Induction and repair of DNA double-strand breaks using constant-field gel electrophoresis and apoptosis as predictive markers for sensitivity of cancer cells to cisplatin
Keywords: Cisplatin; Drug-resistance; Induction of DSB; Residual breaks; Cell cycle regulation; ApoptosisCIS, cisplatin; DSBs, double-strand breaks; Fas-L, Fas ligand; SRB, sulphorhodamine-B; CFGE, constant-field gel electrophoresis; DDR, DNA-damage response