Single chain TNF derivatives with individually mutated receptor binding sites reveal differential stoichiometry of ligand receptor complex formation for TNFR1 and TNFR2
Keywords: BS3, bis-(sulfosuccinimidyl)-suberate; CRD, cysteine rich domain; DISC, death inducing signaling complex; FADD, Fas-associating protein with death domain; FasL, Fas ligand; HEK, human embryonic kidney; KD, dissociation constant; mAb, monoclonal antibody;