Keywords: FPP، فارسیل پیرو فسفات; DSS, Dang-Shan Suli; FPP, farnesyl pyrophosphate; FW, fresh weight; GC–MS, gas chromatsography–mass spectrometry; GPP, geranyl pyrophosphate; GGPP, geranylgeranyl pyrophosphate; HS-SPME, headspace solid phase microextraction; LOX pathway, lipoxygenase pat
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Keywords: FPP، فارسیل پیرو فسفات; Aβ, amyloid β protein; AD, Alzheimer's disease; ApoE, apolipoprotein E; APP, amyloid precursor protein; BACE1, β-secretase; CI, confidence interval; CN, cognitively normal; FPP, farnesyl pyrophosphate; FTI, farnesyl transferase inhibitor; GGPP, geranylger
Keywords: FPP، فارسیل پیرو فسفات; Bisphosphonates; Clinical trials; Direct anti-cancer effects; Cancer immunology; Hematological malignancies; Solid tumorsAML, acute myeloid leukemia; CML, chronic myeloid leukemia; ATP, adenosine triphosphate; FPP, farnesyl pyrophosphate; HER, human epide
Keywords: FPP، فارسیل پیرو فسفات; ESCs, embryonic stem cells; EBs, embryoid bodies; FPP, farnesyl pyrophosphate; GGPP, geranylgeranyl pyrophosphate; MHC, myosin heavy chain; MLC, myosin light chain; ANP, atrium natriuretic peptideStatin; Myogenesis; Transcription; Cholesterol synthesis; S
Keywords: FPP، فارسیل پیرو فسفات; BMD, bone mineral density; BMP, bone morphogenetic protein; DBBM, demineralized bovine bone matrix; ERα, estrogen receptor-alpha; FPP, farnesyl pyrophosphate; GGPP, geranylgeranyl pyrophosphate; GGPPs, GGPP synthase; HMG-CoA, 3-hydroxy-3-methylglutaryl-co
HMGCR positively regulated the growth and migration of glioblastoma cells
Keywords: FPP، فارسیل پیرو فسفات; HMGCR, HMG-CoA reductase; CTGF, connective tissue growth factor; GBM, glioblastoma; MIB, mevalonate-isoprenoid biosynthesis; FPP, farnesyl pyrophosphate; DCIS, ductal carcinoma-in-situ; YAP, Yes-associated protein; TAZ, transcriptional co-activator with P
Statins inhibited the MIP-1α expression via inhibition of Ras/ERK and Ras/Akt pathways in myeloma cells
Keywords: FPP، فارسیل پیرو فسفات; DMSO, dimethyl sulfoxide; HMG-CoA, 3-hydroxy-3-methylglutaryl-coenzyme A; ERK1/2, extracellular signal-regulated kinase 1/2; FPP, farnesyl pyrophosphate; GGPP, geranylgeranyl pyrophosphate; LPS, lipopolysaccharide; MIP-1α, macrophage inflammatory protein-
Protein prenylation in islet β-cell function in health and diabetes: Putting the pieces of the puzzle together
Keywords: FPP، فارسیل پیرو فسفات; ERK1/2, extracellular signal-related kinase 1/2; Fpp, farnesyl pyrophosphate; FTase, farnesyl transferase; FTase/GGTase-α, common α-subunit of FTase and GGTase; FTI, farnesyl transferase inhibitor; GGpp, geranylgeranyl pyrophosphate; GGTase-I, geranylgera
Overexpression of erg20 gene encoding farnesyl pyrophosphate synthase has contrasting effects on activity of enzymes of the dolichyl and sterol branches of mevalonate pathway in Trichoderma reesei
Keywords: FPP، فارسیل پیرو فسفات; DMAPP, dimethylallylpyrophosphate; erg20, gene encoding FPP synthase; erg9, gene encoding squalene synthase; ERGXX, FPP synthase protein; FPP, farnesyl pyrophosphate; GPP, geranyl pyrophosphate; HMGR, 3-hydroxy-3-methylglutaryl-CoA reductase; IPP, isopent
Molecular regulation of santalol biosynthesis in Santalum album L.
