Hepatitis B virus X protein disrupts stress fiber formation and triggers apoptosis
Keywords: HBx; MLCK; PTEN; Stress-fiber formation; Apoptosis
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Hepatocystin/80K-H inhibits replication of hepatitis B virus through interaction with HBx protein in hepatoma cell
Keywords: Hepatocystin/80K-H; Hepatitis B virus replication; HBx; Molecular chaperon; Protein interaction
Hepatitis B Virus X Protein Inhibits Tumor Suppressor miR-205 through Inducing Hypermethylation of miR-205 Promoter to Enhance Carcinogenesis
Keywords: Aza; 5-Aza-2â²-deoxycytidine; EdU; 5-ethynyl-2â²-deoxyuridine; HBV; hepatitis B virus; HBx; HBV X protein; HCC; hepatocellular carcinoma; miRNA; microRNA; MSP; methylation-specific polymerase chain reaction; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-dipheny
SIRT1 sensitizes hepatocellular carcinoma cells expressing hepatitis B virus X protein to oxidative stress-induced apoptosis
Keywords: HBX; SIRT1; JNK; Oxidative stress; Hepatocellular carcinoma cells
Non-chromatographic Method for the Hepatitis B Virus X Protein Using Elastin-Like Polypeptide Fusion Protein
Keywords: elastin-like polypeptide; HBx; hepatitis B virus; inverse transition cycling; recombinant protein purification
Pro-apoptotic or anti-apoptotic property of X protein of hepatitis B virus is determined by phosphorylation at Ser31 by Akt
Keywords: HBx; Akt; Phosphorylation; Pro-apoptotic; Anti-apoptotic;
Research ArticleHepatitis B virus infection and fatty liver in the general population
Keywords: Anti-HBe; antibody against hepatitis B e antigen; CI; confidence interval; HBeAg; hepatitis B e antigen; HBV; hepatitis B virus; HBx; hepatitis B X; NAFLD; nonalcoholic fatty liver disease; 1H-MRS; proton-magnetic resonance spectroscopy; Nonalcoholic fatt
Hepatitis B virus regulatory HBx protein binding to DDB1 is required but is not sufficient for maximal HBV replication
Keywords: Hepatitis B virus; HBx; DDB1; HBV replication
Design, synthesis, and molecular hybrids of caudatin and cinnamic acids as novel anti-hepatitis B virus agents
Keywords: Synthesis; Molecular hybrids; Caudatin derivatives; Anti-hepatitis B virus; Unique mechanisms; HBV; hepatitis B virus; HBsAg; hepatitis B surface antigen; HBeAg; hepatitis B e antigen; Xp; HBV X promoter; ENI; enhancer 1; ENII; enhancer 2; HBx; HBV X prot
Hepatitis B Virus X Protein Confers Resistance of Hepatoma Cells to Anoikis by Up-regulating and Activating p21-Activated Kinase 1
Keywords: Liver Cancer; Mouse Model; Metastasis; Apoptosis Signal Transduction; HBV; hepatitis B virus; HBx; hepatitis B virus X protein; HCC; hepatocellular carcinoma; Mcl1; myeloid cell leukemia sequence 1; PAK; p21-activated kinase; PI; propidium iodide; PVTT; p
The hepatitis B virus HBx protein modulates cell cycle regulatory proteins in cultured primary human hepatocytes
Keywords: Calcium; Cell cycle; HBx; Hepatitis B virus; Primary human hepatocytes
Interleukin-32 expression induced by hepatitis B virus protein X is mediated through activation of NF-κB
Keywords: HBV, hepatitis B virus; IL-32, interleukin-32; HBx, hepatitis B virus protein XIL-32; HBx; Promoter; NF-κB
The X protein of hepatitis B virus activates hepatoma cell proliferation through repressing melanoma inhibitory activity 2 gene
Keywords: Melanoma inhibitory activity 2 gene; Hepatitis B virus; HBx; Cell growth; Cell proliferation;
Hepatitis B virus X protein reduces starvation-induced cell death through activation of autophagy and inhibition of mitochondrial apoptotic pathway
Keywords: HBx; Cell survival; Apoptosis; Autophagy; Liver cellsHBV, hepatitis B virus; HBx, HBV X protein; HCC, hepatocellular carcinoma; 3-MA, 3-methyladenine; siRNA, small interfering RNA; LC3, microtubule-associated proteins light chain 3; AIF, apoptosis-inducin
