Keywords: GWAS، مطالعات ارتباطی گسترده در ژنوم; TCGA, The Cancer Genome Atlas; GWAS, genome-wide association studies; eQTL, expression quantitative trait loci; SNP, single nucleotide polymorphism; MAF, minor allele frequency; HWE, Hardy–Weinberg equilibrium; LD, linkage disequilibrium; CI, confidence i
مقالات ISI GWAS، مطالعات ارتباطی گسترده در ژنوم (ترجمه نشده)
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Keywords: GWAS، مطالعات ارتباطی گسترده در ژنوم; Allergy; Angiogenesis; Corticosteroid; Endothelial cells; InflammationAD, atopic dermatitis; BA, bronchial asthma; CCR, CC chemokine receptor; COPD, chronic obstructive pulmonary disease; GWAS, genome-wide association studies; ICAM, intercellular adhesion
Keywords: GWAS، مطالعات ارتباطی گسترده در ژنوم; DNA, deoxyribonucleic acid; RNA, ribonucleic acid; PCOS, polycystic ovarian syndrome; GWAS, genome-wide association studies; OMIM, Online Mendelian Inheritance in ManHuman reproduction and related infertility genes; Genetic pathways; Meiosis; Steroidogene
Keywords: GWAS، مطالعات ارتباطی گسترده در ژنوم; CAD, coronary artery disease; GWAS, genome-wide association studies; GRS, genetic risk score; Oregon-SUDS, Oregon-Sudden Unexpected Death Study; SCD, sudden cardiac death; WTCCC, Wellcome Trust Case–Control ConsortiumSudden cardiac death; Coronary artery
Keywords: GWAS، مطالعات ارتباطی گسترده در ژنوم; ACSL1, Acyl-CoA synthetase long-chain family member 1; CREB1, cAMP responsive element binding protein 1; CHD, Coronary heart disease; CRF, Cardiorespiratory fitness; CVD, Cardiovascular disease; GWAS, Genome-wide association studies; FMD, Flow-mediated di
Keywords: GWAS، مطالعات ارتباطی گسترده در ژنوم; COGA, collaborative study on the genetics of alcoholism; DNA, deoxyribonucleic acid; FDA, Food and Drug Administration; GWAS, genome-wide association studies; mRNA, messenger ribonucleic acid; SAGE, study of addiction: genetics and environment; SNPs, sing
Keywords: GWAS، مطالعات ارتباطی گسترده در ژنوم; SNP, single nucleotide polymorphisms; CS, consomic strain; Chr, chromosome; GWAS, genome-wide association studies; QTL, quantitative trait loci; MGI, mouse genome informatics; TAC, transversal aortic constriction; IVS, intraventricular septum; LVID, left
Keywords: GWAS، مطالعات ارتباطی گسترده در ژنوم; HE, HumanExome array; HOEE, HumanOmniExpressExome array; HOE, HumanOmniExpressGWAS array; GWAS, genome-wide association studies; SNPs, single nucleotide polymorphisms; MRS, the Marine Resiliency Study; PTSD, post-traumatic stress disorder; OEF/OIF, Operat
Keywords: GWAS، مطالعات ارتباطی گسترده در ژنوم; Diet; Genes; Genetics; Lipids; NutritionACS, acute coronary syndrome; CAD, coronary artery disease; CI, confidence interval; CVD, cardiovascular diseases; DHA, docosahexaenoic acid; EPA, eicosapentaenoic acid; GWAS, genome-wide association studies; HWE, H
Keywords: GWAS، مطالعات ارتباطی گسترده در ژنوم; CD, Crohn's disease; DC, dendritic cell; GWAS, genome-wide association studies; IBD, inflammatory bowel disease; IFN, interferon; IL, interleukin; ILC, innate lymphoid cell; iNKT, invariant natural killer T; MyD88, myeloid differentiation primary response
Keywords: GWAS، مطالعات ارتباطی گسترده در ژنوم; Genetics; Insulin resistance; Insulin signalling; PTEN; Skeletal muscleAkt, v-akt murine thymoma viral oncogene homologue; FFM, fat-free mass; GWAS, genome-wide association studies; HGP, hepatic glucose production rate; IRS-1-PI3K, insulin receptor substr
Impacts of common variants in ALDH2 on coronary artery disease patients
Keywords: GWAS، مطالعات ارتباطی گسترده در ژنوم; GWAS, genome-wide association studies; ALDH2, aldehyde dehydrogenase 2; CAD, coronary artery disease; 4-HNE, 4-hydroxy-2-nonenal; MAF, minor allele frequency; HWE, Hardy Weinberg equilibriumALDH2; Common variant; Coronary artery disease; Outcome
