Keywords: NAFLD; nonalcoholic fatty liver disease; NASH; nonalcoholic steatohepatitis; FC; free cholesterol; VLDL; very low density lipoprotein; LDL; low density lipoprotein; mTOR; mechanistic target of rapamycin signaling; AMPK; AMP-activated protein kinase; TG; t
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Keywords: ATP; Adenosine 5c-triphosphate; ALT; Alanine aminotransferase; aa; Amino acid; ASK1; Apoptosis signal- regulating kinase 1; AST; Aspartate aminotransferase; BASH; Both alcoholic and non-alcoholic liver disease; CCR2/CCR5; C-C chemokine receptor types 2 an
Keywords: Cholic Acid; Chenodeoxycholic Acid; 7α-Hydroxy-4-Cholesten-3-One; GPBAR1 (G-Protein-Coupled Bile Acid Receptor 1); BA; bile acid; BAM; bile acid malabsorption; C4; 7α-hydroxy-4-cholesten-3-one; CDCA; chenodeoxycholic acid; DCA; deoxycholic acid; FGF19
Keywords: Bile acids; FGF19; Type 2 diabetes; Obesity; Mixed meal test; BA; bile acid; CA; cholic acid; DCA; deoxycholic acid; CDCA; chenodexocholic acid;
Keywords: NASH; nonalcoholic steatohepatitis; NAFD; nonalcoholic fatty liver disease; FXR; farnesoid X receptor; FGF19; fibroblast growth factor; DMSO; dimethyl sulfoxide; CYP; cytochrome P450; Liver; Flow; FXR; NASH; Transcriptomics; Obeticholic;
Keywords: IF; intestinal failure; PN; parenteral nutrition; IFALD; intestinal failure associated liver disease; IL-6; interleukin-6; TNF-α; tumor necrosis factor-α; FGF19; fibroblast growth factor 19; FXR; farnesoid nuclear receptor X; NAFLD; nonalcoholic fatty l
Alteration in the serum concentrations of FGF19, FGFR4 and βKlotho in patients with thyroid cancer
Keywords: Thyroid cancer; FGF19; FGFR4; βKlotho; Serum concentration;
Molecular elements in FGF19 and FGF21 defining KLB/FGFR activity and specificity
Keywords: FGF19; FGF21; KLB; FGFR isoforms; FGF antagonism; Structure-activity-relationship; Alanine-scan;
Dysregulation of serum bile acids and FGF19 in alcoholic hepatitis
Keywords: FGF19; Bile acids; Microbiome;
FGF19 and FGF21 serum concentrations in human obesity and type 2 diabetes behave differently after diet- or surgically-induced weight loss
Keywords: Weight loss; Bariatric surgery; Diet; FGF19; FGF21; Obesity;
Farnesoid X Receptor Agonist Treatment Alters Bile Acid Metabolism but Exacerbates Liver Damage in a Piglet Model of Short-Bowel Syndrome
Keywords: Short-Bowel Syndrome; Liver Disease; Intestinal Failure-Associated Liver Disease; Obeticholic Acid; Bile Acids; Farnesoid X Receptor; FXR; farnesoid X receptor; OCA; obeticholic acid; CDCA; chenodeoxycholic acid; FGF19; fibroblast growth factor-19; HCA;
Mouse species-specific control of hepatocarcinogenesis and metabolism by FGF19/FGF15
Keywords: FGF19; FGF15; Carcinoma, hepatocellular; Bile acids and salts; Glucose; Body weight; Cyp7a1; Obesity; Diet; Receptors, cytoplasmic and nuclear; Metabolic diseases;
Metabolic fibroblast growth factors (FGFs): Mediators of energy homeostasis
Keywords: DIO; diet induced obesity; FGF; fibroblast growth factor; FGFR; fibroblast growth factor receptor; UCP1; uncoupling protein 1; KO; knockout; CNS; central nervous system; SNA; sympathetic nerve activity; ICV; intracerebroventricular; ChREBP; carbohydrate r
Sustained Brown Fat Stimulation and Insulin Sensitization by a Humanized Bispecific Antibody Agonist for Fibroblast Growth Factor Receptor 1/βKlotho Complex
Keywords: Brown adipose tissue; Therapeutic antibody; Thermogenesis; Adipose tissue browning; Humanized antibody; Adiponectin; FGF21; FGF19; FGFR1; betaKlotho; UCP1; Bispecific antibody; Insulin resistance; Obesity; Type 2 diabetes; Hepatosteatosis; NASH
Duodenal diverted sleeve gastrectomy with ileal interposition does not cause biliary salt malabsorption
Keywords: Ileal interposition; T2DM; FGF19; C4; Malabsorption;
SREBP-2 negatively regulates FXR-dependent transcription of FGF19 in human intestinal cells
