Inhibition of the rat brain sodium channel Nav1.2 after prolonged exposure to gabapentin
Keywords: گاباپنتین; Gabapentin; Anticonvulsant; Patch clamp; Nav1.2; Prolonged exposure
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Clinical Presentation, Quantitative Sensory Testing, and Therapy of 2 Patients with Fourth Thoracic Syndrome
Keywords: گاباپنتین; Paresthesia; Thoracic Vertebrae; Manipulation, Spinal; Pain Measurement; Gabapentin
α2δ and the mechanism of action of gabapentin in the treatment of pain
Keywords: گاباپنتین; α2δ, calcium channel subunit; GABA, γ-aminobutyric acid gamma; GAT1, GABA transporter; DRG, dorsal root gangliaReview; Gabapentin; Pregabalin; Neurontin; Lyrica; Voltage gated calcium channel; Review; Pain
(l)-Phenylglycine, but not necessarily other α2δ subunit voltage-gated calcium channel ligands, attenuates neuropathic pain in rats
Keywords: گاباپنتین; Gabapentin; Pregabalin; Phenylglycine; Allodynia; Analgesia; Brain; Spinal nerve ligation
Multiple dose gabapentin attenuates cutaneous pain and central sensitisation but not muscle pain in healthy volunteers
Keywords: گاباپنتین; Gabapentin; Hyperalgesia; Hypertonic saline; Electric stimulation; Pain; Human experimental
K+-evoked [3H]-norepinephrine release in human brain slices from epileptic and non-epileptic patients is differentially modulated by gabapentin and pinacidil
Keywords: گاباپنتین; Gabapentin; Pinacidil; Epilepsy; Calcium channels; KATP channels
Gabapentin depresses C-fiber-evoked field potentials in rat spinal dorsal horn only after induction of long-term potentiation
Keywords: گاباپنتین; Hypersensitivity; C-fibers; Field potentials; Long-term potentiation; Spinal dorsal horn; Gabapentin; Morphine
Measuring the effects of antiepileptic medications on balance in older people
Keywords: گاباپنتین; Lamotrigine; Gabapentin; Carbamazepine; Posturography; Balance; Ataxia; Equilibrium; Dizziness;
Determination of gabapentin in human plasma and urine by high-performance liquid chromatography with UV–vis detection
Keywords: گاباپنتین; Gabapentin; NQS; Biological fluids; HPLC
Surgically induced osteoarthritis in the rat results in the development of both osteoarthritis-like joint pain and secondary hyperalgesia
Keywords: گاباپنتین; Osteoarthritis; Medial meniscal tear; Secondary hyperalgesia; COX-2 inhibitor; Gabapentin; Rat; Allodynia
Randomized, placebo-controlled trial of baclofen and gabapentin for the treatment of methamphetamine dependence
Keywords: گاباپنتین; Methamphetamine dependence; Randomized clinical trial; Baclofen; Gabapentin
A randomized placebo-controlled trial of gabapentin for cocaine dependence
Keywords: گاباپنتین; Cocaine dependence; Pharmacotherapy trials; Gabapentin; Relapse-prevention therapy; Placebo lead-in
The acute effects of gabapentin in combination with alcohol in heavy drinkers
Keywords: گاباپنتین; Gabapentin; GABA; Alcohol response; Alcohol craving; Heavy drinkers
Targeting N-type and T-type calcium channels for the treatment of pain
Keywords: گاباپنتین; Drug Discovery; Pharmaceutical Science; Cell biology; Neurobiologyneuron; calcium channel; ion channel; inflammation; Prialt; Gabapentin; nociception
The nitric oxide-cyclic GMP-protein kinase G-K+ channel pathway participates in the antiallodynic effect of spinal gabapentin
Keywords: گاباپنتین; Gabapentin; Neuropathic pain; Nitric oxide; Guanylyl cyclase; Protein kinase G; K+ channel opener; Diazoxide; Pinacidil
