
Sphingosine-1-phosphate/S1PR2-mediated signaling triggers Smad1/5/8 phosphorylation and thereby induces Runx2 expression in osteoblasts
Keywords: ALP, alkaline phosphatase; BMP, bone morphogenetic protein; ERK, extracellular signal regulated protein kinase; GSK-3β, glycogen synthase kinase 3β; I-Smad, inhibitory Smad; PI3K, phosphatidylinositol 3-kinase; ROCK, Rho kinase; ROI, region of interest; R