Novel multiple opioid ligands based on 4-aminobenzazepinone (Aba), azepinoindole (Aia) and tetrahydroisoquinoline (Tic) scaffolds
Keywords: Aba, 4-amino-1,2,4,5-tetrahydro-2-benzazepin-3-one; Aia, 3-amino-indolo[2,3-c]azepin-2-one; CM, cross metathesis; DML, designed multiple ligand; Dmt, 2′,6′-dimethyl-l-tyrosine; DOR, δ-opioid receptor; GPI, guinea-pig ileum; [35S]GTPγS, [35S]guanosine-5′-O