Keywords: αSMA; alpha-smooth muscle actin; ABCG2; ATP-binding cassette sub-family G member 2; ACE; angiotensin-converting enzyme; ASK1; apoptosis signal-regulating kinase 1; BF; bright field; CD90; cluster of differentiation 90; CF; cardiac fibroblast; COPD; chron
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Keywords: AGP; α-1 acid glycoprotein; ANA; anti-nuclear antigen; AUC; area under the curve; β2MG; Beta-2-microglobulin; BILAG; British Isles Lupus Assessment Group score; C3; complement factor 3; C4; complement factor 4; CKD; chronic kidney disease patients; CrCl
Keywords: ACPP; activated cell-penetrating peptide; AFM; atomic force microscopy; AN; angiopeptin; ANP; NP modified with ACPP peptide; APE-1; apurinic endonuclease-1; AU; gold; AUC; area under the curve; AUNP; gold nanoparticles; AUNS; gold nanoshells; BAT; brain a
TRAF3IP2 mediates TWEAK/TWEAKR-induced pro-fibrotic responses in cultured cardiac fibroblasts and the heart
Keywords: Fn14; CIKS; Act1; adverse cardiac remodeling; migration; Act1; NF-kappa B Activator 1; ANP; atrial natriuretic peptide; AP-1; activator protein-1; CCL; C-C Motif Chemokine Ligand; CD; Cluster of Differentiation; CF; cardiac fibroblasts; CIKS; Connection t
The deposition of anti-DNA IgG contributes to the development of cutaneous lupus erythematosus
Keywords: CCL; chemokine (C C motif) ligand; CLE; cutaneous lupus erythematosus; ELISA; enzyme-linked immunosorbent assay; Fn14; fibroblast growth factor inducible 14; JAK; janus-activated kinase; IP-10; interferon gamma-induced protein 10; MCP-1; monocyte chemotac
TWEAK/Fn14 promotes pro-inflammatory cytokine secretion in hepatic stellate cells via NF-κB/STAT3 pathways
Keywords: Hepatic stellate cells (HSCs); NF-kappa B (NF-κB); STAT3; TWEAK; Fn14; Pro-inflammatory cytokines;
Original ArticleFn14·TRAIL fusion protein is oligomerized by TWEAK into a superefficient TRAIL analog
Keywords: Fn14·TRAIL; Fusion protein; TWEAK; Apoptosis; Oligomerization; TRAIL; TNF-related apoptosis-inducing ligand; TWEAK; tumor necrosis factor-like weak inducer of apoptosis; Fn14; fibroblast growth factor-inducible 14-kDa protein; c-FLIP; cellular Fas-associ
The role of TWEAK/Fn14 signaling in the MPTP-model of Parkinson's disease
Keywords: COX-2; cycoloxygenase-2; DOPAC; 3,4-dihydrophenylacetic acid; FN14; fibroblast growth factor-inducible 14; HPLC; high-performance liquid chromatography; HRP; horseradish peroxidase; MPTP; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; NF-κB; nuclear facto
TNF-like weak inducer of apoptosis promotes blood brain barrier disruption and increases neuronal cell death in MRL/lpr mice
Keywords: Systemic lupus erythematous (SLE); Neuropsychiatric lupus (NPSLE); TWEAK; Fn14;
Cytokines in atherosclerosis: Key players in all stages of disease and promising therapeutic targets
Keywords: Atherosclerosis; Cytokines; Chemokines; Inflammation; Therapeutic avenues; ABC; ATP-binding cassette; ACAT-1; acyl-CoA acyl transferase-1; ADRP; adipocyte differentiation related protein; Apo; apolipoprotein; BMT; bone marrow transplantation; CANTOS; Cana
Pathological activation of canonical nuclear-factor κB by synergy of tumor necrosis factor α and TNF-like weak inducer of apoptosis in mouse acute colitis
Keywords: Epithelial cell; Acute colitis; Cytokines; ECs; epithelial cells; Fn14; fibroblast growth factor-inducible molecule 14; LPCs; lamina propria cells; LPS; lipopolysaccharide; mAb; monoclonal antibodies; MLN; mesenteric lymph node; NF; nuclear factor; PBS; p
TWEAK/Fn14 axis: The current paradigm of tissue injury-inducible function in the midst of complexities
Keywords: TWEAK, TNF-like weak inducer of apoptosis; Fn14, FGF-inducible molecule-14; mTWEAK, cell surface membrane TWEAK; sTWEAK, soluble TWEAKTWEAK; Fn14; Tissue injury; Inflammation; Fibrosis; Cancer
Neuropsychiatric disease in murine lupus is dependent on the TWEAK/Fn14 pathway
Keywords: Systemic lupus erythematosus (SLE); Neuropsychiatric lupus; TWEAK; Fn14
TNF-related weak inducer of apoptosis (TWEAK) promotes kidney fibrosis and Ras-dependent proliferation of cultured renal fibroblast
Keywords: Kidney fibrosis; Fn14; TWEAK; Ras; Proliferation; NFκB
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Anti-TWEAK Monoclonal Antibody in Patients With Rheumatoid Arthritis
