Keywords: سمیت گلوتاتیک; Glucotoxicity; Beta cell; Histone acetylation; Histone acetyltransferase p300; Histone deacetylase; Thioredoxin-interacting protein;
مقالات ISI سمیت گلوتاتیک (ترجمه نشده)
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Keywords: سمیت گلوتاتیک; Emodin; Diabetes; CCL5; Glucotoxicity; Endothelium; InflammationEmodin (PubChem CID: 3220); Glucose (PubChem CID: 5973)
Keywords: سمیت گلوتاتیک; Islets; Beta-cells; Cytokines; Calcium; Insulin; Low-grade inflammation; Diabetes; Chronic; Free fatty acid; Palmitate; Oleate; Linoleate; Glucotoxicity; High glucose; Endoplasmic reticulum; Thapsigargin; Unfolded protein response; ER stress; Oxidative st
Keywords: سمیت گلوتاتیک; Type 2 diabetes; Feline diabetes; Glucotoxicity; Inflammation; Pancreas;
Keywords: سمیت گلوتاتیک; Metabolomics; Glucotoxicity; Insulin secretion;
Protective effects of (-)-epicatechin and the colonic metabolite 3,4-dihydroxyphenylacetic acid against glucotoxicity-induced insulin signalling blockade and altered glucose uptake and production in renal tubular NRK-52E cells
Keywords: سمیت گلوتاتیک; Colonic-derived flavonoid metabolites; Epicatechin; Glucose homeostasis; Glucotoxicity; Insulin signalling pathway; NRK-52E cells; AKT/PKB; protein kinase B; AMPK; 5â²-AMP-activated protein kinase; DHBA; 2,3-dihydroxybenzoic acid; DHPAA; 3,4-dihydroxyphe
The impairment of glucose-stimulated insulin secretion in pancreatic β-cells caused by prolonged glucotoxicity and lipotoxicity is associated with elevated adaptive antioxidant response
Keywords: سمیت گلوتاتیک; Adaptive antioxidant response; Pancreatic β-cells; Glucotoxicity; Lipotoxicity; Glucose-stimulated insulin secretion;
Upregulation of UCP2 in beta-cells confers partial protection against both oxidative stress and glucotoxicity
Keywords: سمیت گلوتاتیک; Glucotoxicity; Oxidative stress; UCP2; Insulin secretion; Beta-cell; Pancreatic islet;
Geniposide improves insulin production and reduces apoptosis in high glucose-induced glucotoxic insulinoma cells
Keywords: سمیت گلوتاتیک; Glucotoxicity; Glucose-stimulated insulin secretion; Apoptosis; Geniposide;
Disrupted dynamics of F-actin and insulin granule fusion in INS-1 832/13 beta-cells exposed to glucotoxicity: partial restoration by glucagon-like peptide 1
Keywords: سمیت گلوتاتیک; C; Control; EGFP; Enhanced Green Fluorescent protein; ESI-05; 4-Methylphenyl-2, 4, 6-trimethylphenylsulfone; F-actin; Filamentous Actin; GLP-1; Glucagon-like peptide 1; GSIS; Glucose-stimulated insulin secretion; HG; High-glucose; NPY; Neuropeptide Y; RFP
Effects of Trans-Resveratrol on hyperglycemia-induced abnormal spermatogenesis, DNA damage and alterations in poly (ADP-ribose) polymerase signaling in rat testis
Keywords: سمیت گلوتاتیک; Cell survival; DNA damage; Germ cell toxicity; Glucotoxicity; Oxidative stress; Parthanatos; Type 1 diabetes mellitus;
Beta-cell mitochondrial carriers and the diabetogenic stress response
Keywords: سمیت گلوتاتیک; Pancreatic islet; Beta-cell; Mitochondria; Diabetes; Glucotoxicity;
Short-term selective alleviation of glucotoxicity and lipotoxicity ameliorates the suppressed expression of key β-cell factors under diabetic conditions
Keywords: سمیت گلوتاتیک; Glucotoxicity; Lipotoxicity; SGLT2 inhibitor; Fibrate; islet β-cell dysfunction; Insulin transcription factors;
Differential molecular and cellular responses of GLP-1 secreting L-cells and pancreatic alpha cells to glucotoxicity and lipotoxicity
Keywords: سمیت گلوتاتیک; Glucotoxicity; Lipotoxicity; GLP-1; L cells; Alpha cells; Beta cells;
Metabolic effects of SGLT-2 inhibitors beyond increased glucosuria: A review of the clinical evidence
Keywords: سمیت گلوتاتیک; Canagliflozin; Dapagliflozin; Empagliflozin; Energy balance; Glucotoxicity; Insulin secretion; Insulin sensitivity; Type 2 diabetes
Prevention by metformin of alterations induced by chronic exposure to high glucose in human islet beta cells is associated with preserved ATP/ADP ratio
Keywords: سمیت گلوتاتیک; Beta cells; Metformin; Insulin secretion; Glucotoxicity; Diabetes; Adenine nucleotides;
Estrogen reduces endoplasmic reticulum stress to protect against glucotoxicity induced-pancreatic β-cell death
Keywords: سمیت گلوتاتیک; ER; endoplasmic reticulum; UPR; unfolded protein response; GRP-78; glucose-regulated protein 78; CHOP; CCAAT/enhancer-binding protein homologous protein; PI; propidium iodide; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide thiazolyl bl
