Pathogenic Mutations in the Hydrophobic Core of the Human Prion Protein Can Promote Structural Instability and Misfolding
Keywords: PrP, prion protein; recPrP, recombinant prion protein; CJD, Creutzfeldt-Jakob disease; GPI, glycosylphosphatidyl-inositol; MD, molecular dynamics; WT, wild type; Cα RMSD, root-mean-square deviation of Cα atom coordinates from the starting structure; Cα RM