Keywords: FPP، فارسیل پیرو فسفات; cDNA, Complementary DNA; DMAPP, Dimethyl allyl pyrophosphate; FDS, Farnesyl diphosphate synthase; FPP, Farnesyl pyrophosphate; GPP, Geranyl pyrophosphate; IPP, Isopentenyl pyrophosphate; RACE, Rapid amplification of cDNA ends; SS, Santalene synthase; Sa,
Molecular cloning and expression of Hedychium coronarium farnesyl pyrophosphate synthase gene and its possible involvement in the biosynthesis of floral and wounding/herbivory induced leaf volatile sesquiterpenoids
Keywords: FPP، فارسیل پیرو فسفات; FPPS, farnesyl pyrophosphate synthase; DMAPP, dimethylallyl pyrophosphate; FPP, farnesyl pyrophosphate; GC–MS, gas chromatography–mass spectrometry; GPP, geranyl pyrophosphate; IPP, isopentenyl pyrophosphate; DXP, 1-deoxyxylulose-5-phosphateFarnesyl pyrop
Statins, autophagy and cancer metastasis
Keywords: FPP، فارسیل پیرو فسفات; Atg, autophagy-related genes; AMPK, AMP-dependent protein kinase; ECM, extracellular matrix; ER, endoplasmic reticulum; FPP, farnesyl pyrophosphate; GGPP, geranylgeranyl pyrophosphate; HDAC, histone deacetylase; HMG-CoA, 3-hydroxy-3-methylglutaryl coenzym
Atorvastatin preserves the integrity of endothelial adherens junctions by inhibiting vascular endothelial cadherin tyrosine phosphorylation
Keywords: FPP، فارسیل پیرو فسفات; VE-cad, vascular endothelial cadherin; Tyr, tyrosine; ECs, endothelial cells; AJs, adherens junctions; IL-1β, interleukin-1β; MLC, myosin light chain; TEM, transendothelial migration; Pyk2, proline-rich tyrosine kinase 2; FPP, farnesyl pyrophosphate; GGPP
Inhibition of the isoprenoid biosynthesis pathway; detection of intermediates by UPLC–MS/MS
Keywords: FPP، فارسیل پیرو فسفات; DMAPP, dimethylallyl pyrophosphate; DMEM, Dulbecco's Modified Eagles Medium; FCS, fetal calf serum; FMVA, 6-fluoromevalonate; FPP, farnesyl pyrophosphate; FPPS, farnesyl pyrophosphate synthase; FTI, farnesyltransferase inhibitor; GGPP, geranylgeranyl pyro
Molecular cloning and expression of Chimonanthus praecox farnesyl pyrophosphate synthase gene and its possible involvement in the biosynthesis of floral volatile sesquiterpenoids
Keywords: FPP، فارسیل پیرو فسفات; Farnesyl pyrophosphate synthase; Heterologous expression; Sesquiterpenoid biosynthesis; WintersweetCLD, chain length determination; DMAPP, dimethylallyl pyrophosphate; FARM, first Asp-rich motif; FPP, farnesyl pyrophosphate; GC–MS, gas chromatography–mass
Design of more potent squalene synthase inhibitors with multiple activities
Keywords: FPP، فارسیل پیرو فسفات; SQS, squalene synthase; HMG-CoA, 3-hydroxy-3-methylglutaryl-CoA; FPP, farnesyl pyrophosphate; BSA, bovine serum albumin; NADPH, nicotinamide adenine dinucleotide phosphate; IC50, inhibitory concentration (for 50% of the reaction); TC, total cholesterol; L
Role for protein geranylgeranylation in adult T-cell leukemia cell survival
Keywords: FPP، فارسیل پیرو فسفات; ATL, adult T-cell leukemia; FPP, farnesyl pyrophosphate; FTI, farnesyltransferase inhibitor; FTase, farnesyltransferase; GGPP, geranylgeranyl pyrophosphate; GGTase, geranylgeranyltransferase; GGTI, geranylgeranyltransferase inhibitor; HTLV-I, human T-cell
The HMG-CoA reductase inhibitor rosuvastatin inhibits plasminogen activator inhibitor-1 expression and secretion in human adipocytes