Keywords: ChIP; chromatin immunoprecipitation; DR-1; direct repeat separated by 1 nucleotide; EMSA; electrophoretic mobility shift assay; ER-8; everted repeat separated by 8 nucleotides; FXR; farnesoid X receptor; FGF19; fibroblast growth factor 19; GST; glutathion
Central action of FGF19 reduces hypothalamic AGRP/NPY neuron activity and improves glucose metabolism
Keywords: FGF19; Diabetes; Obesity; AGRP/NPY neurons
Research ArticleAltered FXR signalling is associated with bile acid dysmetabolism in short bowel syndrome-associated liver disease
Keywords: SBS; short bowel syndrome; SBS-ALD; short bowel syndrome-associated liver disease; PN; parenteral nutrition; SBR; small bowel resection; BA; bile acid; FXR; farnesoid X receptor; SHP; small heterodimer partner; FGF19; fibroblast growth factor 19; CYP7A1;
Farnesoid X Receptor Protects Hepatocytes From Injury by Repressing miR-199a-3p, Which Increases Levels of LKB1
Keywords: Nuclear Receptor; Noncoding RNA; Mitochondrial Protection; Fibrotic Liver Injury; AA; arachidonic acid; AMPK; AMP-activated protein kinase; ASO; antisense oligonucleotide; CAB39; calcium binding protein 39; CDCA; chenodeoxycholic acid; DCFH-DA; 2â²,7â²-
Hormone-like fibroblast growth factors and metabolic regulation
Keywords: FGF19; FGF21; FGF23; Klotho; βKlotho; Metabolic regulation
Bile acid signaling after an oral glucose tolerance test
Keywords: Postprandial response; Oral glucose tolerance test; Bile acids; FGF19; 7α-Hydroxy-4-cholesten-3-one
The FGFR D3 Domain Determines Receptor Selectivity For Fibroblast Growth Factor 21
Keywords: FGF, fibroblast growth factor; FGFR, fibroblast growth factor receptor; pERK, phospho-ERK; MSD, Meso Scale Discoveryfibroblast growth factor; FGF19; FGF21; FGFR1c; FGFR4
Chenodeoxycholate in Females With Irritable Bowel Syndrome-Constipation: A Pharmacodynamic and Pharmacogenetic Analysis
Keywords: Bile Acid; 7αC4; FGF19; FGFR4; AC; ascending; ANCOVA; analysis of covariance; BMI; body mass index; CDC; (sodium) chenodeoxycholate; CF6; colonic filling at 6 hours; FGF19; fibroblast growth factor 19; FGFR4; fibroblast growth factor receptor 4; GC; geom
A New Mechanism for Bile Acid Diarrhea: Defective Feedback Inhibition of Bile Acid Biosynthesis
Keywords: ASBT; apical sodium-dependent bile acid transporter; BA; bile acid; BAM; bile acid malabsorption; C4; 7α-hydroxy-4-cholesten-3-one; CYP7A1; cholesterol 7α hydroxylase; ELISA; enzyme-linked immunosorbent assay; FGFR4; fibroblast growth receptor 4; FGF15;
Subtype-specific expression of Fgf19 during horizontal cell development of the chicken retina
Keywords: Fgf19; Retina; Horizontal cells; Chicken; Development; Prox1; Lim1; Islet1
Fibroblast growth factor receptor 4 regulates proliferation, anti-apoptosis and alpha-fetoprotein secretion during hepatocellular carcinoma progression and represents a potential target for therapeutic intervention
Keywords: AFP; alpha-fetoprotein; ANOVA; analysis of variance; ELISA; enzyme-linked immunosorbent assay; FGF19; fibroblast growth factor 19; FGFR; fibroblast growth factor receptor; FRS2α; FGFR substrate protein-2α; GAPDH; glyceraldehyde 3-phosphate dehydrogenase
Fgf19 is required for zebrafish lens and retina development
Keywords: Fgf; Fgf19; Zebrafish; Lens; Retina; Cell survival; Axial patterning; Axon guidance
Analysis of Fibroblast growth factor 15 cis-elements reveals two conserved enhancers which are closely related to cardiac outflow tract development
Keywords: Fgf15; FGF19; Fgf8; Enhancer; Pharyngeal epithelium; Rhombomere1; Cardiac neural crest; Outflow tract; Congenital heart defects
Expression of Fgf19 in the developing chick eye
Keywords: Development and regeneration; Visual system; Fgf19; Chick embryo; Retinal development; Retinal neuroblasts; Neurogenesis; Gradients of differentiation;
Fgf19 regulated by Hh signaling is required for zebrafish forebrain development
Keywords: Fgf; Fgf19; Fgf3; Fgf8; Hh; Zebrafish; Regionalization; Cell proliferation; Neuronal differentiation; Forebrain;