Keywords: GCL، لیگاز سیتست گلوتامات; CI, confidence interval; DNA, deoxyribonucleic acid; dNTP, deoxy-nucleotide-tri phosphate; DSM-IV-TR, diagnostic and statistical manual of mental disorders; EDTA, ethylenediaminetetraacetic acid; GCL, glutamate cysteine ligase; GCLC, glutamate cysteine li
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Rice protein suppresses ROS generation and stimulates antioxidant gene expression via Nrf2 activation in adult rats
Keywords: GCL، لیگاز سیتست گلوتامات; ALT, alanine transaminase; ARE, antioxidant response element; AST, aspartate transaminase; CAS, casein; CAS-C, cholesterol-supplemented casein; GCL, glutamate cysteine ligase; GCLC, glutamate cysteine ligase catalytic subunit; GCLM, glutamate cysteine lig
Nrf2 silencing to inhibit proteolytic defense induced by hyperthermia in HT22 cells
Keywords: GCL، لیگاز سیتست گلوتامات; ARE, Antioxidant Response Element; DNPH, 2,4-Dinitrophenylhydrazine; GAPDH, Glyceraldehyde 3-Phosphate Dehydrogenase; GCL, Glutamate Cysteine Ligase; GST, Glutathione S-Transferase; HDAC, Histone Deacetylase; HO-1, Heme Oxygenase 1; HSP, Heat Shock Protei
Chlorogenic acid suppresses monocrotaline-induced sinusoidal obstruction syndrome: The potential contribution of NFκB, Egr1, Nrf2, MAPKs and PI3K signals
Keywords: GCL، لیگاز سیتست گلوتامات; ALT/AST, alanine/aspartate aminotransferase; CGA, chlorogenic acid; Egr1, early growth response1; GCL, glutamate cysteine ligase; H&E, hematoxylin-eosin; HSCT, hematopoietic stem cell transplantation; HVOD, hepatic veno-occlusive obstruction; IκB, inhibit
Redox-dependent induction of antioxidant defenses by phenolic diterpenes confers stress tolerance in normal human skin fibroblasts: Insights on replicative senescence
Keywords: GCL، لیگاز سیتست گلوتامات; ARE, antioxidant response element; CA, carnosic acid; CPD, cumulative population doubling; CS, carnosol; FTH1, ferritin heavy chain; GCL, glutamate cysteine ligase; GSH, glutathione; GST-P1, glutathione S-transferase P1; H2O2, hydrogen peroxide; HO-1, hem
Immunolocalization of glutathione biosynthesis enzymes in Arabidopsis thaliana
Keywords: GCL، لیگاز سیتست گلوتامات; Chloroplast; Glutathione; Immunolocalization; Stroma; ArabidopsisBSA, bovine serum albumin; EDTA, ethylene diamine tetraacetic acid; GCL, glutamate cysteine ligase; GS, glutathione synthetase; RbcL, ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco
Existing and potential therapeutic uses for N-acetylcysteine: The need for conversion to intracellular glutathione for antioxidant benefits
Keywords: GCL، لیگاز سیتست گلوتامات; N-acetylcysteine; Glutathione; AntioxidantNAC, N-acetyl-l-cysteine; GSH, glutathione; GCL, glutamate cysteine ligase; ROS, reactive oxygen species; GSSG, glutathione disulfide; GSH Px, glutathione peroxidises; COPD, chronic obstructive pulmonary disease;
Competition of nuclear factor-erythroid 2 factors related transcription factor isoforms, Nrf1 and Nrf2, in antioxidant enzyme induction
Keywords: GCL، لیگاز سیتست گلوتامات; EpRE, electrophile response element; ER, endoplasmic reticulum; GCL, glutamate cysteine ligase; GCLC, catalytic subunit of GCL; GCLM, modifier subunit of GCL; HBE1, human bronchial epithelial cells; HO-1, heme oxygenase; Nrf1, nuclear factor-erythroid 2 p
Characterization of global metabolic responses of glucose-6-phosphate dehydrogenase-deficient hepatoma cells to diamide-induced oxidative stress
Keywords: GCL، لیگاز سیتست گلوتامات; AMPK, AMP-activated protein kinase; Dox, Doxycycline; G6PD, Glucose-6-phosphate dehydrogenase; GCL, Glutamate cysteine ligase; Gi, shRNA against G6PD; GS, glutathione synthetase; GSH, Glutathione; GSR, Glutathione reductase; GSSG, Glutathione disulfide; L
An investigation of modifying effects of single nucleotide polymorphisms in metabolism-related genes on the relationship between peripheral nerve function and mercury levels in urine and hair
Keywords: GCL، لیگاز سیتست گلوتامات; CEPH, Centre d'Etude du Polymorphisme Humain; CMT, Charcot–Marie–Tooth; CTS, Carpel Tunnel Syndrome; DMA, Direct Mercury Analyzer; GCL, glutamate cysteine ligase; GPX, glutathione peroxidase; GSR, glutathione reductase; GSS, glutathione synthetase; GST, g
