Keywords: Fhit; Wwox; Chromosome fragile site; Genome caretaker; DNA double-strand breaks;
مقالات ISI (ترجمه نشده)
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Keywords: CCA; cholangiocarcinoma; OS; overall survival; miRNA; microRNA; TSG; tumor suppressor genes; ICC; intrahepatic cholangiocarcinoma; OV; Opisthorchis viverrini; CpG; scytosine guanine dinucleotides; DNMT; DNA methyltransferases; EZH2; zeste homolog 2; RASSF
Keywords: ccRCC; clear cell renal cell carcinoma; FHIT; fragile histidine triad; HWE; Hardy-Weinberg equilibrium; LOH; loss of heterozygosity; MGB; minor groove binder; OR; odds ratio; PFS; progression-free survival; PTPRD; protein tyrosine phosphatase receptor t
Keywords: Ap3A; diadenosine triphosphate; ERK; extracellular signal regulated kinase; FHIT; fragile histidine triad protein; GSSG; oxidized glutathione; GSH; reduced glutathione; LC3; microtubule associated protein 1 light chain 3; NAC; N-acetyl-cysteine; NADPH; ni
Mutations of candidate tumor suppressor genes at chromosome 3p in intrahepatic cholangiocarcinoma
Keywords: VHL; von Hippel-Lindau tumor suppressor; PPARG; peroxisome proliferator-activated receptor gamma; PLCD1; phospholipase C delta 1; RASSF1; Ras association domain family member 1; BAP1; BRCA1-associated protein 1; HYAC1; hyaluronoglucosaminidase 1; ACY1; am
Phosphorothioate analogs of P1,P3-di(nucleosid-5â²-yl) triphosphates: Synthesis, assignment of the absolute configuration at P-atoms and P-stereodependent recognition by Fhit hydrolase
Keywords: AP3A; Polyphosphate; Oxathiaphospholane methodology; Absolute configuration; Fhit; P-chirality;
Relationship between expression of P27, Fragile Histidine Triad (FHT), phosphatase and tensin homolog deleted on chromosome ten (PTEN), P73, and prognosis in esophageal squamous cell carcinoma
Keywords: Esophageal squamous carcinoma; FHIT; PTEN; P27; P73
Combined TP53 mutation/3p loss correlates with decreased radiosensitivity and increased matrix-metalloproteinase activity in head and neck carcinoma
Keywords: Head and neck cancer; TP53 mutation; 3p Deletion; FHIT; Matrix metalloproteinases; “double-hit”; “single-hit”; Double-stranded DNA breaks; RNA interference; Radiosensitivity;
Reduced FHIT expression is associated with tumor progression in sporadic colon adenocarcinoma
Keywords: FHIT; Colon adenocarcinoma; LOH; mRNA; Immunohistochemistry
Signaling crosstalk of FHIT, CHK2 and p38 in etoposide induced growth inhibition in MCF-7 cells
Keywords: FHIT; fragile histidin Triad; MAPK; mitogen-activated protein kinase; CHK2; checkpoint kinase 2; ERK; extracellular-regulated kinase; siRNA; Small interfering RNA; FHIT; P38; CHK2; Etoposide; DNA damage;
Activation of Gαq subunits up-regulates the expression of the tumor suppressor Fhit
Keywords: GRPR; gastrin-releasing peptide receptor; BK2R; bradykinin type 2 receptor; β2AR; β2 adrenergic receptor; MT1R; melatonin type 1 receptor; CHX; cycloheximide; eIF; eukaryotic initiation factor; 4EBP1; eIF4E binding protein 1; RGS; regulator of G protein
Enduring Response to Everolimus as Third-Line Therapy in a Patient With Advanced Renal Cell Carcinoma, Including Small-Bowel Metastases: Loss of FHIT but Normal VHL Gene Status
Keywords: Comorbidities; Cytogenetics; FHIT; Kidney; Oncology; Safety; Sequential treatment;
Inactivation of Both FHIT and p53 Cooperate in Deregulating Proliferation-Related Pathways in Lung Cancer
Keywords: Cell cycle; Tumor suppressor genes; FHIT; p53
Identification of early target genes of aflatoxin B1 in human hepatocytes, inter-individual variability and comparison with other genotoxic compounds
Keywords: AFB1; Transcriptomics; Genotoxic compounds; Biomarker; FHIT; Human hepatocytes; HepaRG cells; Non-genotoxic compounds
High-resolution Whole-Genome Analysis of Skull Base Chordomas Implicates FHIT Loss in Chordoma Pathogenesis
Keywords: FHIT; fragile histidine triad; SNP; single-nucleotide polymorphism;
Prognostic Value of Chromosomal Imbalances in Squamous Cell Carcinoma and Adenocarcinoma of the Lung
Keywords: AC; adenocarcinoma; A-CDK2; active cyclin-dependent kinase 2; ANCA; average number of copy alterations; APC; Adenomatous Polyposis coli; ARG; Abelson-related oncogene; CGH; comparative genomic hybridization; CI; confidence interval; DNA; deoxyribonucleic
Hit proteins, mitochondria and cancer
Keywords: HIT domain; Hint proteins; Fhit; Aprataxin; Apoptosis; Mitochondria
Mutational and promoter hypermethylation status of FHIT gene in breast cancer patients of Kashmir