Prospective study of γ′ fibrinogen and incident venous thromboembolism: The Longitudinal Investigation of Thromboembolism Etiology (LITE)
Keywords: GWAS، مطالعات ارتباطی گسترده در ژنوم; ARIC, Atherosclerosis Risk in Communities; BMI, body mass index; CHS, Cardiovascular Health Study; DVT, deep vein thrombosis; ELISA, enzyme-linked immunosorbent assay; FGG, fibrinogen gamma chain gene; GWAS, genome-wide association studies; HR, hazard rat
Identifying microRNAs related to Alzheimer's disease from differential methylation signatures
Keywords: GWAS، مطالعات ارتباطی گسترده در ژنوم; miRNA, microRNA; AD, Alzheimer's disease; RISC, RNA induced silencing complex; CNS, central nervous system; SP, senile plaques; Aß, amyloid-beta; NFT, neurofibrillary tangles; GWAS, genome-wide association studies; EWAS, epigenome-wide association studies
Treating psoriasis by targeting its susceptibility gene Rel
Keywords: GWAS، مطالعات ارتباطی گسترده در ژنوم; c-Rel; Psoriasis; IL-17A; siRNA; PEG-PLL-PLLeu micellesIMQ, imiquimod; siRel, c-Rel siRNA; siNC, negative control siRNA; GWAS, genome-wide association studies; NBD, nemo-binding domain; BMDC, bone marrow-derived dendritic cells; BMDM, bone marrow-derived
A Pleiotropic Missense Variant in SLC39A8 Is Associated With Crohn’s Disease and Human Gut Microbiome Composition
Keywords: GWAS، مطالعات ارتباطی گسترده در ژنوم; Genetics; Inflammatory Bowel Diseases; MicrobiotaAla, alanine; BMI, body mass index; CD, Crohn's disease; CI, confidence intervals; GWAS, genome-wide association studies; IBD, inflammatory bowel disease; LD, linkage disequilibrium; OR, odds ratio; OTU, op
PNPLA3 gene in liver diseases
Keywords: GWAS، مطالعات ارتباطی گسترده در ژنوم; GWAS, genome-wide association studies; CHC, chronic hepatitis C; SNP, single nucleotide polymorphism; HCV, hepatitis C virus; PNPLA3, patatin-like phospholipase domain containing 3; NAFLD, nonalcoholic fatty liver disease; ALT, alanine aminotransferase; B
Epigenetic regulation of G protein coupled receptor signaling and its implications in psychiatric disorders
Keywords: GWAS، مطالعات ارتباطی گسترده در ژنوم; GPCRs, Gprotein-coupled receptors; HDAC, histone deacetylase; CNS, central nervous system; GWAS, genome-wide association studies; GEFs, guanine nucleotide exchange factors; GDP, guanosine diphosphate; GTP, guanosine triphosphate; WHO, world health organiz
CYP2C8 rs17110453 and EPHX2 rs751141 two-locus interaction increases susceptibility to ischemic stroke
Keywords: GWAS، مطالعات ارتباطی گسترده در ژنوم; IS, ischemic stroke; CYP, cytochrome P450; GMDR, generalized multifactor dimensionality reduction; AA, arachidonic acid; GWAS, genome-wide association studies; EETs, epoxygenases into four epoxyeicosatrienoic acids; sEH, soluble epoxide hydrolase; EPHX2,
Synergistic combined effect between CD40-1C > T and CTLA-4 + 6230G > A polymorphisms in Graves' disease
Keywords: GWAS، مطالعات ارتباطی گسترده در ژنوم; GD, Graves' disease; TRAb, thyroid stimulating hormone receptor antibodies; GWAS, genome-wide association studies; SNP, single nucleotide polymorphism; PCR-HRM, polymerase chain reaction-high resolution melting; TSH, thyroid stimulating hormone; FT3, free
Catalase C-262T polymorphism and risk of prostate cancer: Evidence from meta-analysis
Keywords: GWAS، مطالعات ارتباطی گسترده در ژنوم; CAT, catalase; PCa, prostate cancer; OR, odds ratios; CI, confidence intervals; GWAS, genome-wide association studies; MPO, myeloperoxidase; SOD2, superoxide dismutase; ROS, reactive oxygen speciesCatalase; Polymorphism; Prostate cancer; Meta-analysis
Post-Transcriptional Regulation of Renalase Gene by miR-29 and miR-146 MicroRNAs: Implications for Cardiometabolic Disorders
Keywords: GWAS، مطالعات ارتباطی گسترده در ژنوم; BPH, blood pressure high; BPL, blood pressure low; BPN, blood pressure normal; DBP, diastolic blood pressure; GWAS, genome-wide association studies; miRNA, microRNA; SBP, systolic blood pressure; SNP, single nucleotide polymorphismrenalase; microRNA; post