Rapid quantification of gabapentin in human plasma by liquid chromatography/tandem mass spectrometry
Keywords: گاباپنتین; Gabapentin; 1,1-Cyclohexane diacetic acid monoamide (CAM); Liquid chromatography/tandem mass spectrometry; Human plasma; Pharmacokinetic study
Differential pharmacological modulation of the spontaneous stimulus-independent activity in the rat spinal cord following peripheral nerve injury
Keywords: گاباپنتین; Neuropathic pain; NMDA receptor antagonist; Morphine; Gabapentin; Mepyramine; Central sensitization
Economic Evaluation of Oral Treatments for Neuropathic Pain
Keywords: گاباپنتین; Neuropathic pain; cost-utility; amitriptyline; carbamazepine; gabapentin; tramadol
CHF3381, a N-methyl-D-aspartate Receptor Antagonist and Monoamine Oxidase–A Inhibitor, Attenuates Secondary Hyperalgesia in a Human Pain Model
Keywords: گاباپنتین; CHF3381; gabapentin; secondary hyperalgesia; pain model
The Analgesic Effects of Perioperative Gabapentin on Postoperative Pain: A Meta-Analysis
Keywords: گاباپنتین; Analgesia; Gabapentin; Meta-Analysis; Opioid; Preemptive; Surgery;
Gabapentin and postoperative pain – a systematic review of randomized controlled trials
Keywords: گاباپنتین; Systematic review; Meta-analysis; Pain; Analgesia; Surgery; Postoperative; Gabapentin
Development and expression of neuropathic pain in CB1 knockout mice
Keywords: گاباپنتین; Allodynia; CB1 cannabinoid receptors; Gabapentin; Hyperalgesia; Neuropathic pain
Quantitative determination of vigabatrin and gabapentin in human serum by gas chromatography-mass spectrometry
Keywords: گاباپنتین; GC-MS; Anti-epileptics; Vigabatrin; Gabapentin;
Gabapentin-Induced Myopathy in 2 Patients on Short Daily Hemodialysis
Keywords: گاباپنتین; Gabapentin; hemodialysis (HD); myopathy; daily;
Improving opioid effectiveness: from ideas to evidence
Keywords: گاباپنتین; Opioid; Non-steroidal anti-inflammatory; N-methyl-d-aspartate; Gabapentin; α2-Adrenergic;
Efectividad de la gabapentina en el tratamiento de la espasticidad: estudio aleatorizado, a doble ciego y controlado con placebo
Keywords: گاباپنتین; Espasticidad; Ensayo clÃnico; Motoneurona superior; Gabapentina; Spasticity; Clinical trial; Upper motoneuron; Gabapentin;
Effect of L-type calcium channel antagonists on spermine-induced CNS excitation in vivo
Keywords: گاباپنتین; Spermine; L-type calcium channel; Dihydropyridine; Verapamil; Gabapentin; NMDA receptor;
Effect of systemic and intrathecal gabapentin on allodynia in a new rat model of postherpetic neuralgia
Keywords: گاباپنتین; Sensory systems; Pain modulation, pharmacology; Neuropathic pain; Postherpetic neuralgia; Anticonvulsants; Hyperalgesia; Gabapentin; Spinal cord;
Effects of gabapentin on spontaneous discharges and subthreshold membrane potential oscillation of type A neurons in injured DRG
Keywords: گاباپنتین; Gabapentin; Spontaneous discharge; Subthreshold membrane potential oscillation; Dorsal root ganglion; Neuropathic pain;
Attenuation of morphine tolerance by intrathecal gabapentin is associated with suppression of morphine-evoked excitatory amino acid release in the rat spinal cord
Keywords: گاباپنتین; Neurotransmitters, modulators, transporters, and receptors; Opioids: anatomy, physiology, and behavior; Gabapentin; Morphine; Drug tolerance; Excitatory amino acid;