Keywords: Fn14; pharmacodynamics; pharmacokinetics; TWEAK
DHA reduces the atrophy-associated Fn14 protein in differentiated myotubes during coculture with macrophages
Keywords: DHA, docosahexaenoic acid; EPA, eicosapentaenoic acid; DAG, diacylglycerol; FFA, free fatty acid; MuRF-1, muscle ring-finger protein-1; MafBX, muscle atrophy F-boxDocosahexaenoic acid; Palmitic acid; Muscle atrophy; Fn14; MuRF-1; MAFbx
Research ArticleAlpha-fetoprotein acts as a novel signal molecule and mediates transcription of Fn14 in human hepatocellular carcinoma
Keywords: AFP; alpha fetoprotein; RAR; retinoic acid receptor; ATRA; all trans retinoic acid; HCC; hepatocellular carcinoma; Fn14; fibroblast growth factor-inducible 14; TWEAK; TNF-like weak inducer of apoptosis; Fn14; Hepatoma; All trans retinoic acid; Nuclear rec
Elevated fibroblast growth factor-inducible 14 expression promotes gastric cancer growth via nuclear factor-κB and is associated with poor patient outcome
Keywords: Fn14; Cell growth; NF-κB; Gastric cancer; Anti-apoptosis;
Role of TWEAK in lupus nephritis: A bench-to-bedside review
Keywords: SLE; Lupus nephritis; TWEAK; Fn14
Inhibition of the TWEAK/Fn14 pathway attenuates renal disease in nephrotoxic serum nephritis
Keywords: Systemic lupus erythematosus (SLE); Nephrotoxic serum nephritis; TWEAK; Fn14
Low TWEAK expression is correlated to the progression of squamous cervical carcinoma
Keywords: TWEAK; Fn14; Cervical cancer; Cervical intraepithelial neoplasm (CIN)
Neuroprotective effect of Fn14 deficiency is associated with induction of the granulocyte-colony stimulating factor (G-CSF) pathway in experimental stroke and enhanced by a pathogenic human antiphospholipid antibody
Keywords: aCL; anti-cardiolipin antibody; aPL; antiphospholipid antibody; aPS; anti-phosphatidylserine antibody; APS; antiphospholipid syndrome; eAPS; experimental APS; beta2-GPI; beta2-glycoprotein I; CNS; central nervous system; dMCAO; distal middle cerebral arte
TWEAK/Fn14 promotes apoptosis of human endometrial cancer cells via caspase pathway
Keywords: TWEAK; Fn14; Endometrial cancer; Apoptosis; Caspase
TWEAK stimulation of kidney resident cells in the pathogenesis of graft versus host induced lupus nephritis
Keywords: Fn14; GVH; Macrophages; Systemic lupus erythematosus; TWEAK
TNF-like weak inducer of apoptosis (TWEAK) induces inflammatory and proliferative effects in human kidney cells
Keywords: TWEAK; Fn14; Inflammation; Chemokines; Mesangial cells
TWEAK/Fn14 Pathway: A Nonredundant Role in Intestinal Damage in Mice Through a TWEAK/Intestinal Epithelial Cell Axis
Keywords: Fn14; fibroblast growth factor-inducible molecule 14; Ig; immunoglobulin; IL; interleukin; KC; keratinocyte-derived chemokine; KO; knockout; mAb; monoclonal antibody; MCP; monocyte chemoattractant protein; MMP; matrix metalloproteinase; mRNA; messenger
Induction of the cytokine TWEAK and its receptor Fn14 in ischemic stroke
Keywords: Stroke; Fn14; TWEAK; Cytokine; Apoptosis; Brain edema
Picomole-level mapping of protein disulfides by mass spectrometry following partial reduction and alkylation
Keywords: Disulfide mapping; Disulfide structure determination; Partial reduction and alkylation; TIM-1 IgV; Fn14; TNF receptor family; TIM family;
TWEAKing tissue remodeling by a multifunctional cytokine: Role of TWEAK/Fn14 pathway in health and disease
Keywords: TWEAK; Fn14; Cytokine; Inflammation; Tissue regeneration
TWEAK and Fn14: New molecular targets for cancer therapy?
Keywords: TNF; TWEAK; Fn14; Cancer; Tumor; Endothelial cell; Angiogenesis
Cytokine cooperation in renal tubular cell injury: The role of TWEAK
Keywords: acute renal failure; apoptosis; caspases; Fn14; TWEAK
TWEAK mediates anti-tumor effect of tumor-infiltrating macrophage
Keywords: TWEAK; Fn14; Apoptosis; Tumor; Macrophage;
Anti-TWEAK monoclonal antibodies reduce immune cell infiltration in the central nervous system and severity of experimental autoimmune encephalomyelitis
Keywords: TWEAK; Fn14; Experimental autoimmune encephalomyelitis; Therapy; Neutralizing antibody;
Targeting fibroblast growth factor-inducible-14 signaling protects from chronic relapsing experimental autoimmune encephalomyelitis
Keywords: TWEAK; Fn14; EAE; Multiple sclerosis; Inflammation;