Keywords: HA، هیالورونان; SC, subcutaneous; IV, intravenous; ID, intradermal; HA, hyaluronan; ECM, extracellular matrix; BTH, bovine testis hyaluronidase; HSA, human serum albumin; rhPH20, recombinant human PH20; rhPH20-HSA, recombinant human PH20-HSA; rhPH20-Fc, recombinant human
مقالات ISI HA، هیالورونان (ترجمه نشده)
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Keywords: HA، هیالورونان; DUB, deubiquitinating enzymes; HABMs, hyaluronan binding motifs; HA, hyaluronan; Ub, ubiquitin; UCH, ubiquitin C-terminal hydrolases; USP, ubiquitin-specific processing proteases; JAMM, Jab1/Pab1/MPN domain-containing metallo-enzymes; OTU, Otu-domain ubiq
Keywords: HA، هیالورونان; bHABP, biotinylated hyaluronan-binding protein; bWFA, biotinylated Wisteria floribunda agglutinin; CNS, central nervous system; CSPG, chondroitin sulfate proteoglycan; DVN, descending vestibular nucleus; ECM, extracellular matrix; HA, hyaluronan; LVN, lat
Hyaluronan ameliorates LPS-induced acute lung injury in mice via Toll-like receptor (TLR) 4-dependent signaling pathways
Keywords: HA، هیالورونان; TLR4, Toll-like receptor-4; ALI, acute lung injury; HA, hyaluronan; LPS, lipopolysaccharide; BALF, bronchial alveolar lavage fluid; WT, wild type; NF-κB, nuclear factor κB; MyD88, Myeloid differentiation primary response protein; HMW-HA, High molecular we
Hyaluronan synthase-2 upregulation protects smpd3-deficient fibroblasts against cell death induced by nutrient deprivation, but not against apoptosis evoked by oxidized LDL
Keywords: HA، هیالورونان; nSMase2, neutral sphingomyelinase type 2; HAS2, hyaluronan synthase 2; HA, hyaluronan; LDL, low density lipoproteinNeutral sphingomyelinase-2; Nutrient starvation; Hyaluronan synthase-2; Oxidized LDL; Apoptosis; Hsp72
Hyaluronan synthase 3 (HAS3) overexpression downregulates MV3 melanoma cell proliferation, migration and adhesion
Keywords: HA، هیالورونان; BSA, bovine serum albumin; bHABC, biotinylated hyaluronan binding complex; fHABC, fluorescent hyaluronan binding complex; EGFP, enhanced green fluorescent protein; HA, hyaluronan; HAS, hyaluronan synthase; PBS, phosphate buffer salineHyaluronan; Melanoma;
The effect of delivering the chemokine SDF-1α in a matrix-bound manner on myogenesis
Keywords: HA، هیالورونان; Polyelectrolyte multilayer film; Drug delivery; SDF-1α/CXCL12; CXCR4; Myoblast; MigrationBMP, bone morphogenetic protein; EDC, 1-ethyl-3-(3-dimethylamino-propyl) carbodiimide; HA, hyaluronan; PDMS, polydimethylsiloxane; PEM, polyelectrolyte multilayer fil
Maintenance of the stemness in CD44+ HCT-15 and HCT-116 human colon cancer cells requires miR-203 suppression
Keywords: HA، هیالورونان; CRC, colorectal carcinoma; CSCs, cancer stem cells; HA, hyaluronan; EMT, epithelial–mesenchymal transition; miRNAs, microRNAs; FCS, fetal calf serum; FACS, fluorescence activated cell sorting; ChIP, chromatin immunoprecipitation; shRNA, short hairpin RNA;
Prolonged synthesis of hyaluronan by Chlorella cells infected with chloroviruses
Keywords: HA، هیالورونان; Hyaluronan; Biosynthesis pathway; Chlorovirus; Infection cycle; AphidicolinGFAT, glutamine:fructose-6-phosphate amidotransferase; GlcA, glucuronic acid; GlcNAc, N-acetylglucosamine; HA, hyaluronan; HAS, hyaluronan synthase; UGDH, UDP-glucose dehydrogenase
Cleavage of hyaluronan is impaired in aged dermal wounds
Keywords: HA، هیالورونان; HA, hyaluronan; HAS, hyaluronan synthase; HYAL, hyaluronidase; MW, molecular weight; ECM, extracellular matrix; GAG, glycosaminoglycanWound healing; Dermis; Age; Mice; Hyaluronan; Hyaluronan synthase; Hyaluronidase
Protein Markers of Malignant Potential in Penile and Vulvar Lichen Sclerosus
