Keywords: GC، guanylyl cyclase; COX-2, cyclooxygenase; CXCR4, CXC chemokine receptor 4; ECM, extracellular matrix; ELAM-1, endothelial leukocyte adhesion molecule 1; eNOS, endothelial nitric oxide synthase; GC, guanylyl cyclase; HIF-1, hypoxia-inducible factor-1; HUVECs, human umbilical
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Keywords: GC، guanylyl cyclase; β-ARs, β-adrenergic receptors; BSA, bovine serum albumin; CAs, catecholamines; CgA, Chromogranin A; CO, cardiac output; CST, Catestatin; ET-1, Endothelin-1; ETAR, ET-1 type A receptors; ETBR, ET-1 type B receptors; GC, guanylyl cyclase; HR, heart rate; NO
Phosphodiesterase 5/protein kinase G signal governs stemness of prostate cancer stem cells through Hippo pathway
Keywords: GC، guanylyl cyclase; Cancer stem cells; Stemness; PDE5; Hippo pathway; TAZ5'-GMP, guanosine-5'-monophosphate; cGMP, cyclic guanosine monophosphate; CSCs, cancer stem cells; ED, erectile dysfunction; eNOS, endothelial NOS; GC, guanylyl cyclase; iNOS, inducible NOS; LATS, nucle
cGMP signaling as a target for the prevention and treatment of breast cancer
Keywords: GC، guanylyl cyclase; cAMP, cyclic adenosine monophosphate; cGMP, cyclic guanosine monophosphate; PKG, cGMP-dependent protein kinase; CNG, cyclic nucleotide gated ion channel; COX, cyclooxygenase; GTP, guanosine triphosphate; GMP, guanosine monophosphate; GC, guanylyl cyclase;
Structure, mechanism, and regulation of soluble adenylyl cyclases — similarities and differences to transmembrane adenylyl cyclases
Keywords: GC، guanylyl cyclase; AC, adenylyl cyclase; ApCpp, α,β-methylene-adenosine-5′-triphosphate; ATPαS, adenosine-5′-α-thio-triphosphate; CE, catechol estrogen; DIDS, 4,4′-diisothiocyanatostilbene-2,2′-disulfonic acid; Gβγ, G protein, β and γ subunits; GC, guanylyl cyclase; Gsα, st
Inorganic nitrite stimulates pancreatic islet blood flow and insulin secretion
Keywords: GC، guanylyl cyclase; GC, guanylyl cyclase; HBSS, Hank's balanced salt solution; IBF, islet blood flow; IPGTT, intraperitoneal glucose tolerance test; NO, nitric oxide; NOS, nitric oxide synthase; PKG, protein kinase G; ROS, reactive oxygen species.Islet; Insulin secretion; Ni
Nitric oxide is involved in hemin-induced cucumber adventitious rooting process
Keywords: GC، guanylyl cyclase; cGMP, cyclic guanosine monophosphate; cPTIO, 2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide potassium salt; CO, carbon monoxide; GC, guanylyl cyclase; HO-1, heme oxygenase-1; l-NAME, NG-nitro-l-arginine methylester hydrochloride; l-NNA,
The CHH-superfamily of multifunctional peptide hormones controlling crustacean metabolism, osmoregulation, moulting, and reproduction
Keywords: GC، guanylyl cyclase; AG, androgenic gland; CHH, crustacean hyperglycaemic hormone; CPRP, crustacean hyperglycaemic hormone precursor-related peptide; DA, dopamine; ES, eyestalk; GC, guanylyl cyclase; GIH, gonad-inhibiting hormone; GPCR, G-protein coupled receptor; 5-HT, 5-hyd
Identification of NO/sGC signalling in the bulbospinal respiratory pathway after C2–C3 hemisection of the spinal cord in rats
