
Design synthesis and structure–activity relationship of 5-substituted (tetrahydronaphthalen-2yl)methyl with N-phenyl-N-(piperidin-2-yl)propionamide derivatives as opioid ligands
Keywords: GPCR, G protein-coupled receptor; MOR, Mu opioid receptor; DOR, delta opioid receptor; Boc, tert-butyloxycarbonyl; NaOtBu, sodium tert-butoxide; Et3N, triethylamine; HCl, hydrochloric acid; BH3-SMe2, borane dimethylsulfide; DHP, dihydropyran; PPTS, pyridi