Keywords: Bioorthogonal labeling; Farnesylation; Fluorescent isoprenoids; Geranylgeranylation; Prenylomics; Protein prenylation; Proteomics
مقالات ISI (ترجمه نشده)
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Keywords: Geranylgeranylation; Aryl-modified GGPP analogs; GGTase-I; Post-translational modification; Protein prenylation
Production of authentic geranylgeranylated KRAS4b using an engineered baculovirus system
Keywords: Prenylation; RAS; Geranylgeranylation; Protein production; Baculovirus; FNT; farnesyltransferase; GGTase; geranylgeranyltransferase; MBP; maltose-binding protein; FMe; farnesylated and methylated; GGMe; geranylgeranylated and methylated; GG; geranylgerany
Inhibition of the mevalonate pathway by simvastatin interferes with mast cell degranulation by disrupting the interaction between Rab27a and double C2 alpha proteins
Keywords: Simvastatin; Mast cells; Geranylgeranylation; Exocytosis protein; Rab27a; Proximity ligation assay;
Role of the C-terminal basic amino acids and the lipid anchor of the Gγ2 protein in membrane interactions and cell localization
Keywords: G protein; Electrostatic interactions; Geranylgeranylation; Carboxyl methylation; Posttranslational modifications;
Exploration of GGTase-I substrate requirements. Part 2: Synthesis and biochemical analysis of novel saturated geranylgeranyl diphosphate analogs
Keywords: Protein prenylation; Saturated GGPP analogs; Farnesylation; Geranylgeranylation; Isoprenoid synthesis
Alendronate prevents angiotensin II-induced collagen I production through geranylgeranylation-dependent RhoA/Rho kinase activation in cardiac fibroblasts
Keywords: Alendronate; Collagen I; Geranylgeranylation; RhoA; Rho kinaseALN, alendronate; Ang II, angiotensin II; ANOVA, a one-way analysis of variance; CF, cardiac fibroblast; DMAPP, dimethylallyl pyrophosphate; DMEM, Dulbecco's modified Eagle's medium; ECM, extra
Non-prenylatable, cytosolic Rac1 alters neurite outgrowth while retaining the ability to be activated
Keywords: Geranylgeranylation; Neurite outgrowth; Prenylation; Rho GTPases; Statins; Subcellular localization;
Synthesis and characterization of novel phosphonocarboxylate inhibitors of RGGT
Keywords: Phosphonocarboxylates; Bisphosphonates; Geranylgeranylation; RGGT; GGPPSPC, phosphonocarboxylate; BP, bisphosphonate; RGGT, Rab geranylgeranyl transferase, Rab GGTase, GGTase 2; TAG tunnel, a tunnel adjacent to GGPP binding site in RGGT; FTase, farnesyl t
Cloning, expression and characterization of an insect geranylgeranyl diphosphate synthase from Choristoneura fumiferana
Keywords: Geranylgeranyl diphosphate synthase; Substrate inhibition; Product inhibition; Homology modeling; Protein prenylation; Geranylgeranylation;
Synthesis and screening of a CaaL peptide library versus FTase reveals a surprising number of substrates
Keywords: Farnesylation; Geranylgeranylation; Peptide synthesis; Enzymes; Post-translational modification
Protein geranylgeranylation controls collagenase expression in osteoarthritic cartilage
Keywords: Statin; Simvastatin; Geranylgeranylation; Chondrocyte; Collagenase; MMP-13
Fluvastatin inhibits mast cell degranulation without changing the cytoplasmic Ca2+ level
Keywords: Mast cell; Statin; Fluvastatin; Degranulation; Geranylgeranylation; Cytosolic Ca2+
Inhibition of farnesylpyrophosphate synthase prevents angiotensin II-induced hypertrophic responses in rat neonatal cardiomyocytes: Involvement of the RhoA/Rho kinase pathway
Keywords: Farnesylpyrophosphate synthase; Angiotensin II; Cardiomyocytes; RhoA; Geranylgeranylation
Synthesis and evaluation of 3- and 7-substituted geranylgeranyl pyrophosphate analogs
Keywords: Geranylgeranylation; Isoprenoids; Palladium-catalyzed coupling; Post-translational modification;
Mevalonate sensitizes the nociceptive transmission in the mouse spinal cord
Keywords: RhoA; Spinal cord; Antinociception; Geranylgeranylation; Mevalonate; Translocation;
Mono- and dialkyl isoprenoid bisphosphonates as geranylgeranyl diphosphate synthase inhibitors
Keywords: Bisphosphonate; Geranylgeranyl diphosphate; Geranylgeranyl diphosphate synthase; Ras; Rap1a; Prenylation; Geranylgeranylation; Farnesyl diphosphate; Farnesylation
Geranylgeranylacetone inhibits ovarian cancer progression in vitro and in vivo
Keywords: LPA, lysophosphatidic acid; GGA, geranylgeranylacetone; GGOH, geranylgeraniol; FOH, farnesol; ROCK, Rho-associated kinaseGeranylgeranylacetone; Lysophosphatidic acid; Rho; Ras; Geranylgeranylation; Ovarian cancer
Alendronate suppresses tumor angiogenesis by inhibiting Rho activation of endothelial cells
Keywords: Alendronate; Angiogenesis; Rho; Geranylgeranylation; Bisphosphonate; Endothelial cell; Ovarian cancer;
Lovastatin suppresses erythropoietin receptor surface expression through dual inhibition of glycosylation and geranylgeranylation
Keywords: Erythropoietin; Erythropoietin receptor; Lovastatin; Geranylgeranylation; Glycosylation; GGPP
Simvastatin potentiates tumor necrosis factor α-mediated apoptosis of human vascular endothelial cells via the inhibition of the geranylgeranylation of RhoA
Keywords: Statins; Apoptosis; RhoA; Geranylgeranylation; Anti-tumor effects;
Inhibitory effects of mevastatin and a geranylgeranyl transferase I inhibitor (GGTI-2166) on mononuclear osteoclast formation induced by receptor activator of NFκB ligand (RANKL) or tumor necrosis factor-α (TNF-α)
Keywords: pOC; preosteoclast; RANKL; receptor activator of NFκB ligand; M-CSF; macrophage colony-stimulating factor; GGTI; geranylgeranyl transferase inhibitor; GGOH; geranylgeraniol; FTI; farnesyl transferase inhibitor; TRAP; tartrate-resistant acid phosphatase;