دانلود مقالات ISI درباره F, Bioavailability + ترجمه فارسی

برآورد تغییرات در کسری جذب شده به عنوان یک پارادایم برای اطلاع رسانی در توسعه فرمول در پیشرفت اولیه داروهای بالینی

Estimating the variability in fraction absorbed as a paradigm for informing formulation development in early clinical drug development

Keywords: F, Bioavailability; fa, fraction absorbed; fg, fraction passing the gut wall; fh, fraction escaping hepatic metabolism; GI, gastrointestinal; NLME, nonlinear mixed effect modelling; IR, immediate release; PR, prolonged release; ICH, international conferen

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

مدلسازی فیزیولوژیکی مبتنی بر فارماکوکینتیک از نحوه قرارگیری و درگیریهای متابولیسم داروی آتورواستاتین و متابولیتهای آن

Physiologically based pharmacokinetic modeling of disposition and drug–drug interactions for atorvastatin and its metabolites

Keywords: AUC, area under the concentration–time curve; CL, clearance; Cmax, maximum concentration; CYP, cytochrome P450; DDI, drug–drug interaction; F, bioavailability; HMG–CoA, 3-hydroxy-3-methylglutaryl–coenzyme A; Jmax, maximum rate of transporter-mediated effl

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2015 سفارش ترجمه

Systemic in vitro and in vivo evaluation for determining the feasibility of making an amorphous solid dispersion of a B-Raf (rapidly accelerated fibrosarcoma) inhibitor

Keywords: AUC, area under the concentration-timer profile; CL, clearance; Cmax, maximum concentration; Cp, isobaric heat capacity; DSC, differential scanning calorimetry; F, bioavailability; HPLC, High Performance Liquid Chromatography; Tg, glass transition tempera

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Pharmacokinetics of conjugated metabolites in rat plasma after oral administration of tectoridin

Keywords: Te-7G-4′S, tectorigenin-7-O-glucuronide-4′-sulfate; Te-7G, tectorigenin-7-O-glucuronide; Te-7S, tectorigenin-7-O-sulfate; Te-4′S, tectorigenin-4′-O-sulfate; AUC, area under the curve; CL, clearance; ESI, electrospray ionization; F, bioavailability; Cmax,

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Hepatitis C RNA-dependent RNA polymerase inhibitors: A review of structure–activity and resistance relationships; different scaffolds and mutations

Keywords: ADA, adenosine deaminase; DAAs, direct-acting antivirals; F, bioavailability; HCC, hepatocellular carcinoma; HCV, Hepatitis C virus; INF, interferon alpha; NIs, nucleosides inhibitors; NNIs, non-nucleosides inhibitors; PEG-IFN, pegylated interferon; PNP,

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

High-throughput analysis of standardized pharmacokinetic studies in the rat using sample pooling and UPLC–MS/MS

Keywords: ACN, acetonitrile; AUC, area under the curve; CL, clearance; DMA, dimethylamine; F, bioavailability; LOQ, limit of quantification; PEG400, polyethylene glycol 400; PK, pharmacokinetic; rt, retention time; T1/2, half life; UPLC–MS/MS, ultra performance liq

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Absorption and tissue distribution of a novel carboxymethyldextran after oral administration

Keywords: i.p., Intraperitoneal injection; i.v., Intravenous injection; F, Bioavailability; AUMC, Area under the first moment curve; RGTA, for ReGeneraTing Agent; PK, Pharmacokinetics; Vd, Volume of distribution; AUCCL, Area under curve; CL, Clearance; Cmax, Maximu

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Discovery and biological evaluation of potent, selective, orally bioavailable, pyrazine-based blockers of the Nav1.8 sodium channel with efficacy in a model of neuropathic pain

Keywords: TTx, tetrodotoxin; TTx-r, tetrodotoxin-resistant; VGSC, voltage gated sodium channels; DRG, dorsal root ganglia; ip, intraperitoneal; iv, intravenous; po, per os; F, bioavailability; T1/2, half-life; Clp, plasma clearance; CEREP, cell-surface receptors, i

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2010 سفارش ترجمه

Optimising in vivo pharmacology studies—Practical PKPD considerations

Keywords: C, Total plasma concentration; Cu, Unbound plasma or tissue concentration; fu, Unbound fraction in plasma; F, Bioavailability; ip, Intraperitoneal; iv, Intravenous; MAO, Monoamine oxidase; NEFA, Non-esterified free fatty acids; NiAc, Nicotinic acid; PD, P

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2010 سفارش ترجمه