; I/R, ischemia/reperfusion; JNK, c-Jun N-terminal kinase; LV, left ventricle; MAPK, mi
A farnesylated G-protein suppresses Akt phosphorylation in INS 832/13 cells and normal rat islets: Regulation by pertussis toxin and PGE2
Keywords: ERK، سیگنال خارج سلولی kinase تنظیم شده است; Erk, extracellular signal regulated kinase; FoxO1, Forkhead box protein O1; FTI, farnesyl transferase inhibitor; FTase, farnesyl transferase; GTP, guanosine triphosphate; IGF-1, insulin-like growth factor-1; MEK, mitogen activated extracellular kinase; MP
Abnormal elevated PTEN expression in the mouse antrum of a model of GIST KitK641E/K641E
Keywords: ERK، سیگنال خارج سلولی kinase تنظیم شده است; bpV(phen), potassium bisperoxo(1,10-phenanthroline)oxovanadate (V); ERK, Extracellular signal Regulated Kinase; FBS, Fetal bovine serum; FGF, Fibroblast growth factor; GAPDH, Glyceraldehyde 3-phosphate dehydrogenase; GIST, Gastrointestinal stromal tumor;
Pyruvate kinase type M2: A key regulator of the metabolic budget system in tumor cells
Keywords: ERK، سیگنال خارج سلولی kinase تنظیم شده است; CREB, cAMP response element binding protein; ERK, extracellular signal regulated kinase; HCV, hepatitis C virus; HPV, human papillomavirus; IL, interleukin; JAK, Janus kinase; MAGUK, membrane-associated guanylate kinase; MAPK, mitogen-activated protein ki
Association study of BDNF and DRD3 genes in schizophrenia diagnosis using matched case–control and family based study designs
Keywords: ERK، سیگنال خارج سلولی kinase تنظیم شده است; SCZ, schizophrenia; DRD3, dopamine D3 receptor gene; BDNF, brain-derived neurotrophic factor gene; SNP, single-nucleotide polymorphism; GPCR, G-protein coupled receptor; ERK, extracellular signal regulated kinase; cAMP, cyclic Adenosine Mono-Phosphate; FB
The membrane estrogen receptor GPR30 mediates cadmium-induced proliferation of breast cancer cells
Keywords: ERK، سیگنال خارج سلولی kinase تنظیم شده است; Cd, cadmium; E2, 17-β estradiol; ER, estrogen receptor; GPR30, G-protein coupled receptor 30; cAMP, cyclic adenosine monophosphate; mek, mitogen-activated protein kinase kinase; erk, extracellular signal regulated kinase; rsk, ribosomal S6 kinase; elk, E-
Inhibition of angiogenesis by quercetin in tamoxifen-resistant breast cancer cells
Keywords: ERK، سیگنال خارج سلولی kinase تنظیم شده است; AP-1, activator protein-1; CAM, chick chorioallantoic membrane; DMEM, Dulbecco’s modified Eagle’s medium; HIF-1α, hypoxia inducible factor-1α; ERK, extracellular signal regulated kinase; FBS, fetal bovine serum; JNK, c-Jun N-terminal kinase; MAP kinase, m
Growth Differentiation Factor 5 Regulates Cardiac Repair After Myocardial Infarction
Keywords: ERK، سیگنال خارج سلولی kinase تنظیم شده است; collagen gene expression; growth differentiation factor 5; mitogen-activated protein kinase; myocardial infarctionAW, anterior wall; ERK, extracellular signal regulated kinase; Gdf5, growth differentiation factor 5; ID1, inhibitor of differentiation 1; LA
The B[a]P-increased intercellular communication via translocation of connexin-43 into gap junctions reduces apoptosis
Keywords: ERK، سیگنال خارج سلولی kinase تنظیم شده است; AhR, aryl hydrocarbon receptor; B[a]P, benzo[a]pyrene; CR, cholesterol rich; Cx43, connexin-43; DAPI, 4′,6′-diamidino-2-phenylindole ER, endoplasmic reticulum; ERK, extracellular signal regulated kinase; FITC, fluorescein isothiocyanate; GJ, gap junction;
Targeted therapy of thyroid cancer
Keywords: ERK، سیگنال خارج سلولی kinase تنظیم شده است; Bcr-ABL, A fusion between the Breakpoint cluster region and the Abl genes; DTC, differentiated thyroid carcinoma; ERK, extracellular signal regulated kinase; FGFR, fibroblast growth factor receptor; FTC, follicular thyroid carcinoma; HDAC, histone deacety
Defining the pathway to insulin-like growth factor system targeting in cancer
Keywords: ERK، سیگنال خارج سلولی kinase تنظیم شده است; EGCG, epigallocatechin gallate; EGFR, epidermal growth factor receptor; Erk, extracellular signal regulated kinase; GPCR, G-protein coupled receptor; HNSCC, head and neck squamous cell carcinoma; IGF-1, insulin-like growth factor-1; IGFBP, IGF-binding pro
