Nalfurafine is a G-protein biased agonist having significantly greater bias at the human than rodent form of the kappa opioid receptor
Keywords: Kappa opioid receptor; Biased signaling; p38 MAPK; Dysphoria; ERK1/2; extracellular signal-regulated kinase; GRK3; G protein-coupled receptor kinase 3; hKOR; human kappa opioid receptor; MAPK; mitogen activated protein kinase; norBNI; norbinaltorphimine;