Glucagon-like peptide 1 potentiates glucotoxicity-diminished insulin secretion via stimulation of cAMP-PKA signaling in INS-1E cells and mouse islets
Keywords: سمیت گلوتاتیک; GLP-1; Glucotoxicity; Insulin secretion; cAMP; PKA;
Alternanthera paronychioides protects pancreatic β-cells from glucotoxicity by its antioxidant, antiapoptotic and insulin secretagogue actions
Keywords: سمیت گلوتاتیک; MEAP; methanol extracts from Alternanthera paronychioides; EEAP; ethanol extracts from Alternanthera paronychioides; WEAP; water extracts from Alternanthera paronychioides; TEAC; Trolox equivalent antioxidant capacity; ORAC; oxygen radical absorbance capa
Glucotoxic conditions induce endoplasmic reticulum stress to cause caspase 3 mediated lamin B degradation in pancreatic β-cells: Protection by nifedipine
Keywords: سمیت گلوتاتیک; CHOP; C/EBP homologous protein; ER; endoplasmic reticulum; FTase; farnesyl transferase; FTI; farnesyl transferase inhibitor; Nif; nifedipine; PBA; 4-phenylbutyric acid; Tg; thapsigargin; Caspase 3; Glucotoxicity; Nuclear lamin B; Pancreatic islet β-cell;
Recomendaciones para el empleo de antidiabéticos orales en la diabetes tipo 2
Keywords: سمیت گلوتاتیک; Cambios en el estilo de vida; Glucotoxicidad; Lipotoxicidad; MonoterapiaLifestyle changes; Glucotoxicity; Lipotoxicity; Single-therapy
Inhibition of fatty acid translocase cluster determinant 36 (CD36), stimulated by hyperglycemia, prevents glucotoxicity in INS-1 cells
Keywords: سمیت گلوتاتیک; CD36; Glucotoxicity; Insulin secretion; INS-1 cells;
Gossypin, a flavonol glucoside protects pancreatic beta-cells from glucotoxicity in streptozotocin-induced experimental diabetes in rats
Keywords: سمیت گلوتاتیک; Gossypin; Flavonoid; Streptozotocin; Pancreatic beta-cells; Glucotoxicity
Protein O-linked β-N-acetylglucosamine: A novel effector of cardiomyocyte metabolism and function
Keywords: سمیت گلوتاتیک; O-GlcNAc; Glucotoxicity; Cardiac metabolism; Cardioprotection; Reactive oxygen species;
Cyanide preconditioning protects brain endothelial and NT2 neuron-like cells against glucotoxicity: Role of mitochondrial reactive oxygen species and HIF-1α
Keywords: سمیت گلوتاتیک; Cyanide; Glucotoxicity; Hypoxia inducible factor-1α; Mitochondria; Mitochondrial network; Preconditioning; Mitochondrial reactive oxygen species;
Cellular and molecular mechanisms of vascular injury in diabetes — Part II: Cellular mechanisms and therapeutic targets
Keywords: سمیت گلوتاتیک; Diabetes; Hyperglycemia; Glucotoxicity; Insulin resistance; Vascular damage; Endothelial progenitor cells; Atherosclerosis
Cellular and molecular mechanisms of vascular injury in diabetes — Part I: Pathways of vascular disease in diabetes
Keywords: سمیت گلوتاتیک; Diabetes; Hyperglycemia; Glucotoxicity; Insulin resistance; Vascular damage; Atherosclerosis
Incretin secretion is not restored by short-term strict glycaemic control in Korean hyperglycaemic patients with type 2 diabetes
Keywords: سمیت گلوتاتیک; Glucotoxicity; Glycaemic control; Incretin secretion; Insulin resistance; Type 2 diabetes;
The effect of chromium on rat insulinoma cells in high glucose conditions
Keywords: سمیت گلوتاتیک; Chromium chloride; Diabetes; INS-1 cell; Protection; Glucotoxicity
Antioxidant protection of Malaysian tualang honey in pancreas of normal and streptozotocin-induced diabetic rats
Keywords: سمیت گلوتاتیک; Stress oxydatif; Diabète sucré; Glucotoxicité; Streptozotocine; Miel Tualang; PancréasOxidative stress; Diabetes mellitus; Glucotoxicity; Streptozotocin; Tualang honey; Pancreas
O-GlcNAc modification, insulin signaling and diabetic complications
Keywords: سمیت گلوتاتیک; O-GlcNAcylation; Post-translational modifications; Insulin signaling; Insulin resistance; Glucotoxicity; Diabetic complications; ReviewO-GlcNAcylation; Modifications post-traductionnelles; Signalisation de l’insuline; Résistance à l’insuline; Glucotoxicit
Dynamin-related protein 1 mediates high glucose induced pancreatic beta cell apoptosis
Keywords: سمیت گلوتاتیک; Dynamin-related protein-1; Mitochondrial fission; Beta cell dysfunction; Apoptosis; Glucotoxicity;
Glucose toxicity: The leading actor in the pathogenesis and clinical history of type 2 diabetes – mechanisms and potentials for treatment
Keywords: سمیت گلوتاتیک; Glucose toxicity; Glucotoxicity; Lipotoxicity; Insulin resistance; Beta cell; Diabetes pathogenesis; Diabetes treatment; Hexosamine; Oxidative stress
The GK rat beta-cell: A prototype for the diseased human beta-cell in type 2 diabetes?
