Keywords: NAFLD; nonalcoholic fatty liver disease; NASH; nonalcoholic steatohepatitis; FC; free cholesterol; VLDL; very low density lipoprotein; LDL; low density lipoprotein; mTOR; mechanistic target of rapamycin signaling; AMPK; AMP-activated protein kinase; TG; t
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Keywords: Bile acids; FGF15; Hypothalamus; FGF receptors; AGRP; Melanocortins;
Keywords: ASBT; apical sodium-dependent bile acid transporter; ASDs; amorphous solid dispersions; BACS; bile acid-CoA synthase; BAT; bile acid-amino acid transferase; BCS; biopharmaceutics classification system; BSH; bile salt hydrolase; C4; 7α-hydroxy-4-cholesten
Keywords: 2210010C04Rik; RIKEN cDNA 2210010C04 gene; 5330417C22Rik; RIKEN cDNA 5330417C22 gene; A1AT; alpha1-antitrypsin; Ago1; argonaute RISC catalytic component 1; Amy2a5; amylase 2a5; Amy2b; amylase, alpha 2B; AP1/JUN; jun proto-oncogene; Bmp; bone morphogenetic
Keywords: Liver regeneration; Bile acid; FXR; TGR5; FGF15;
Keywords: Bile acids; Transintestinal cholesterol excretion; TICE; FGF15; Cholestasis; Reverse cholesterol transport; Alpha-muricholate (PubChem CID: 53477700); Beta-muricholate (PubChem CID: 5283853); Cholate(PubChem CID: 221493); Cholesterol (PubChem CID: 5997);
Aryl hydrocarbon receptor (AhR) mediated short-term effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on bile acid homeostasis in mice
Keywords: Aryl hydrocarbon receptor; TCDD; Bile acids; Biliary excretion; Taurodeoxycholic acid; Cyp8b1; 1°BAs; Primary bile acids; 2°BAs; Secondary bile acids; 6-OH; 6-hydroxylated (6-OH); 12-OH; 12α-hydroxylated; Abc; ATP-binding cassette; AhR; Aryl hydrocarbo
Mouse species-specific control of hepatocarcinogenesis and metabolism by FGF19/FGF15
Keywords: FGF19; FGF15; Carcinoma, hepatocellular; Bile acids and salts; Glucose; Body weight; Cyp7a1; Obesity; Diet; Receptors, cytoplasmic and nuclear; Metabolic diseases;
GATA4 Is Sufficient to Establish Jejunal Versus Ileal Identity in the Small Intestine
Keywords: Transcriptional Regulation; Jejunal Identity; Enterohepatic Signaling; Fgf15; FXR; bio-ChIP-seq; biotin-mediated chromatin immunoprecipitation with high-throughput sequencing; bp; base pair; cDNA; complementary DNA; cKI; conditional knock-in; cKO; conditi
Metabolic fibroblast growth factors (FGFs): Mediators of energy homeostasis
Keywords: DIO; diet induced obesity; FGF; fibroblast growth factor; FGFR; fibroblast growth factor receptor; UCP1; uncoupling protein 1; KO; knockout; CNS; central nervous system; SNA; sympathetic nerve activity; ICV; intracerebroventricular; ChREBP; carbohydrate r
Sensitization to autoimmune hepatitis in group VIA calcium-independent phospholipase A2-null mice led to duodenal villous atrophy with apoptosis, goblet cell hyperplasia and leaked bile acids
Keywords: AB-PAS; alcian blue-periodic acid schiff; AIH; autoimmune hepatitis; ALT; alanine aminotransferase; AP; alkaline phosphatase; AST; aspartate aminotransferase; Bcl-2; B-cell lymphoma 2; CA; cholic acid; CCL; chemokine ligand; CCR; chemokine receptor; CDCA;
Intestine-Specific Deletion of SIRT1 in Mice Impairs DCoH2-HNF-1α-FXR Signaling and Alters Systemic Bile Acid Homeostasis
Keywords: Ileal Bile Acid Absorption; Bile Acid Synthesis; Liver Damage; Cholestasis; CA; cholic acid; DCoH2; dimerization cofactor of hepatocyte nuclear factor 1α 2; FGF15; fibroblast growth factor 15; FXR; farnesoid X receptor; HA; hemagglutinin; HNF-1α; hepato
Vitamin D Receptor Activation Down-regulates the Small Heterodimer Partner and Increases CYP7A1 to Lower Cholesterol
Keywords: Liver; Bile Acid; Farnesoid X Receptor; Transcriptional Regulation; Asbt; rodent apical sodium dependent bile acid transporter; CDCA; chenodeoxycholic acid; ChIP; chromatin immunoprecipitation; Cyp7a1/CYP7A1; rodent/human cholesterol 7α-hydroxylase; 1,25
The heteromeric organic solute transporter, OSTα-OSTβ/SLC51: A transporter for steroid-derived molecules
Keywords: OSTα-OSTβ; Bile acids; FGF15; FXR; Slc51aâ/â mice; Steroids;
Research ArticleMouse organic solute transporter alpha deficiency alters FGF15 expression and bile acid metabolism
Keywords: BA; bile acid(s); Asbt; apical sodium-dependent bile acid transporter; Ost; organic solute transporter; FXR; farnesoid X receptor; FGF15; fibroblast growth factor 15; Cyp7a1; cholesterol 7α-hydroxylase; FGFR4; fibroblast growth factor receptor 4; CA; cho
PXR Prevents Cholesterol Gallstone Disease by Regulating Biosynthesis and Transport of Bile Salts
Keywords: Fgf15; PCN; Nuclear Receptor; Gene Regulation; Transgenic MiceAbc, ATP binding cassette; Asbt, apical sodium-dependent bile acid transporter; Bsep, bile salt export pump; CAR, constitutive androstane receptor; CGD, cholesterol gallstone disease; CSI, chol
Sonic hedgehog is involved in formation of the ventral optic cup by limiting Bmp4 expression to the dorsal domain
Keywords: Sonic hedgehog; Smoothened; Conditional knock-out; Optic cup; Proliferation; Cell death; BMP4; Pax2/6; Vax1/2; Fgf15
A New Mechanism for Bile Acid Diarrhea: Defective Feedback Inhibition of Bile Acid Biosynthesis
Keywords: ASBT; apical sodium-dependent bile acid transporter; BA; bile acid; BAM; bile acid malabsorption; C4; 7α-hydroxy-4-cholesten-3-one; CYP7A1; cholesterol 7α hydroxylase; ELISA; enzyme-linked immunosorbent assay; FGFR4; fibroblast growth receptor 4; FGF15;
Expression of Fgf15 is regulated by both activator and repressor forms of Gli2 in vitro
Keywords: Fgf15; Gli2; Sonic hedgehog; Enhancer/promoter; Activator/repressor
Analysis of Fibroblast growth factor 15 cis-elements reveals two conserved enhancers which are closely related to cardiac outflow tract development
Keywords: Fgf15; FGF19; Fgf8; Enhancer; Pharyngeal epithelium; Rhombomere1; Cardiac neural crest; Outflow tract; Congenital heart defects