Keywords: FHIT; Breast cancer; Kashmir; Mutation; Hypermethylation
Immunohistochemical FHIT expression still exists in early lesions of basal cell carcinoma
Keywords: Immunohistochemical; FHIT; Expression; BCC; Carcinoma
Study of FHIT and WWOX expression in mucoepidermoid carcinoma and adenoid cystic carcinoma of salivary gland
Keywords: Salivary gland cancer; Mucoepidermoid carcinoma; Adenoid cystic carcinoma; FHIT; WWOX; Basal-like phenotype
Prevention of urinary bladder cancer in the FHIT knock-out mouse with Rofecoxib, a Cox-2 inhibitor
Keywords: Urinary bladder cancer; Rofecoxib; Cox-2; FHIT; Knock-out mouse
Aberration of the enzymatic activity of Fhit tumor suppressor protein enhances cancer cell death upon photodynamic therapy similarly to that driven by wild-type Fhit
Keywords: Fhit; Protoporphyrin IX; Complex detection; Apoptosis; Photodynamic therapy;
Modulation of genomic and postgenomic alterations in noncancer diseases and critical periods of life
Keywords: AP-1; activator protein-1; BAL; bronchoalveolar lavage; 5,6-BF; 5,6-benzoflavone; B(a)P; benzo(a)pyrene; COPD; chronic obstructive pulmonary diseases; CS; cigarette smoke; Cx43; connexin 43; DMBA; 7,12-dimethylbenz(a)anthracene; ÉdA; 1,N-ethenodeoxyadeni
Correlation of intracellular diadenosine triphosphate (Ap3A) with apoptosis in Fhit-positive HEK293 cells
Keywords: FHIT; Diadenosines; Tumor suppression; Apoptosis
Increased sensitivity to bleomycin in upper aerodigestive tract mucosa of head and neck squamous cell carcinoma patients
Keywords: Bleomycin; Mutagen sensitivity; HNSCC; Chromosome aberration; FHIT
The JNK inhibitor SP600129 enhances apoptosis of HCC cells induced by the tumor suppressor WWOX
Keywords: HCC; hepatocellular carcinoma; LOH; loss of heterozygosity; WWOX; WW-domain containing oxidoreductase gene; FHIT; fragile histidine triad gene; FBS; fetal bovine serum; WWOX; Hepatocellular carcinoma; JNK; Apoptosis;
Abnormal fragile histidine triad (Fhit) expression in invasive cervical adenocarcinoma: association with tumor aggressiveness
Keywords: FHIT; Tumor markers; Uterine cervix, adenocarcinoma
Induction of apoptosis by tumor suppressor FHIT via death receptor signaling pathway in human lung cancer cells
Keywords: FHIT; Tumor suppressor; Apoptosis; Death receptor; Caspase; Lung cancer
Tumor suppressor Fhit protein interacts with protoporphyrin IX in vitro and enhances the response of HeLa cells to photodynamic therapy
Keywords: Fhit; Protoporphyrin IX; Complex formation; Diadenosine triphosphate; Photodynamic therapy; HeLa cells
Effect of inducible FHIT and p53 expression in the Calu-1 lung cancer cell line
Keywords: FHIT; p53; p21; Lung cancer; Inducible expression system
Frequent FHIT gene loss of heterozygosity in human papillomavirus-infected non-smoking female lung cancer in Taiwan
Keywords: FHIT; LOH; HPV-associated lung cancer
Aberrant methylation of Fragile Histidine Triad gene is associated with poor prognosis in early stage esophageal squamous cell carcinoma
Keywords: Esophageal cancer; FHIT; Methylation; Prognosis; Recurrence; Smoking
Roles of FHIT and WWOX fragile genes in cancer
Keywords: FHIT; WWOX; Fragile genes; Tumor suppressors; Breast cancer
Fhit protein inhibits cell growth by attenuating the signaling mediated by nuclear factor-κB in colon cancer cell lines
Keywords: FHIT; Nuclear factor-κB; Colon cancer; Growth inhibition
Loss of p27 expression and microsatellite instability in sporadic colorectal cancer
Keywords: p27; Fhit; MSI; Colorectal cancer; hMlh1; hMsh2;
Molecular genetic alterations of FHIT and p53 genes in benign and malignant thyroid gland lesions
Keywords: FHIT; p53; Apoptosis; Benign thyroid gland lesions; Thyroid cancer
A mouse model of the fragile gene FHIT: From carcinogenesis to gene therapy and cancer prevention
Keywords: Mouse model; FHIT; Fragile site; Tumor spectrum; Carcinogenesis; Gene delivery;
Promoter hypermethylation profile of RASSF1A, FHIT, and sFRP1 in intracranial primitive neuroectodermal tumors
Keywords: FHIT; Hypermethylation; Medulloblastoma; RASSF1A; sFRP1; Supratentorial primitive neuroectodermal tumor;
Perspectives on the molecular epidemiology of aerodigestive tract cancers
Keywords: ADH; alcohol dehydrogenase; APC; adenomatous polyposis coli; 5-AZA-CdR; 5-azacytidine2â²deoxycytidine; BPDE; benzo(a)pyrene diol epoxide; BRCA1; breast cancer1; CCND1; cyclin D1; CDH1; cadherin 1; CDH13; cadherin 13; CDK4; cyclin-dependent kinase 4; CDKN