Keywords: Thioredoxins; Cholestasis; Oxidative stress; Cholangiocyte; ALT; Alanine aminotransferase; BDL; Bile duct ligation; GCLC; Gamma-glutamylcysteine; GSH; Reduced glutathione; GST; Glutathione S-Transferase; HO-1; Heme Oxygenase 1; 4-HNE; 4-hydroxy-2-nonenal;