Keywords: GC، guanylyl cyclase; cGMP, cyclic guanosine monophosphate; CPP, crossed phrenic phenomenon; DRG, dorsal respiratory group; FG, Fluorogold; GC, guanylyl cyclase; NADPHd, nicotinamide adenine dinucleotide phosphate diaphorase; nNOS, neuronal nitric oxide synthase; NO, nitric ox
Nitric oxide affects IL-6 expression in human peripheral blood mononuclear cells involving cGMP-dependent modulation of NF-κB activity
Keywords: GC، guanylyl cyclase; IL-6; NF-κB; Nitric oxide; cGMP; PBMCEMSA, electrophoretic mobility shift assay; GC, guanylyl cyclase; GSNO, S-nitrosoglutathione; IBMX, 3-isobutyl-1-methylxanthine; ODQ, 1H-[1,2,4]oxadiazolo[4,3-α]quinoxalin-1-one; PDE, phosphodiesterase; PKG, cGMP-depen
Pharmacological evidence that Ca2+ channels and, to a lesser extent, K+ channels mediate the relaxation of testosterone in the canine basilar artery
Keywords: GC، guanylyl cyclase; AC, adenylyl cyclase; cAMP, 3′,5′-cyclic adenosine monophosphate; cGMP, 3′,5′-cyclic guanosine monophosphate; DMSO, dimethyl sulfoxide; GC, guanylyl cyclase; ODQ, 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one; SNP, sodium nitroprusside; SQ 22,536, [9-(tetra
cGMP/PKG pathway mediates myocardial postconditioning protection in rat hearts by delaying normalization of intracellular acidosis during reperfusion
Keywords: GC، guanylyl cyclase; GC, guanylyl cyclase; KHB, Krebs–Henseleit bicarbonate buffer; LDH, lactate dehydrogenase; LVEDP, left ventricular end-diastolic pressure; LVdevP, left ventricular developed pressure; mPTP, mitochondria permeability transition pore; NBC, Na+/HCO3− symport
Different effects of soluble and particulate guanylyl cyclases on expression of inflammatory cytokines in rat peripheral blood mononuclear cells
Keywords: GC، guanylyl cyclase; ANP, atrial natriuretic peptide; AP-1, activator protein-1; CNP, C-type natriuretic peptide; EMSA, electrophoretic mobility shift assay; GC, guanylyl cyclase; IBMX, 3-isobutyl-1-methylxanthine; ODQ, 1H-[1,2,4]oxadiazolo[4,3-α]quinoxalin-1-one; NF-κB, nucl
Atypical guanylyl cyclase from the pond snail Lymnaea stagnalis: cloning, sequence analysis and characterization of expression
Keywords: GC، guanylyl cyclase; identified neuron; cerebral giant cell; mollusc; nitric oxide; oxygen sensorCGC, cerebral giant cell; GC, guanylyl cyclase; NO, nitric oxide; NOS, NO synthase; RACE, rapid amplification of cDNA ends; RPeD1, right pedal dorsal one; RT-PCR, reverse transcri
Neuronal differentiation of NG108-15 cells has impact on nitric oxide- and membrane (natriuretic peptide receptor-A) cyclic GMP-generating proteins
Keywords: GC، guanylyl cyclase; ANP, atrial natriuretic peptide; CNP, C-type natriuretic peptide; CNPase, 2′,3′-cyclic nucleotide 3′-phosphodiesterase; DMSO, dimethyl sulfoxide; DSS, disuccinimidyl suberate; GFAP, glial fibrillary acidic protein; GC, guanylyl cyclase; IBMX, 1-methyl-3-i
Somatostatin receptors 1 and 5 heterodimerize with epidermal growth factor receptor: Agonist-dependent modulation of the downstream MAPK signalling pathway in breast cancer cells
Keywords: GC، guanylyl cyclase; AC, adenylyl cyclase; AR, amphiregulin; BS3, bis(sulfosuccinimidyl) suberate; BTC, betacellulin; EGF, epidermal growth factor; EPR, epiregulin; ER, oestrogen receptor; ErbBs, epidermal growth factor receptors; GC, guanylyl cyclase; GPCR, guanosine triphos