Combined effect between CHRNB3–CHRNA6 region gene variant (rs6474412) and smoking in psoriasis vulgaris severity
Keywords: GWAS، مطالعات ارتباطی گسترده در ژنوم; PV, psoriasis vulgaris; GWAS, genome-wide association studies; PASI, Psoriasis Area and Severity Index; IL13, interleukin-13; nAChR, nicotinic acetylcholine receptor; BMI, body mass index; WHO, World Health Organization; OR, odds ratios; CI, confidence in
Genetic predisposition to obesity and risk of subclinical atherosclerosis
Keywords: GWAS، مطالعات ارتباطی گسترده در ژنوم; BMI, body mass index; CAC, coronary artery calcification; CCA IMT, common carotid artery intima–media thickness; CVD, cardiovascular disease; DBP, diastolic blood pressure; GRS, genetic risk score; GWAS, genome-wide association studies; HDL-c, high-densit
IL10 polymorphisms associated with Behçet’s disease in Chinese Han
Keywords: GWAS، مطالعات ارتباطی گسترده در ژنوم; BD, Behçet’s disease; SLE, systemic lupus rythematosus; RA, rheumatoid arthritis; UC, ulcerative colitis; GWAS, genome-wide association studies; SNP, single nucleotide polymorphism; LD, linkage disequilibrium
Impact of IL28B on the treatment decision in naïve and experienced patients with genotype 1 and 4 chronic hepatitis C in real-life clinical practice: A prospective multicenter cohort
Keywords: GWAS، مطالعات ارتباطی گسترده در ژنوم; GWAS, genome-wide association studies; Peg-IFN, pegylated-interferon; RBV, ribavirin; PR, peg-IFN and RBV; HCV, hepatitis C virus; G1, genotype 1; SVR, sustained virological response; DAAs, direct-acting antivirals; RVR, rapid viral response; CHC, chronic
Genetic variations in VDR associated with prostate cancer risk and progression in a Korean population
Keywords: GWAS، مطالعات ارتباطی گسترده در ژنوم; VDR, vitamin D receptor; SNP, single nucleotide polymorphism; GWAS, genome-wide association studies; PSA, prostate-specific antigen; BPH, benign prostate hyperplasia; TURP, transurethral resection of the prostate; MAF, minor allele frequency; LD, linkage
Association between DAOA gene polymorphisms and the risk of schizophrenia, bipolar disorder and depressive disorder
Keywords: GWAS، مطالعات ارتباطی گسترده در ژنوم; SCZ, schizophrenia; BD, bipolar disorder; DD, depressive disorder; DAOA, d-amino acid oxidase activator; Ors, odds ratios; CIs, confidence intervals; I2, the inconsistency index; SNPs, single nucleotide polymorphisms; GWAS, genome-wide association studies
Variants of NLRP3 gene are associated with insulin resistance in Chinese Han population with type-2 diabetes
Keywords: GWAS، مطالعات ارتباطی گسترده در ژنوم; NLRP3, nod like receptor pyrin domain containing 3; T2DM, type-2 diabetes; ASC, apoptosis-associated speck-like protein containing a caspase recruitment domain; IR, insulin resistance; GWAS, genome-wide association studies; HDL-C, HDL-cholesterol; LDL-C,
MAPT gene rs1052553 variant is not associated with the risk for multiple sclerosis
Keywords: GWAS، مطالعات ارتباطی گسترده در ژنوم; MS, multiple sclerosis; GWAS, genome-wide association studies; TNFRSF1A, tumor necrosis factor receptor superfamily member 1A; CSF, cerebrospinal fluid; TPPP/p25, tubulin polymerization promoting protein 25; MAPT, microtubule-associated protein tau; SNP,
Effect of a GFOD2 variant on responses in total and LDL cholesterol in Mexican subjects with hypercholesterolemia after soy protein and soluble fiber supplementation
Keywords: GWAS، مطالعات ارتباطی گسترده در ژنوم; ATP III, National Cholesterol Education Program Adult Treatment Panel III; DS, dietary supplementation; GFOD2, glucose-fructose oxidoreductase domain containing 2; GWAS, genome-wide association studies; HDL-C, high-density lipoprotein cholesterol; LDL-C,
