دانلود مقالات ISI درباره Flipr + ترجمه فارسی

مشخصات فارماکولوژیک آنالوگهای مگدرون و مواد روانگردان جدید مرتبط

Pharmacological profile of mephedrone analogs and related new psychoactive substances

Keywords: Mephedrone; New psychoactive substances; Monoamine; Receptors; Transporters; 2,3-DMMC; 2,3-dimethylmethcathinone; 2,4-DMMC; 2,4-dimethylmethcathinone; 3,4-DMMC; 3,4-dimethylmethcathinone; 3-MMC; 3-methylmethcathinone; 4-MA; 4-methylamphetamine; 4-MMC; 4-m

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2018 سفارش ترجمه

سنتز شیمیایی و ارزیابی بیولوژیکی اسیدهای چرب اشباع نشده اسیدهای چرب اشباع نشده

Chemical synthesis and biological evaluation of ω-hydroxy polyunsaturated fatty acids

Keywords: ARA; arachidonic acid; COX; cyclooxygenase; CYP 450; cytochrome P450; DHA; docosahexaenoic acid; EPA; eicosapentaenoic acid; FLIPR; fluorescent imaging plate reader; 22-HDoHE; 22-hydroxydocosahexaenoic acid; 20-HEPE; 20-hydroxyeicosapentaenoic acid; 20-HE

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

تأثیر تترامتیلدینیزولفوتترامین بر نوسانات کلسیم همزمان در مراحل تکامل تکاملی کشت های عصبی هیپوکامپ

Influence of tetramethylenedisulfotetramine on synchronous calcium oscillations at distinct developmental stages of hippocampal neuronal cultures

Keywords: ARA-C; cytosine β-d-arabinofuranoside; [Ca2+]i; intracellular Ca2+ concentration; AUC; area under curve; CI; confidence intervals; DIV; days in vitro; FLIPR; Fluorescent Imaging Plate Reader; GFAP; glial fibrillary acidic protein; GABA; γ-aminobutyric a

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

مقاله اصلی در دسترس بودن داده های غربالگری کانال یون بالا و پیامدهای آن برای ارزیابی ایمنی قلب

Original articleVariability in high-throughput ion-channel screening data and consequences for cardiac safety assessment

Keywords: AP(D); Action Potential (Duration); AZ; AstraZeneca; FLIPR; FLuorometric Imaging Plate Reader; GSK; GlaxoSmithKline; HTS; High Throughput Screening [assays]; IC50; Concentration for 50% Inhibition; ICaL; L-type calcium current; IKr; rapid delayed rectifie

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Monoamine receptor interaction profiles of 4-thio-substituted phenethylamines (2C-T drugs)

Keywords: Phenethylamines; Psychedelics; Receptor; Affinity; New psychoactive substances; 4-bromo-2,5-dimethoxyphenethylamine; 2C-B; 2,5-dimethoxy-4-methylthiophenethylamine; 2C-T-1; 2,5-dimethoxy-4-(β-methallyl)thiophenethylamine; 2C-T-3; 2,5-dimethoxy-4-isopropy

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2018 سفارش ترجمه

An SAR study of hydroxy-trifluoromethylpyrazolines as inhibitors of Orai1-mediated store operated Ca2+ entry in MDA-MB-231 breast cancer cells using a convenient Fluorescence Imaging Plate Reader assay

Keywords: FLIPR; Fluorescence Imaging Plate Reader; STIM1; stromal interaction molecule 1; ER; endoplasmic reticulum; TNBC; triple negative breast cancer; SAR; structure activity relationship; LHS; left hand side; RHS; right hand side; THF; tetrahydrofuran; i-PrOH;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2018 سفارش ترجمه

MLN3126, an antagonist of the chemokine receptor CCR9, ameliorates inflammation in a T cell mediated mouse colitis model

Keywords: CCL25; C-C motif chemokine ligand 25; CCR9; C-C chemokine receptor 9; CD; Crohn's disease; CHO; Chinese hamster ovary; FLIPR; fluorometric imaging plate reader; IBD; inflammatory bowel disease; LP; lamina propria; SCID; C.B-17/Icr-scid mice; TNF; tumor ne

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2018 سفارش ترجمه

A potent neuromedin U receptor 2-selective alkylated peptide

Keywords: Ac; acetyl; Arg(Me); Nω-methylarginine; Cha; 3-cyclohexylalanine; CNS; central nervous system; DIO; diet-induced obese; DMF; N,N-dimethylformamide; FLIPR; fluorometric imaging plate reader; Fmoc; 9-fluorenylmethoxycarbonyl; GIT; gastrointestinal tract; Î

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2017 سفارش ترجمه

Reprint of Pharmacological and molecular characterization of the positive allosteric modulators of metabotropic glutamate receptor 2

