Keywords: طراحی مبتنی بر قطعه; Fragment-based drug design; Anti-neuroinflammation; Alzheimer's disease;
مقالات ISI طراحی مبتنی بر قطعه (ترجمه نشده)
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در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
Keywords: طراحی مبتنی بر قطعه; hMAO; Isoforms selectivity; Fragment-based drug design; Resveratrol; 2H-chromen-2-one;
Keywords: طراحی مبتنی بر قطعه; Fragment-based drug design; Fragment library; Size of chemical space; Properties of fragment hits; 3D fragments;
Design and synthesis of novel 6-hydroxy-4-methoxy-3-methylbenzofuran-7-carboxamide derivatives as potent Mnks inhibitors by fragment-based drug design
Keywords: طراحی مبتنی بر قطعه; 6-Hydroxy-4-methoxy-3-methylbenzofuran-7-carboxamide derivatives; Fragment-based drug design; Anti-proliferative effects; Mnks inhibitors;
Design, synthesis and bioevalucation of novel 2,3-dihydro-1H-inden-1-amine derivatives as potent and selective human monoamine oxidase B inhibitors based on rasagiline
Keywords: طراحی مبتنی بر قطعه; hMAO-B; Isoform selectivity; Fragment-based drug design; Structure activity relationship;
In silico fragment-based drug design with SEED
Keywords: طراحی مبتنی بر قطعه; Fragment-based drug design; Fragment docking; SEED; X-ray crystallography; Screening cascade; SEED2XR;
Recent advances of RAF (rapidly accelerated fibrosarcoma) inhibitors as anti-cancer agents
Keywords: طراحی مبتنی بر قطعه; MAPK; RAF inhibitors; Anti-cancer agents; Abl; Abelson murine leukemia viral oncogene; ATP; Adenine triphosphate; Bcl-2; B-cell lymphoma; CNS; Central nervous system; COX-2; Cyclo-oxygenase enzyme-2; CR; Conserved region; CRD; Cysteine-rich domain; DFG; A
Discovery of BAZ2A bromodomain ligands
Keywords: طراحی مبتنی بر قطعه; BAZ2A bromodomain; Fragment-based drug design; High-throughput docking; Ligand-observed NMR spectroscopy; Protein X-ray crystallography; BAZ2A; bromodomain adjacent to zinc finger domain protein 2A; BAZ2B; bromodomain adjacent to zinc finger domain 2B; BE
NMR in drug design
Keywords: طراحی مبتنی بر قطعه; Fragment-based drug design; Fragment-based screening; Ligand binding; NMR spectroscopy; Temperature shift coefficients; Saturation transfer difference; Chemical shift perturbation; WaterLOGSY; T2 difference; Millamolecule; Ligand-protein interaction; Hit
From carbohydrates to drug-like fragments: Rational development of novel α-amylase inhibitors
Keywords: طراحی مبتنی بر قطعه; α-Amylase inhibition; Fragment-based drug design; Virtual screening; Pharmacophore model; Hyperglycaemia; Obesity; Type II diabetes
A fluorescent approach for identifying P2X1 ligands
Keywords: طراحی مبتنی بر قطعه; Fluorescent; Ligand binding; Ligand gated ion channel; P2X1; Fragment-based drug discovery; Pharmacology; NF449; Alexa-647; FBDD; Fragment-based drug design; ATP; Adenosine triphosphate; SCA; Scaffold classification approach;
Fragment-based approach to the design of 5-chlorouracil-linked-pyrazolo[1,5-a][1,3,5]triazines as thymidine phosphorylase inhibitors
Keywords: طراحی مبتنی بر قطعه; 5-Chlorouracil-linked-pyrazolo[1,5-a][1,3,5]triazines; Thymidine phosphorylase inhibitor; Fragment-based drug design; Mixed-type enzyme inhibition kinetics;
Fragment-based drug design and identification of HJC0123, a novel orally bioavailable STAT3 inhibitor for cancer therapy
Keywords: طراحی مبتنی بر قطعه; Fragment-based drug design; Anticancer agents; Drug discovery; STAT3; Breast cancerFBDD, fragment-based drug design; STATs, signal transducers and activators of transcription; ER, estrogen receptor; HBTU, 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluroniu
X-ray and molecular modelling in fragment-based design of three small quinoline scaffolds for HIV integrase inhibitors
Keywords: طراحی مبتنی بر قطعه; SHOHIXCIFBPUAP-UHFFFAOYSA-N; UZRKHXBGSOMEOH-UHFFFAOYSA-N; VUKWLYLGIHTCKZ-UHFFFAOYSA-N; HIV integrase; Quinolines; Fragment-based drug design; Crystal structure;
The rational design of a novel potent analogue of the 5′-AMP-activated protein kinase inhibitor compound C with improved selectivity and cellular activity
Keywords: طراحی مبتنی بر قطعه; Fragment-based drug design; FBDD; 5′-AMP-activated protein kinase; AMPK; Compound C
Structure-guided expansion of kinase fragment libraries driven by support vector machine models
Keywords: طراحی مبتنی بر قطعه; FBDD; fragment-based drug design; SBDD; structure-based drug design; QSAR; quantitative structure activity relationship; SVM-FP; support vector machine-fingerprints; PPV; positive predicted value; LE; ligand efficiency; HAC; heavy atom count; AMW; atomi
Ligand- and substrate-based 19F NMR screening: Principles and applications to drug discovery
Keywords: طراحی مبتنی بر قطعه; ALARM; a La assay to detect reactive molecules; BEI; binding efficiency index; CPMG; Carr-Purcell-Meiboom-Gill; CSA; chemical shift anisotropy; ERETIC; electronic reference to access in vivo concentrations; FA; fluorescence anisotropy; FABS; fluorin