Association between the ghrelin Leu72Met polymorphism and type 2 diabetes risk: A meta-analysis
Keywords: GWAS، مطالعات ارتباطی گسترده در ژنوم; AG, acylated ghrelin; BMI, body mass index; CI, confidence interval; GHSR-1a, growth hormone secretagogue receptor 1a; GOAT, ghrelin O-acyltransferase; GWAS, genome-wide association studies; HWE, Hardy–Weinberg equilibrium; IDF, international diabetes fed
Association of three polymorphisms in ARID5B, IKZF1and CEBPE with the risk of childhood acute lymphoblastic leukemia in a Chinese population
Keywords: GWAS، مطالعات ارتباطی گسترده در ژنوم; ALL, acute lymphoblastic leukemia; GWAS, genome-wide association studies; ARID5B, AT rich interactive domain 5B; IKZF1, Ikaros zinc finger 1; CEBPE, CCAAT/enhancer-binding protein ε; OR, odds ratio; CI, confidence interval; SAS, Statistical Analysis Syste
Potentially functional polymorphisms in ATG10 are associated with risk of breast cancer in a Chinese population
Keywords: GWAS، مطالعات ارتباطی گسترده در ژنوم; ATG, Autophagy-related genes; ER, Estrogen receptor; PR, Progesterone receptor; SNP, Single nucleotide polymorphism; ESEs, Exonic splicing enhancers; GWAS, Genome-wide association studies; OR, Odds ratios; CI, 95% confidence interval; LD, Linkage disequil
Association of HHIP polymorphisms with COPD and COPD-related phenotypes in a Chinese Han population
Keywords: GWAS، مطالعات ارتباطی گسترده در ژنوم; HHIP, hedgehog interacting protein; COPD, chronic obstructive pulmonary disease; GWAS, genome-wide association studies; SHH, sonic hedgehog; SNPs, single nucleotide polymorphisms; BMI, body mass index; FEV1, forced expiratory volume in 1 s; FVC, forced vi
Cardiovascular Disease, Psychosocial Factors, and Genetics: The Case of Depression
Keywords: GWAS، مطالعات ارتباطی گسترده در ژنوم; CFR, coronary flow reserve; CVD, cardiovascular disease; DZ, dizygotic; GWAS, genome-wide association studies; HRV, heart rate variability; IL-6, interleukin-6; MI, myocardial infarction; MZ, monozygoticDepression; Psychosocial risk factors; Genetics; Car
Gastric intrinsic factor deficiency with combined GIF heterozygous mutations and FUT2 secretor variant
Keywords: GWAS، مطالعات ارتباطی گسترده در ژنوم; FUT2; Gastric intrinsic factor; Inherited intrinsic factor deficiency; Vitamin B12; CobalaminCUBN, cubilin gene; GIF, gastric intrinsic factor; FUT2, fucosyltransferase 2; GWAS, genome-wide association studies; HC, Haptocorrin; H. pylori, Helicobacter pyl
Identification of susceptibility modules for coronary artery disease using a genome wide integrated network analysis
Keywords: GWAS، مطالعات ارتباطی گسترده در ژنوم; CAD, coronary artery disease; GWAS, genome-wide association studies; HuGE, The Phenopedia component of the online Human Genome Epidemiology; OR, odds ratio; PPI, protein–protein interaction; QC, quality control; SNP, single nucleotide polymorphism; WTCCC,
Exploration of deleterious single nucleotide polymorphisms in late-onset Alzheimer disease susceptibility genes
Keywords: GWAS، مطالعات ارتباطی گسترده در ژنوم; AD, Alzheimer disease; nsSNP, non-synonymous single nucleotide polymorphism; LOAD, late-onset Alzheimer disease; GWAS, genome-wide association studies; CLU, encoding clusterin; PICALM, encoding phosphatidylinositol binding clathrin assembly protein; CR1,
Etiology of myasthenia gravis: Innate immunity signature in pathological thymus
Keywords: GWAS، مطالعات ارتباطی گسترده در ژنوم; AChR, acetylcholine receptor; EAMG, experimental autoimmune MG; EBV, Epstein–Barr virus; ENOX1, ecto-NADH oxidase 1 gene; EOMG, early-onset MG; GC, germinal center; GWAS, genome-wide association studies; HLA, human leukocyte antigen; IFN, interferon; IL,
Mechanistic basis of immunotherapies for type 1 diabetes mellitus