Keywords: سمیت گلوتاتیک; Type 2 diabetes; GK rat; Beta-cell; Development; Neogenesis; Glucotoxicity; Inflammation; Oxidative stress; Insulin secretion; Metabolic programming; Genetic; Epigenetic
O-GlcNAc modification of FoxO1 increases its transcriptional activity: A role in the glucotoxicity phenomenon?
Keywords: سمیت گلوتاتیک; O-Glycosylation; Glucose 6-phosphatase; PGC1; Glucotoxicity; DiabetesBADGP, benzyl-2-acetamido-2-deoxy-α-d-galactopyranoside; CBP, CREB binding protein; DON, 6-diazo-5-oxo-norleucine; FoxO1, Forkhead Box Other-1; G6Pase, glucose 6-phosphatase; GlcN, gluco
Involvement of chronic stresses in rat islet and INS-1 cell glucotoxicity induced by intermittent high glucose
Keywords: سمیت گلوتاتیک; Endoplasmic reticulum stress; Oxidative stress; Intermittent high glucose; Glucotoxicity; Rat pancreatic islet; INS-1 cell
Protection of pancreatic beta-cells: Is it feasible?
Keywords: سمیت گلوتاتیک; Type 2 diabetes; Beta-cell; Glucotoxicity; Lipotoxicity; Inflammation; Oxidant stress; Apoptosis; Metabolic control
Mitochondrial Ca2+, the secret behind the function of uncoupling proteins 2 and 3?
Keywords: سمیت گلوتاتیک; Ca2+ signaling; Diabetes; Fatty acid transport; Glucotoxicity; Lipid metabolism; Lipotoxicity; Mitochondria; Mitochondrial Ca2+ uniporter; Insulin secretion; Uncoupling proteins; UCP2; UCP3; ROS
In vitro evidence of glucose-induced toxicity in GnRH secreting neurons: high glucose concentrations influence GnRH secretion, impair cell viability, and induce apoptosis in the GT1-1 neuronal cell line
Keywords: سمیت گلوتاتیک; Apoptosis; GnRH; GT1; neuron; glucotoxicity; in vitro
The pancreatic beta-cell in human Type 2 diabetes
Keywords: سمیت گلوتاتیک; Beta-cell; Type 2 diabetes; Glucotoxicity; Lipotoxicity; Insulin secretion
Comparison of type 1, type 2, and atypical ketosis-prone diabetes at 4 years of diabetes duration
Keywords: سمیت گلوتاتیک; Diabetic ketoacidosis; Glucotoxicity; Hyperglycemic crisis; Insulin resistance; Insulin secretion; Ketosis
Diabetes, glucose toxicity, and oxidative stress: A case of double jeopardy for the pancreatic islet β cell
Keywords: سمیت گلوتاتیک; Diabetes; Glucotoxicity; Oxidative stress; Pancreatic islet β cell; MafA; PDX-1; Insulin gene expression; Free radicals
Mechanisms of insulin resistance caused by nutrient toxicity
Keywords: سمیت گلوتاتیک; Lipotoxicity; Glucotoxicity; Protein kinase C; Hexosamine biosynthesis pathway; Cytokines;
Early use of insulin in type 2 diabetes
Keywords: سمیت گلوتاتیک; Early insulin treatment; Diabetes mellitus type 2; Glucotoxicity; Hypoglycemia;