Temporal and Spatial Changes in Collateral Formation and Function During Chronic Myocardial Ischemia
Keywords: ERK، سیگنال خارج سلولی kinase تنظیم شده است; AAR, area at risk (ischemic myocardial territory); AIF, apoptosis inducing factor; eNOS, endothelial nitric oxide synthase; ERK, extracellular signal regulated kinase; ET-1, endothelin-1; HSP, heat shock protein; ILM, isotope-labeled microspheres; LCx, le
NBCn1 and NHE1 expression and activity in ΔNErbB2 receptor-expressing MCF-7 breast cancer cells: Contributions to pHi regulation and chemotherapy resistance
Keywords: ERK، سیگنال خارج سلولی kinase تنظیم شده است; ΔNErbB2, N-terminally truncated ErbB2 receptor; EIPA, 5-(N-ethyl-N isopropyl)-amiloride; ERK, extracellular signal regulated kinase; LMP, lysosomal membrane permeabilization; NHE1, Na+/H+-exchanger isoform 1; NBCn1, electroneutral Na+,HCO3—cotransporter 1
CCL23 up-regulates expression of KDR/Flk-1 and potentiates VEGF-induced proliferation and migration of human endothelial cells
Keywords: ERK، سیگنال خارج سلولی kinase تنظیم شده است; VEGF, vascular endothelial growth factor; KDR/Flk-1, kinase insert domain-containing receptor/fms-like tyrosine kinase 1; ERK, extracellular signal regulated kinase; MAPK, mitogen activated protein kinase; PMA, phorbol 12-myristate 13-acetateCCL23; KDR/Fl
Effect of the DEF motif on phosphorylation of peptide substrates by ERK
Keywords: ERK، سیگنال خارج سلولی kinase تنظیم شده است; ERK, extracellular signal regulated kinase; MAP, mitogen-activated protein; JNK, c-jun N-terminal kinase; His6, hexahistidine; FAM, fluorescein; AOO, 8-amino dioxaoctanoic acid; PDB, protein data bankMAP kinase; Docking motifs; FXFP motif; Peptide substra
c-myb stimulates cell growth by regulation of insulin-like growth factor (IGF) and IGF-binding protein-3 in K562 leukemia cells
Keywords: ERK، سیگنال خارج سلولی kinase تنظیم شده است; DN-myb, dominant negative myb; IGF, insulin-like growth factor; IGFBP, insulin-like growth factor binding protein; IGF-IR, insulin-like growth factor-I receptor; Erk, extracellular signal regulated kinase; MAPK, mitogen-activated protein kinase; PI3 kinas
NM23H2 inhibits EGF- and Ras-induced proliferation of NIH3T3 cells by blocking the ERK pathway
Keywords: ERK، سیگنال خارج سلولی kinase تنظیم شده است; EGF, epidermal growth factor; ERK, extracellular signal regulated kinase; NDPK, nucleoside diphosphate kinase; NM23, non-metastatic clone 23Proliferation; NM23; NM23H2; Metastasis; ERK; Ras; Signal transduction; The Ras-ERK pathway
JNK/AP-1 pathway is involved in tumor necrosis factor-α induced expression of vascular endothelial growth factor in MCF7 cells
Keywords: ERK، سیگنال خارج سلولی kinase تنظیم شده است; AP-1; JNK; MCF7; VEGFAP-1, activator protein-1; ChIP, chromatin immunoprecipitation; ERK, extracellular signal regulated kinase; JNK, c-Jun N-terminal kinase; MAPK, mitogen-activated protein kinase; NF-κB, nuclear factor-κB; TNF-α, tumor necrosis factor-α
Cellular mechanisms underlying affective resiliency: The role of glucocorticoid receptor- and mitochondrially-mediated plasticity
Keywords: ERK، سیگنال خارج سلولی kinase تنظیم شده است; Bcl-2, B-cell CLL/lymphoma 2; BAG-1, Bcl-2-associated athanogene; BPD, bipolar disorder; BDNF, brain-derived neurotrophic factor; ERK, extracellular signal regulated kinase; FKBP5, 51 kDa FK506-binding protein; GR, glucocorticoid receptor; Hsp, heat shock
Bromocriptine induces parapoptosis as the main type of cell death responsible for experimental pituitary tumor shrinkage
Keywords: ERK، سیگنال خارج سلولی kinase تنظیم شده است; Bc, Bromocriptine; ERK, Extracellular Signal Regulated Kinase; JNK, Stress Related c-jun NH2-terminal kinase; MAPK, Mitogen Activated Protein Kinase; PARP, poly (ADP-ribose) polymerase; PCD, Programmed Cell Death; P-ERK1/2, phosphorylated ERK1/2; PKCδ, Pr