Keywords: Metabotropic glutamate receptor; mGlu2; mGlu3; mGluR; Negative allosteric modulators; Positive allosteric modulators; LY354740; LY487379; ECL; extracellular loop; FLIPR; Fluorometric Imaging Plate Reader; GPCR; G-protein coupled receptor; mGluR; metabotro

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2017 سفارش ترجمه

Evaluation of known and novel inhibitors of Orai1-mediated store operated Ca2+ entry in MDA-MB-231 breast cancer cells using a Fluorescence Imaging Plate Reader assay

Keywords: Calcium signalling; Store-operated calcium entry (SOCE); Pharmacological inhibitors; Pharmacophore modelling; Orai1; Breast cancer; AFU; arbitrary fluorescence units; CPA; cyclopiazonic acid; [Ca2+]CYT; cytosolic free Ca2+; ER; endoplasmic reticulum; FLIP

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2017 سفارش ترجمه

Assessment of Free Drug Concentration in Cyclodextrin Formulations Is Essential to Determine Drug Potency in Functional In Vitro Assays

Keywords: cyclodextrins; drug delivery; cell culture; solubility; CD; cyclodextrin; CDtot; total concentration of substrate; CHO; Chinese hamster ovary cells; EC50; half maximal effective concentration; FLIPR; fluorometric imaging plate readers; fu.cal; calculated

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Differential Regulation of CXCL8 Production by Different G Protein Subunits with Synergistic Stimulation by Gi- and Gq-Regulated Pathways

Keywords: ELR; Glu-Leu-Arg; GPCRs; G protein-coupled receptors; NFκB; nuclear factor κB; STAT3; signal transducer and activator of transcription 3; MEM; minimum essential media; FLIPR; fluorometric imaging plate reader; G protein-coupled receptors; CXCL8; interle

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2016 سفارش ترجمه

The orexin 1 receptor modulates kappa opioid receptor function via a JNK-dependent mechanism

Keywords: GPCR; G protein-coupled receptor; OX1R; orexin 1 receptor; KOR; kappa opioid receptor; JNK; c-Jun N-terminal kinase; cAMP; cyclic adenosine monophosphate; VTA; ventral tegmental area; CHO; Chinese hamster ovary; FLIPR; fluorescence in situ plate reader; P

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

In vitro pharmacological characterization of vorapaxar, a novel platelet thrombin receptor antagonist

Keywords: PAR1; protease activated receptor 1; huCASMC; human coronary artery smooth muscle cells; HCl; hydrochloric acid; MgCl2; magnesium chloride; CaCl2; calcium chloride; NaCl; sodium choride; KCl; potassium chloride; K2HPO4; dipotassium phosphate; EGTA; ethyle

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Exploration of the molecular architecture of the orthosteric binding site in the α4β2 nicotinic acetylcholine receptor with analogs of 3-(dimethylamino)butyl dimethylcarbamate (DMABC) and 1-(pyridin-3-yl)-1,4-diazepane

Keywords: nACh receptor agonists; Structure-activity studies; Ls-AChBP; Ac-AChBP; Lobeline; DMABC analogs; Ac; Aplysia californica; ACh; acetylcholine; AChBP; acetylcholine binding protein; CNS; central nervous system; CDI; 1,1′-carbonyldiimidazole; Ct; Capitel

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2015 سفارش ترجمه

AFQ056/mavoglurant, a novel clinically effective mGluR5 antagonist: Identification, SAR and pharmacological characterization

Keywords: [Ca2+]i; intracellular Ca2+ concentration; CDZ; chlordiazepoxide; 95% CI; 95-percent confidence interval (as obtained with best-curve fitting); FLIPR; Fluorescence Imaging Plate Reader™ (assay); GABAB; gamma-amino butyric acid receptor, subtype B; l-Glu

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2014 سفارش ترجمه

Evaluation of an in silico cardiac safety assay: Using ion channel screening data to predict QT interval changes in the rabbit ventricular wedge

Keywords: AP (D); Action Potential (Duration); ECG; electrocardiogram; ECVAM; European Centre for the Validation of Alternative Methods; FLIPR; FLuorescence Imaging Plate Reader; GSK; GlaxoSmithKline; hERG; human-Ether-a-go-go Related Gene; IC50; Concentration for

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Identification, biological characterization and pharmacophoric analysis of a new potent and selective NK1 receptor antagonist clinical candidate

Keywords: NK; neurokinin; SP; substance P; GPCR; G protein-coupled receptor; CNS; central nervous system; SAD; social anxiety disorders; CINV; chemotherapy-induced nausea and vomiting; PoC; prove of concept; SAR; structure-activity relationship; CDI; carbonyldiim

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

NMDA-induced ERK signalling is mediated by NR2B subunit in rat cortical neurons and switches from positive to negative depending on stage of development