Keywords: FPP، فارسیل پیرو فسفات; Adip., primary human adipocyte; da, dominant active; dn, dominant negative; FPP, farnesyl pyrophosphate; GGPP, geranylgeranyl pyrophosphate; IκB, inhibitor of NFκB; MAPK, mitogen-activated protein kinase; MEKK-1, mitogen-activated protein kinase kinase ki
Lovastatin inhibits oxidized low-density lipoprotein-induced plasminogen activator inhibitor and transforming growth factor-β1 expression via a decrease in Ras/extracellular signal-regulated kinase activity in mesangial cells
Keywords: FPP، فارسیل پیرو فسفات; cDNA, complementary DNA; DMEM, Dulbecco’s modified Eagle’s medium; ECM, extracellular matrix; ELISA, enzyme-linked immunosorbent assay; ERK, extracellular signal-regulated kinase; FCS, fetal calf serum; FPP, farnesyl pyrophosphate; GDP, guanosine diphosph
Protein geranylgeranyltransferase-I of Trypanosoma cruzi
Keywords: FPP، فارسیل پیرو فسفات; PGGT-I, protein geranylgeranyltransferase type-I; PFT, protein farnesyltransferase; PGGT-II, protein geranylgeranyltransferase type-II; T. cruzi, Trypanosoma cruzi; GGPP, geranylgeranyl pyrophosphate; FPP, farnesyl pyrophosphate; Sf9, Spodoptera frugiperd
Protein dolichylation in Plasmodium falciparum
Keywords: FPP، فارسیل پیرو فسفات; cys, cysteine; dol, dolichol; ESI-MS, electrospray-ionization mass spectrometry; FPP, farnesyl pyrophosphate; GG, geranylgeraniol; GGPP, geranylgeranyl pyrophosphate; MS/MS, tandem mass spectrometry; m/z, mass quantity/charge number; PBS, phosphate-buffer
HMG–CoA reductase inhibitors upregulate heme oxygenase-1 expression in murine RAW264.7 macrophages via ERK, p38 MAPK and protein kinase G pathways
Keywords: FPP، فارسیل پیرو فسفات; AP-1, Activator protein 1; 8BrcGMP, 8-Bromo-cyclic guanosine monophosphate; dBcGMP, Dibutyryl 3′,5′-cyclic guanosine monophosphate; CO, Carbon monoxide; ERK, Extracellular signal-regulated kinase; FPP, Farnesyl pyrophosphate; GGPP, Geranylgeranyl pyrophos
Effect of supplementing terpenoid biosynthetic precursors on the accumulation of bilobalide and ginkgolides in Ginkgo biloba cell cultures
Keywords: FPP، فارسیل پیرو فسفات; BB, bilobalide; GA, ginkgolide A; GB, ginkgolide B; MVA pathway, mevalonate pathway; MEP pathway, 2-methyl-d-erythritol-4-phosphate pathway; HMG-CoA, 3-hydroxy-3-methylglutaryl-CoA; MVA, mevalonate; FPP, farnesyl pyrophosphate; GA-3P, glyceraldehyde-3 pho
A carotenoid synthesis gene cluster from a non-marine Brevundimonas that synthesizes hydroxylated astaxanthin
Keywords: FPP، فارسیل پیرو فسفات; crt, carotenoid synthesis gene; HPLC, high pressure liquid chromatography; MS, mass spectrometry; FPP, farnesyl pyrophosphate; GGPP, geranylgeranyl pyrophosphateβ-carotene 4,4′-ketolase; β-carotene 3,3′-hydroxylase; β-carotene 2,2′-hydroxylase; Substrate
Secretory phospholipase A2 of group IIA: Is it an offensive or a defensive player during atherosclerosis and other inflammatory diseases?
Keywords: FPP، فارسیل پیرو فسفات; C/EBP-β, CAAT-enhancer-binding protein-β; cPLA2, cytosolic phospholipase A2; ERK, extracellular signal-regulated kinase; FPP, farnesyl pyrophosphate; FTI, farnesyl transferase inhibitor; GGPP, geranylgeranyl pyrophosphate; GGTI, geranylgeranyl transferase