The role of glutathione in brain tumor drug resistance
Keywords: GCL، لیگاز سیتست گلوتامات; GSH, glutathione; GCL, glutamate cysteine ligase; GS, glutathione synthetase; GPx, glutathione peroxidase; GR, glutathione reductase; GST, glutathione-S-transferase; ROS, reactive oxygen species; Mrp, multidrug resistance-associated protein; γ-GC, γ-gluta
The redox stress hypothesis of aging
Keywords: GCL، لیگاز سیتست گلوتامات; ETC, electron transport chain; GCL, glutamate cysteine ligase; GSH, reduced glutathione; GSSG, oxidized glutathione; G6PD, glucose-6-phosphate dehydrogenase; HNE, 4-hydroxy-2-trans-nonenal; 8-OHdG, 8-hydroxydeoxyguanosine; MDA, malondialdehyde; MLS, maxim
Dietary green tea extract increases phase 2 enzyme activities in protecting against myocardial ischemia-reperfusion
Keywords: GCL، لیگاز سیتست گلوتامات; DCIP, 2,6-dichloroindophenol; GCL, glutamate cysteine ligase; GSH, reduced glutathione; GSSG, oxidized glutathione; IR, ischemia-reperfusion; LDH, lactate dehydrogenase; PMSF, phenylmethylsulfonyl fluoride; QR, quinone reductase; TBARS, thiobarbituric aci
The protective effects of Acanthopanax senticosus Harms aqueous extracts against oxidative stress: Role of Nrf2 and antioxidant enzymes
Keywords: GCL، لیگاز سیتست گلوتامات; ROS, reactive oxygen species; AS, Acanthopanax senticosus Harms; ASE, AS aqueous extracts; t-BHP, tert-butyl hydroperoxide; GSH, glutathione; GSSG, glutathione (oxidized form); CAT, catalase; GPx, glutathione peroxidase; GCL, glutamate cysteine ligase; GC
Induction of Nrf2-mediated cellular defenses and alteration of phase I activities as mechanisms of chemoprotective effects of coffee in the liver
Keywords: GCL، لیگاز سیتست گلوتامات; AFB1, aflatoxin B1; AFBO, AFB1-8,9-epoxide; Nrf2, nuclear factor-erythroid 2 p45-related factor 2; C+K, cafestol and kahweol; GCL, Glutamate cysteine Ligase; GSH, Reduced glutathione; GST, Glutathione S-transferase; HO-1, Heme oxygenase 1; NQO, NAD(P)H:qu
Reduced glutathione levels and expression of the enzymes of glutathione synthesis in cryopreserved hepatocyte monolayer cultures
Keywords: GCL، لیگاز سیتست گلوتامات; GSH, Reduced glutathione; GCL, glutamate cysteine ligase; GS, glutathione synthetase; CDNB, 1-chloro-2,4-dinitrobenzene; FCS, foetal calf serum; DMSO, dimethylsulfoxide; CFDA, carboxyfluorescein diacetate; CLSM, confocal laser scanning microscopyCryoprese
Thyroid hormone promotes glutathione synthesis in astrocytes by up regulation of glutamate cysteine ligase through differential stimulation of its catalytic and modulator subunit mRNAs
Keywords: GCL، لیگاز سیتست گلوتامات; TH, thyroid hormone; GSH, glutathione; γ-GCS, gamma-glutamyl cysteine synthetase; GCL, glutamate cysteine ligase; GCLC, catalytic subunit of GCL; GCLM, modulator subunit of GCL; γ-GT, γ-glutamyl transpeptidase; ROS, reactive oxygen species; ATP, adenosine
Glutathione protects cells against arsenite-induced toxicity
Keywords: GCL، لیگاز سیتست گلوتامات; BSO, DL-buthionine-(R,S)-sulfoximine; Cdk-4, cyclin-dependent kinase-4; Gcl, glutamate cysteine ligase; GSH, glutathione; Hsp90, heat shock protein 90; MDA, malondialdehyde; MTT, 3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; NAC, N-acetyl
Modulation of pregnane X receptor-and electrophile responsive element-mediated gene expression by dietary polyphenolic compounds
Keywords: GCL، لیگاز سیتست گلوتامات; CYPs, cytochrome P450-dependent monooxygenases; EpRE, electrophile responsive element; FCS, fetal calf serum; GCL, glutamate cysteine ligase; GI-GPx, gastrointestinal glutathione peroxidase; HO-1, heme oxygenase-1; PXR, pregnane X receptor; MTT, 3-[4,5-di
Effects of 6-hydroxydopamine on mitochondrial function and glutathione status in SH-SY5Y human neuroblastoma cells
Keywords: GCL، لیگاز سیتست گلوتامات; CCCP, carbonylcyanide-m-chlorophenylhydrazone; DMEM, Dulbecco's minimum essential medium; GCL, glutamate cysteine ligase; GCLC, glutamate cysteine ligase catalytic subunit; GCLM, glutamate cysteine ligase modifier subunit; GPX, glutathione peroxidase; G