Discovery of 3(S)-thiomethyl pyrrolidine ERK inhibitors for oncology
Keywords: مهار کننده ارک; ERK inhibitor; ATP competitive; MAP kinases; Kinase selectivity; Oncology;
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Targeting ERK, an Achilles' Heel of the MAPK pathway, in cancer therapy
Keywords: مهار کننده ارک; Mitogen-activated protein kinases; Extracellular signal-regulated kinase; ERK inhibitor; ERK kinase; Cancer therapy; Drug resistance;
Phenformin Enhances the Efficacy of ERK Inhibition in NF1-Mutant Melanoma
Keywords: مهار کننده ارک; AMPK; AMP-activated kinase; BRAFi; BRAF inhibitor; ERK; extracellular signal-regulated kinase; ERKi; ERK inhibitor; PGC1α; peroxisome proliferator-activated receptor gamma, coactivator 1-α; MEK; MAPK/ERK kinase; MEKi; MEK inhibitor; mTOR; mechanistic ta
Oxidant species are involved in T/B-mediated ERK1/2 phosphorylation that activates p53-p21 axis to promote KSHV lytic cycle in PEL cells
Keywords: مهار کننده ارک; KSHV; Kaposi's sarcoma-associated herpesvirus; B; butyrate; ERK; Extracellular Signal-regulated Kinase; MAPKs; Mitogen-Activated Protein Kinases; PD98059; ERK inhibitor; PEL; Primary Effusion Lymphoma; PKCs; protein kinases C; Q; quercetin; ROS; reactive
Isoniazid prevents Nrf2 translocation by inhibiting ERK1 phosphorylation and induces oxidative stress and apoptosis
Keywords: مهار کننده ارک; Isoniazid; Oxidative stress; Differential expression; Phosphorylation; ERK inhibitor
Pulsed electromagnetic field enhances brain-derived neurotrophic factor expression through L-type voltage-gated calcium channel- and Erk-dependent signaling pathways in neonatal rat dorsal root ganglion neurons
Keywords: مهار کننده ارک; Electromagnetic field; Calcium; Dorsal root ganglion neurons; Brain-derived neurotrophic factor; Erk inhibitor
Attenuated expression of the tight junction proteins is involved in clopidogrel-induced gastric injury through p38 MAPK activation
Keywords: مهار کننده ارک; DAPI; 4â²,6-diamidino-2-phenylindole; DMSO; dimethyl sulfoxide; ERK; extracellular signal-regulated kinase; FITC; fluorescein isothiocyanate; GES-1; immortalized human gastric epithelial cells line; GI; gastrointestinal; HBSS; Hank's Balanced Salt Soluti
Arsenic-induced alteration in intracellular calcium homeostasis induces head kidney macrophage apoptosis involving the activation of calpain-2 and ERK in Clarias batrachus
Keywords: مهار کننده ارک; MS222; Methanesulfonate salt; RPMI-1640; Roswell Park Memorial Institute culture medium-1640; FBS; Fetal bovine serum; ROS; Reactive oxygen species; MAPK; Mitogen activated protein kinase; ERK; Extracellular signal-regulated kinase; JNK; c-Jun NH2-termina
Identification of a selective ERK inhibitor and structural determination of the inhibitor-ERK2 complex
Keywords: مهار کننده ارک; ERK; MAPK; ERK inhibitor; Selective kinase inhibitor; Transforming growth factor β; AP-1;
Pharmacological inhibitors of extracellular signal-regulated protein kinases attenuate the apoptotic action of cisplatin in human myeloid leukemia cells via glutathione-independent reduction in intracellular drug accumulation
Keywords: مهار کننده ارک; Ac-DEVD-pNA; N-acetyl-Asp-Glu-Val-Asp-p-nitroaniline; BHA; butylated hydroxyanisole; BSO; dl-buthionine-(S,R)-sulfoximine; CDDP; cisplatin, cis-platinum (II)-diammine dichloride; DAPI; 4,6-diamino-2-phenylindole; ERK; extracellular signal-regulated kinase