Keywords: HA، هیالورونان; penis; vulva; lichen sclerosus et atrophicus; carcinoma, squamous cell; cell transformation, neoplasticCOX-2, cyclooxygenase 2; d-VIN, differentiated VIN; HA, hyaluronan; HG-VIN, high grade VIN; HPV, human papillomavirus; ISCC, invasive vulvar SCC; LS, li
ROS-major mediators of extracellular matrix remodeling during tumor progression
Keywords: HA، هیالورونان; ECM, extracellular matrix; GAG, glycosaminoglycans; EMT, epithelial–mesenchymal transition; HA, hyaluronan; ROS, reactive oxygen species; CS, chondroitin sulfate; DS, dermatan sulfate; HS, heparan sulfate; KS, keratan sulfateTumor; Metastasis; Extracellul
Hyaluronan oligosaccharides perturb lymphocyte slow rolling on brain vascular endothelial cells: Implications for inflammatory demyelinating disease
Keywords: HA، هیالورونان; CDI, cumulative disease index; CNS, central nervous system; EAE, experimental autoimmune encephalomyelitis; EC, endothelial cell; HA, hyaluronan; HA4, HA tetrasaccharide; HA12, HA dodecasaccharide; HMW, high molecular weight; MOG, myelin oligodendrocyte g
Identification and analysis of the human hyaluronan synthase 1 gene promoter reveals Smad3- and Sp3-mediated transcriptional induction
Keywords: HA، هیالورونان; bp, base pairs; DF, dermal fibroblast; ECM, extracellular matrix; gDNA, genomic DNA; HA, hyaluronan; HAS, hyaluronan synthase; IL, interleukin; kb, kilobase pair; PTC, renal proximal tubular epithelial cell; RT-qPCR, reverse transcription-quantitative pol
Hyaluronidase splice variants are associated with histology and outcome in adenocarcinoma and squamous cell carcinoma of the lung
Keywords: HA، هیالورونان; HAase, Hyaluronidases; HA, Hyaluronan; HYAL, hyaluronidase gene; LC, Lung cancerHyaluronidases; Hyaluronan; Alternative splicing; Lung cancer; Prognosis
Increased hyaluronan levels and decreased dendritic cell activation are associated with tumor invasion in murine lymphoma cell lines
Keywords: HA، هیالورونان; bHABP, biotinylated hyaluronic acid binding protein; Da, Dalton; DC, dendritic cells; ECM, extracellular matrix; GAG, glycosaminoglycan; HA, hyaluronan; H–E, hematoxylin–eosin; HAS, HA synthase; Hyal, hyaluronidase; HMW-HA, high molecular weight-HA; i.p.,
A comprehensive model of hyaluronan turnover in the mouse
Keywords: HA، هیالورونان; AUC, area under the curve; BSA, bovine serum albumin; CV, coefficient of variation; DMSO, dimethylsulfoxide; EDTA, ethylenediaminetetraacetic acid; flHA, fluorescein-labeled HA; GPI, glycosylphosphatidylinositol; HA, hyaluronan; HABP, hyaluronan binding p
Sterile Inflammation in the Liver
Keywords: HA، هیالورونان; Inflammasome; TLR; DAMPsASH, alcoholic steatohepatitis; DAMP, damage-associated molecular pattern; HA, hyaluronan; HMGB1, high-mobility group protein B1; IL, interleukin; IL-1R, interleukin 1 receptor; I/R, ischemia/reperfusion; LPS, lipopolysaccharide; N
Growth promoting substrates for human dermal fibroblasts provided by artificial extracellular matrices composed of collagen I and sulfated glycosaminoglycans
Keywords: HA، هیالورونان; Wound healing; Collagen I; Sulfated glycosaminoglycan; Hyaluronan; Chondroitin sulfate; Human dermal fibroblastsGAGs, glycosaminoglycan; Coll, collagen I; dFb, dermal fibroblasts; MFb, myofibroblasts; HA, hyaluronan; HA1.0 (3.0)sulfate groups per disaccha
Hyaluronan deposition and correlation with inflammation in a murine ovalbumin model of asthma
Keywords: HA، هیالورونان; BAL, bronchoalveolar lavage; ECM, extracellular matrix; HA, hyaluronan; HAS, hyaluronan synthase; HYAL, hyaluronidase; IP, intraperitoneal; MBP, major basic protein; OVA, ovalbuminHyaluronan; Inflammation; Asthma; Extracellular matrix
Hyaluronan in human malignancies
Keywords: HA، هیالورونان; ECM, extracellular matrix; HA, hyaluronan; HAS, hyaluronan synthase; RHAMM, receptor for hyaluronan-mediated motility; EMT, epithelial–mesenchymal transition; ROS, reactive oxygen species; SCC, squamous cell carcinoma; EMMPRIN, extracellular matrix metall