Pharmacological evaluation of the selective spinal nerve ligation model of neuropathic pain in the rat
Keywords: گاباپنتین; Sham; sham surgery; L5SNL; L5 spinal nerve ligation-vehicle; GP-30; gabapentin 30Â mg/kg; GP-60; gabapentin 60Â mg/kg; GP-120; gabapentin 120Â mg/kg; MOR1; morphine 1Â mg/kg; MOR3; morphine 3Â mg/kg; MOR6; morphine 6Â mg/kg; AMI1.5; amitriptyline 1.5Â mg/
Synergistic interaction of gabapentin and oxcarbazepine in the mouse maximal electroshock seizure model-an isobolographic analysis
Keywords: گاباپنتین; Oxcarbazepine; Gabapentin; Electroshock maximal; Isobolographic analysis; Pharmacodynamic interaction; Seizure;
The synthesis of baclofen and GABOB via Rh(II) catalyzed intramolecular C-H insertion of α-diazoacetamides
Keywords: گاباپنتین; C-H Insertion; γ-Lactam; Gabapentin; Baclofen; GABA;
The novel GABA adamantane derivative (AdGABA): design, synthesis, and activity relationship with gabapentin
Keywords: گاباپنتین; AdGABA; Ca2+ channels; Gabapentin; Anticonvulsant
Effects of antiepileptic drugs on attention as assessed by a five-choice serial reaction time task in rats
Keywords: گاباپنتین; Attention; Five-choice serial reaction time performance; Antiepileptic drugs; Phenobarbital; Tiagabine; Gabapentin; Valproate; Topiramate; Lamotrigine; Carbamazepine; Phenytoin;
Bupropion-induced convulsions: Preclinical evaluation of antiepileptic drugs
Keywords: گاباپنتین; Bupropion; Seizures; Antiepileptic drugs; Clonazepam; Gabapentin; Smoking cessation;
Effects of amitriptyline and gabapentin on bilateral hyperalgesia observed in an animal model of unilateral axotomy
Keywords: گاباپنتین; Bilateral hyperalgesia; Axotomy; Sciatic nerve; Saphenous nerve; Amitriptyline; Gabapentin;
A placebo-controlled randomized clinical trial of perioperative administration of gabapentin, rofecoxib and their combination for spontaneous and movement-evoked pain after abdominal hysterectomy
Keywords: گاباپنتین; Gabapentin; Rofecoxib; Postoperative pain; Movement-evoked pain; Hysterectomy;
Behavioral and pharmacological characterization of a distal peripheral nerve injury in the rat
Keywords: گاباپنتین; CCI; chronic constriction injury; DNI; distal nerve injury; DRG; dorsal root ganglion; SNI; spared nerve injury; SNL; spinal nerve ligation; TCA; tricyclic antidepressant; Antinociception; Gabapentin; Imipramine; Morphine; Neuropathic pain; Plantar nerve;
Carrier-mediated transport to enhance drug delivery to brain
Keywords: گاباپنتین; 1/Km; Apparent affinity; BBB; Blood-brain barrier; GLUT1; Glucose transporter-1; Jin=brain influx rate; Ki; transport inhibition constant (â¼ equivalent to IC50); Km; Michaelis constant; LAT1; Large neutral amino acid transporter-1; MCT1; Monocarboxyli
Pregabalin in neuropathic pain: A more “pharmaceutically elegant” gabapentin?
Keywords: گاباپنتین; pregabalin; gabapentin; neuropathic pain; postherpetic neuralgia; diabetic neuropathy;
Varicella zoster virus induces neuropathic changes in rat dorsal root ganglia and behavioral reflex sensitisation that is attenuated by gabapentin or sodium channel blocking drugs
Keywords: گاباپنتین; Post-herpetic neuralgia; Varicella zoster virus; Dorsal root ganglia; Sodium channels; Neuropeptide Y; Galanin; Gabapentin;
Tumor-induced injury of primary afferent sensory nerve fibers in bone cancer pain
Keywords: گاباپنتین; Tumor; Skeletal malignancies; Gabapentin; Nerve injury; Metastasis; Nociception;