Keywords: GWAS، مطالعات ارتباطی گسترده در ژنوم; Aire, autoimmune regulator; APC, antigen-presenting cell; ATG, antithymocyte globulin; CTLA-4, cytotoxic T-lymphocyte antigen 4; DCs, dendritic cells; FcR, Fc receptor; GAD65, glutamate decarboxylase 65; GWAS, genome-wide association studies; HLA, human l
Association Between the Chromosome 9p21 Locus and Angiographic Coronary Artery Disease Burden : A Collaborative Meta-Analysis
Keywords: GWAS، مطالعات ارتباطی گسترده در ژنوم; 9p21; angiography; coronary artery disease; meta-analysis; myocardial infarction; single nucleotide polymorphismCAD, coronary artery disease; CHD, coronary heart disease; CI, confidence interval; GWAS, genome-wide association studies; LD, linkage disequil
A case-control study provides evidence of association for a common SNP rs974819 in PDGFD to coronary heart disease and suggests a sex-dependent effect
Keywords: GWAS، مطالعات ارتباطی گسترده در ژنوم; SNP, Single nucleotide polymorphism; CHD, coronary heart disease; LIPA, lipase A; PDGFD, Platelet-derived growth factor D; HWE, Hardy–Weinberg equilibrium; GWAS, genome-wide association studies; MI, myocardial infarctionCoronary heart disease; SNP; LIPA;
From candidate gene to genome-wide association studies in cardiovascular disease
Keywords: GWAS، مطالعات ارتباطی گسترده در ژنوم; CAD, coronary artery disease; FDR, false discovery rate; GWAS, genome-wide association studies; MI, myocardial infarction; NCBI, National Center for Biotechnology Information; SNP, single nucleotide polymorphismcardiovascular diseases/genetics; genetic ep
Transcription factor-7-like 2 gene variants are strongly associated with type 2 diabetes in Lebanese subjects
Keywords: GWAS، مطالعات ارتباطی گسترده در ژنوم; GWAS, genome-wide association studies; LD, linkage disequilibrium; MAF, minor allele frequencies; SNP, single nucleotide polymorphism; T2DM, type 2 diabetesDiabetes; Genome wide association; Replication; TCF7L2
Genes and Coronary Artery Disease : Where Are We?
Keywords: GWAS، مطالعات ارتباطی گسترده در ژنوم; artery; coronary; disease; geneticsCAD, coronary artery disease; GWAS, genome-wide association studies; LDLC, low-density lipoprotein cholesterol; lncRNA, long noncoding RNA; SNP, single-nucleotide polymorphisms
Where Genome Meets Phenome: Rationale for Integrating Genetic and Protein Biomarkers in the Diagnosis and Management of Dilated Cardiomyopathy and Heart Failure
Keywords: GWAS، مطالعات ارتباطی گسترده در ژنوم; biomarker; cardiomyopathy; genomics; personalized medicine; proteomicsBNP, brain natriuretic peptide; DCM, dilated cardiomyopathy; GWAS, genome-wide association studies; HF, heart failure; IDC, idiopathic dilated cardiomyopathy; MMP, matrix metalloprotein
An arrayed human genomic library constructed in the PAC shuttle vector pJCPAC-Mam2 for genome-wide association studies and gene therapy
Keywords: GWAS، مطالعات ارتباطی گسترده در ژنوم; BAC, bacterial artificial chromosome; PAC, P1 artificial chromosome; GWAS, genome-wide association studies; SNP, single nucleotide polymorphism; HGP, Human Genome Project; EBV, Epstein Barr virus; EBNA1, Epstein Barr Nuclear Antigen 1; IPTG, isopropyl β-D
Validation of candidate genes associated with cardiovascular risk factors in psychiatric patients
Keywords: GWAS، مطالعات ارتباطی گسترده در ژنوم; BMI, body mass index; GWAS, Genome-Wide Association Studies; MSE, metabolic side effects; PIMS, Psychotropic Induction and Metabolic Side effects; SGAs, Second Generation AntipsychoticsAntipsychotics; Lipid metabolism; Obesity; Personalized medicine; Phar
Meta-analysis of microarray gene expression studies on intracranial aneurysms
Keywords: GWAS، مطالعات ارتباطی گسترده در ژنوم; genetics; gene expression; intracranial aneurysm; subarachnoid hemorrhage; strokeAVM, arteriovenous malformations; BP, GO Biological Process; CC, GO Cellular Component; ECM, extracellular matrix; GO, gene ontology; GWAS, genome-wide association studies; I