
Keywords: Terpene fold; Trichodiene synthase; Catalytic site evolution; Single domain proteins; Multi-domain proteins; EAS; 5-epi-aristolochene synthase; PS; Pentalenene synthase; EIZS; Epi-isozizaene synthase; CS; 1,8-cineole synthase; DMAPP; Dimethylallyl diphosp