Disruption of IGF-1R signaling increases TRAIL-induced apoptosis: A new potential therapy for the treatment of melanoma
Keywords: FasL، Fas لیگاند; AP-1, activator protein-1; DR4, death receptor-4; DR5, death receptor-5; EMSA, electrophoretic mobility shift assay; ERK, extracellular signal-regulated kinase; FACS, fluorescence-activated cell sorter; FasL, Fas ligand; IκB, inhibitor of NF-κB; IGF-1, in