Proteoglycan degradation by the ADAMTS family of proteinases
Keywords: HA، هیالورونان; ADAMTS, A Disintegrin And Metalloproteinase with ThromboSpondin motifs; CS, chondroitin sulphate; DS, dermatan sulphate; ECM, extracellular matrix; G1, G2, G3, first, second and third globular domains of lecticans; HA, hyaluronan; IGD, interglobular domai
Mechanism of Binding Site Conformational Switching in the CD44–Hyaluronan Protein–Carbohydrate Binding Interaction
Keywords: HA، هیالورونان; HA, hyaluronan; oHA, oligomeric hyaluronan; GlcNAc, N-acetylglucosamine; GlcUA, glucuronic acid; HABD, hyaluronan binding domain; HA8, eight-residue hyaluronan oligomer; MD, molecular dynamics; PDB, Protein Data Bank; IUPAC, International Union of Pure an
Localized doxorubicin chemotherapy with a biopolymeric nanocarrier improves survival and reduces toxicity in xenografts of human breast cancer
Keywords: HA، هیالورونان; AUC, area-under-the-curve; CDDP, cis-diamminedichloroplatinum(II), cisplatin; Cmax, peak measured concentration of drug; HA, hyaluronan; HA–DOX, Hyaluronan–doxorubicin conjugatePolymeric drug carrier; Localized chemotherapy; Doxorubicin; Breast cancer; Lo
Evolutionary conservation of heavy chain protein transfer between glycosaminoglycans
Keywords: HA، هیالورونان; CS, chondroitin sulfate; GAG, glycosaminoglycan; Gg, Gallus gallus (chicken); HA, hyaluronan; HC, heavy chain; HMW, high molecular weight; IαI, inter-α-inhibitor; MS, mass spectrometry; PαI, pre-α-inhibitor; PGP, protein–glycosaminoglycan–protein; PMF, pe
Hyaluronan oligosaccharides promote excisional wound healing through enhanced angiogenesis
Keywords: HA، هیالورونان; HA, hyaluronan; HMW-HA, high molecular weight HA; o-HA, oligosaccharides of hyaluronan; EC, endothelial cell; ECM, extracellular matrixHyaluronan; Angiogenesis; Wound healing; Oligosaccharides
Molecular size hyaluronan differently modulates toll-like receptor-4 in LPS-induced inflammation in mouse chondrocytes
Keywords: HA، هیالورونان; Hyaluronan; Lipopolysaccharides; Cytokines; Chondrocytes; NF-kB factorDMEM, Dulbecco's modified Eagle's medium; ECM, extracellular matrix; EDTA, ethylenediaminetetraacetic acid; FBS, foetal bovine serum; GAGs, glycosaminoglycans; HA, hyaluronan; HMWHA, hi
Hyaluronan dynamics during retinal development
Keywords: HA، هیالورونان; SPACR, sialoprotein associated with cones and rods; SPACRCAN, sialoproteoglycan associated with cones and rods; HA, hyaluronan; HAS, hyaluronan synthase; HABM, hyaluronan binding molecule; IPM, interphotoreceptor matrix; IPL, inner plexiform layer; PL, ph
Distinct response to heparin by two chicken brain type creatine kinase subunits
Keywords: HA، هیالورونان; ATP, adenosine 5′-triphosphate; b-HA, biotinylated hyaluronan; b-Hep, biotinylated heparin; b-CS, biotinylated chondroitin sulfate; CBB, coomassie brilliant blue; CK, creatine kinase; CS, chondroitin sulfate; GST, glutathione S-transferase; HA, hyaluronan
bFGF induces changes in hyaluronan synthase and hyaluronidase isoform expression and modulates the migration capacity of fibrosarcoma cells
Keywords: HA، هیالورونان; HAS, hyaluronan synthase; HYAL, hyaluronidase; HA, hyaluronan; GAG, glycosaminoglycans; ECM, extracellular matrix; bFGF, basic fibroblast growth factor; RHAMM, Receptor for HA-Mediated MotilityFibrosarcoma; Hyaluronan; Basic fibroblast growth factor; Hyal
Hyaluronan-mediated CD44 activation of RhoGTPase signaling and cytoskeleton function promotes tumor progression
Keywords: HA، هیالورونان; HA, hyaluronan; ECM, extracellular matrix; ARD, ankyrin repeat domain; ERM, Ezrin/Radixin/Moesin; IP3, inositol 1,4,5 trisphosphate; GEFs, guanine nucleotide exchange factors; RGS, regulator of G-protein signaling; DH, dbl homology; PH, pleckstrin homolog