Keywords: NR2B receptor; Extracellular signal-regulated kinase (ERK); FLIPR; Rat cortical neurons; NMDA receptor antagonistCP-101,606, 1-[(1S,2S)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]-4-phenyl-4-piperidinol; ERK, extracellular signal-regulated protein kinase

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Competitive antagonism of insect GABA receptors by iminopyridazine derivatives of GABA

Keywords: AC; American cockroach; CC; common cutworm; FLIPR; fluorometric imaging plate reader; FMP; FLIPR membrane potential; GABA; γ-aminobutyric acid; SBP; small brown planthopper; Iminopyridazine; Competitive antagonism; GABA receptor; GABA-gated chloride chan

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Mimicking nature's noses: From receptor deorphaning to olfactory biosensing

Keywords: BAW; bulk acoustic wave; BRET; bioluminescence resonance energy transfer; cVA; 11-cis-vaccenyl acetate; cAMP; cyclic adenosine monophosphate; cGMP; cyclic guanosine monophosphate; CNG; cyclic nucleotide gated; EAG; electroantennagram; EOG; electroolfactog

دانلود رایگان متن کامل مقاله ISI 27 صفحه سال انتشار : 2011 سفارش ترجمه

Interaction of ibogaine with human α3β4-nicotinic acetylcholine receptors in different conformational states

Keywords: AChR; nicotinic acetylcholine receptor; NCA; noncompetitive antagonist; PCP; phencyclidine; [3H]TCP; [piperidyl-3,4-3H(N)]-(N-(1-(2 thienyl)cyclohexyl)-3,4-piperidine); Ibogaine (or 12-methoxyibogamine); 7-ethyl-6,2,7,8,9,10,12,13-octahydro-2-methoxy-6,9-

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2010 سفارش ترجمه

Inducible expression and pharmacological characterization of the mouse metabotropic glutamate 5b receptor

Keywords: Metabotropic glutamate receptor; mGlu5; G protein-coupled receptor; Calcium; FLIPR; Allosteric antagonist; HEK-293 cells; Ecdysone; Ponasterone

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2008 سفارش ترجمه

Development and validation of a platelet calcium flux assay using a fluorescent imaging plate reader

Keywords: Platelets; Calcium; GPCR; FLIPR; Thromboxane receptor; Purinergic receptors; Ion channel

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2006 سفارش ترجمه

2-[4-(3,4-Dimethylphenyl)piperazin-1-ylmethyl]-1H benzoimidazole (A-381393), a selective dopamine D4 receptor antagonist

Keywords: Dopamine; D4 antagonist; Penile erection; A-381393; 2-[4-(3,4-dimethylphenlyl)piperazin-1-ylmethyl]-1H benzoimidazole; DMEM; Dulbecco's modified Eagle's medium; DPBS; Dulbecco's phosphate buffered saline with D-glucose and sodium pyruvate; FLIPR; fluorome

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2005 سفارش ترجمه

Establishment of robust functional assays for the characterization of neuropeptide Y (NPY) receptors: identification of 3-(5-benzoyl-thiazol-2-ylamino)-benzonitrile as selective NPY type 5 receptor antagonist

Keywords: Neuropeptide Y receptor; Ligand binding; Cyclic AMP inhibition; GTPγS binding; Fluorimetric imaging plate reader; Antagonism; NPY; Neuropeptide Y; PYY; Peptide YY; PP; Pancreatic Polypeptide; Y; NPY receptor; FLIPR; fluorimetric image plate reader; GPCR;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2005 سفارش ترجمه

Discovery of an MIT-like atracotoxin family: Spider venom peptides that share sequence homology but not pharmacological properties with AVIT family proteins

Keywords: ACh; acetylcholine; ACTX; atracotoxin; BCA; bicinchoninic acid; Bv8; 8 kDa protein from the skin secretions of toads (Bombina variegata); CHO; Chinese hamster ovary; DDH; disulfide-directed β-hairpin; EST; expressed sequence tag; FLIPR; fluorometric ima

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2005 سفارش ترجمه

HIV chemokine receptor inhibitors as novel anti-HIV drugs

Keywords: AIDS; acquired immune deficiency syndrome; AOP; aminooxypentane; CI; clinical isolate; DC; dendritic cell; DC-SIGN; dendritic cell-specific ICAM-3-grabbing nonintegrin; FDA; Food and Drug Administration; FLIPR; fluorometric imaging plate reader; GCP; gran

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2005 سفارش ترجمه

Cell-based and biochemical screening approaches for the discovery of novel HIV-1 inhibitors

Keywords: beta-Gal; beta-galactosidase; CAT; chloramphenicol acetyltransferase; CHO; Chinese Hamster Ovary; CV-N; cyanovirin-N; dsDNA; double-stranded DNA; Ec; ecdysone; EIA; enzyme immunoassay; ELISA; enzyme-linked immunosorbent assay; Env; envelope; FLIPR; Fluoro

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2005 سفارش ترجمه