Transduction mechanisms of photoreceptor signals in plant cells
Keywords: GC، guanylyl cyclase; cAMP, adenosine-3′,5′-cyclophosphate or 3′,5′-cyclo-AMP; AMP, adenosine-5′-monophosphate; GMP, guanosine monophosphate; GTP, guanosine triphosphate; GC, guanylyl cyclase; IP3, inositol-1,4,5-triphosphate; PIP2, phosphatidylinositol-4,5-diphosphate; phy, p
Atrial Natriuretic Peptide Attenuates Hypoxia Induced Chemoresistance in Prostate Cancer Cells
Keywords: GC، guanylyl cyclase; prostate; prostatic neoplasms; drug resistance; atrial natriuretic factor; anoxiaANP, atrial natriuretic peptide; ERK, extracellular receptor kinase; cGMP, cyclic guanosine monophosphate; GC, guanylyl cyclase; GTN, glyceryl trinitrate; NO, nitric oxide; N
Expression and activity of cGMP-dependent phosphodiesterases is up-regulated by lipopolysaccharide (LPS) in rat peritoneal macrophages
Keywords: GC، guanylyl cyclase; EHNA, erythro-9-(2-hydroxy-3-nonyl)adenine; GC, guanylyl cyclase; HBSS, Hank's balanced salt solution; IBMX, 3-isobutyl-1-methylxanthine; PDE, phosphodiesterase; PEM, peritoneal exudate macrophage; PMSF, phenylmethylsulfonyl fluoride; RPM, resident perito
Modulation of synaptic and channel activities in the respiratory network of the mice by NO/cGMP signalling pathways
Keywords: GC، guanylyl cyclase; CaL, L-type Ca2+ channels; DCF, carboxy-H2CFDA;GC, guanylyl cyclase; IR-DIC, infrared differential interference contrast; KATP, ATP-sensitive K+ channels; NMMA, N-monomethyl-l-arginine; NOS, NO synthase; NTS, nucleus tractus solitarii; ODQ, guanylyl cycla
Carbon monoxide counteracts the inhibition of seed germination and alleviates oxidative damage caused by salt stress in Oryza sativa
Keywords: GC، guanylyl cyclase; CAT, catalase; CO, carbon monoxide; GC, guanylyl cyclase; Hb, hemoglobin; HO, heme oxygenase; NBT, nitroblue tetrazolium; NO, nitric oxide; PVP, polyvinylpyrrolidone; ROS, reactive oxygen species; SOD, superoxide dismutase; TBARS, thiobarbituric acid reac
A Structural Basis for the Role of Nucleotide Specifying Residues in Regulating the Oligomerization of the Rv1625c Adenylyl Cyclase from M. tuberculosis
Keywords: GC، guanylyl cyclase; nucleotide cyclase; Mycobacterium tuberculosis; cAMP; crystal structureAC, adenylyl cyclase; GC, guanylyl cyclase; GST, glutathione-S-transferase; PDB, Protein Data Bank
Alterations of the expression and activity of midbrain nitric oxide synthase and soluble guanylyl cyclase in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonism in mice
Keywords: GC، guanylyl cyclase; neuronal nitric oxide synthase; guanylyl cyclase; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Parkinson’s disease; substantia nigra pars compactacGMP, guanosine 3′,5′-cyclic monophosphate; DA-ergic, dopaminergic; GC, guanylyl cyclase; GCβ1, guanylyl cyc
Molecular Details of cAMP Generation in Mammalian Cells: A Tale of Two Systems
Keywords: GC، guanylyl cyclase; AC, adenylyl cyclase; α,β-Me-ATP, α,β-methylene-adenosine-5′-triphosphate; ATPαS, adenosine-5′-α-thio-triphosphate; FRET, fluorescence resonance energy transfer; GC, guanylyl cyclase; Gβγ, G protein, β and γ subunits; Gsα, stimulatory G protein, α subunit