Leukocyte adhesion in the liver: Distinct adhesion paradigm from other organs
Keywords: HA، هیالورونان; Con A, Concanavalin A; HA, Hyaluronan; LAD-1, leukocyte adhesion deficiency type 1; NKT cell, natural killer T cell; RHAMM, Receptor for hyaluronan mediated motility; TLR4, Toll-like receptor 4; Treg, T regulatory cell; VAP-1, Vascular adhesion protein-1L
Hyaluronidase activity is modulated by complexing with various polyelectrolytes including hyaluronan
Keywords: HA، هیالورونان; BSA, bovine serum albumin; CD44, cluster of differentiation 44; ECM, extra-cellular matrix; HA, hyaluronan; HAase, hyaluronidase; HAS, hyaluronan synthase; HN, hyaluronectine; MMP, matrix metalloproteinase; TIMP, tissue inhibitor of matrix metalloproteina
Role of ionic interactions and linker in the domain interaction and modulation of functional activity of hyaluronate lyases
Keywords: HA، هیالورونان; HL, hyaluronate lyase; HA, hyaluronan; SpnHL, Streptococcus pneumoniae hyaluronate lyase; SpnHLv, SpnHL with incorporated two valine in the linker; SpnN, N-terminal or α-domain of SpnHL; SpnNv, SpnN including linker of two extra valine; SpnC, C-terminal d
Electrophoretic separation and characterization of urinary glycosaminoglycans and their roles in urolithiasis
Keywords: HA، هیالورونان; CPC, cetylpyridinium chloride; CS, chondroitin sulfate; CsCl, caesium chloride; DS, dermatan sulfate; GAG, glycosaminoglycan; Gp, glycoprotein; HA, hyaluronan; HPLC, high pressure liquid chromatography; HS, heparan sulfate (f—fast; s—slow); kDa, kilodalto
Prostaglandin E2: A potent activator of hyaluronan synthase 1 in type-B-synoviocytes
Keywords: HA، هیالورونان; HA, Hyaluronan; HAS, hyaluronan synthase; FLS, type-B-synoviocytes; NaSal, sodium salicylate; RA, rheumatoid arthritisHyaluronan; Hyaluronan synthases; Inflammation; Rheumatoid arthritis; Synoviocytes; Prostaglandins
Plasticity of the TSG-6 HA-binding Loop and Mobility in the TSG-6-HA Complex Revealed by NMR and X-ray Crystallography
Keywords: HA، هیالورونان; CUB, complement protein subcomponents C1r/C1s, urchin embryonic growth factor and bone morphogenetic protein 1; ECM, extracellular matrix; GAG, glycosaminoglycan; GlcA, d-glucuronic acid; GlcNAc, N-acetyl-d-glucosamine; HA, hyaluronan; IαI, inter-α-inhibi
Study of the polyelectrolyte multilayer thin films' properties and correlation with the behavior of the human gingival fibroblasts
Keywords: HA، هیالورونان; HA, Hyaluronan; PAH, Poly(allylamine hydrochloride); PGA, Poly(glutamic acid); PLL, Poly(l-lysine); PSS, Poly(styrene sulfonate); n, Number of bilayersPolyelectrolyte multilayer; Wettability; Dynamic contact angle (DCA); Contact angle hysteresis; AFM; Fib
ADAMTS5-mediated aggrecanolysis in murine epiphyseal chondrocyte cultures
Keywords: HA، هیالورونان; ADAMTS, a disintegrin and metalloproteinase with thrombospondin-like motifs; HA, hyaluronan; HABP, hyaluronan binding protein; G1, G2, G3, globular domains of aggrecan; CS, chondroitin sulfate; S-GAG, sulfated glycosaminoglycans; MT4MMP, membrane type-4 m
Complete assignment of hyaluronan oligosaccharides up to hexasaccharides
Keywords: HA، هیالورونان; DQF-COSY, double quantum-filtered correlation spectroscopy; DSS, dimethyl-2-silapentane-5-sulfonate; GlcA, d-glucuronic acid; GlcNAc, N-acetyl-d-glucosamine; HA, hyaluronan; HSQC, heteronuclear single quantum correlation; NOE, nuclear Overhauser enhanceme
A hyaluronan synthase suppressor, 4-methylumbelliferone, inhibits liver metastasis of melanoma cells
Keywords: HA، هیالورونان; HA, Hyaluronan; MU, 4-methylumbelliferone; GAG, glycosaminoglycan; FCS, fetal calf serum; HAS, hyaluronan synthase; PBS, phosphate-buffered saline; UGT, UDP-glucuronosyltransferase4-Methylumbelliferone; Hyaluronan; Melanoma cell; Metastasis; Liver