Characterization of in vitro primary metabolic profile of SKLB-M8, a novel antitumor compound, using liquid chromatography coupled with triple quadrupole tandem mass spectrometry and quadrupole time-of-flight tandem mass spectrometry
Keywords: CID, collision-induced dissociation; CLint, intrinsic clearance; DLMs, dog liver microsomes; ESI, electrospray ionization; h, Hill coefficient; HLMs, human liver microsomes; IC50, half maximal inhibitory concentration; IS, internal standard; M1-4, metabol