Research ArticleHepatitis B virus X protein is essential to initiate and maintain virus replication after infection
Keywords: HBV; hepatitis B virus; HBx; hepatitis B virus X protein; PHH; primary human hepatocytes; cccDNA; covalently closed circular DNA; ChIP; chromatin immunoprecipitation; Hepatitis B virus; HBx protein; Natural infection; Primary human hepatocytes; HepaRG;
Evolving strategies for the treatment of hepatocellular carcinoma: From clinical-guided to molecularly-taylored therapeutic options
Keywords: Hepatocellular carcinoma; HBx; Molecularly targeted therapy; Sorafenib; Sunitinib
Hepatitis B virus X protein stimulates the Hedgehog–Gli activation through protein stabilization and nuclear localization of Gli1 in liver cancer cells
Keywords: HBV; HBx; Gli; Hedgehog; Hepatocellular carcinoma
Functions of Autophagy in Hepatic and Pancreatic Physiology and Disease
Keywords: Steatosis; Cell Death; Pancreatitis; Hepatitis Virus; AT; α1-antitrypsin; Atg; autophagy-related gene; ATP; adenosine triphosphate; CMA; chaperone-mediated autophagy; ER; endoplasmic reticulum; HBx; hepatitis B virus protein X; LAMP-2; lysosome-associate
Hepatitis B Virus Core Promoter Mutations Contribute to Hepatocarcinogenesis by Deregulating SKP2 and Its Target, p21
Keywords: Liver Cancer; Genetics; Virology; Tumorigenesis; BrdU; 5-bromo-2â²-deoxyuridine; combo mutant; T1753A/A1762T/G1764A/T1768A mutant; CP; core promoter; HBx; hepatitis B virus X protein; PHH; primary human hepatocyte; SCF; SKP1/CUL1/F-box ubiquitin ligase c
Molecular biology of the hepatitis B virus and role of the X gene
Keywords: Virus; Cancer; Hepatitis; HBV; HBx; Replication; TranscriptionVirus; Cancer; Hépatite; VHB; Transcription; Réplication
Proteomic analysis of HBV-associated HCC: Insights on mechanisms of disease onset and biomarker discovery
Keywords: Hepatitis B virus (HBV); HBX; Hepatocellular carcinoma (HCC); Prognostic biomarkers;
Lethal-7 is down-regulated by the hepatitis B virus x protein and targets signal transducer and activator of transcription 3
Keywords: HCC; hepatocellular carcinoma; HBV; hepatitis B virus; HBx; hepatitis B virus x protein; miRNA; microRNA; 3â²UTR; 3â² untranslated region; let-7; lethal-7; DMEM; Dulbecco's modified Eagle's media; Cy-3; cyanine-3; Cy-5; cyanine-5; PCR; polymerase ch
Replication of the hepatitis B virus requires a calcium-dependent HBx-induced G1 phase arrest of hepatocytes
Keywords: Hepatitis B Virus; HBx; Viral replication; Calcium; Cell cycle; Primary hepatocytes
A Mutant of Hepatitis B Virus X Protein (HBxÎ127) Promotes Cell Growth through A Positive Feedback Loop Involving 5-Lipoxygenase and Fatty Acid Synthase
Keywords: 5-LOX; 5-lipoxygenase; COX; cyclooxygenase; FAS; fatty acid synthase; HBx; hepatitis B virus X protein; HCC; hepatocellular carcinoma; Indo; indomethacin; LTB4; leukotriene B4; p-ERK1/2; phosphorylated extracellular signal-regulated protein kinases 1/2; S
HBx protein induces EMT through c-Src activation in SMMC-7721 hepatoma cell line
Keywords: HBV, hepatitis B virus; HBx, hepatitis B virus x protein; EMT, epithelial-to-mesenchymal transitionHepatocellular carcinoma; HBx; c-Src; EMT
Hepatitis B virus HBx protein localized to the nucleus restores HBx-deficient virus replication in HepG2 cells and in vivo in hydrodynamically-injected mice
Keywords: Hepatitis B virus; HBx; Nuclear localization; HBV replication;
HBx protein induces expression of MIG and increases migration of leukocytes through activation of NF-κB
Keywords: HBV; MIG; HBx; NF-κB; Promoter; Migration
HBx genotype D represses GSTP1 expression and increases the oxidative level and apoptosis in HepG2 cells
Keywords: HBV; HBx; DNA methylation; GSTP1; HepG2; HepG2.2.15HBV, hepatitis B virus; HBx, hepatitis B virus X; HCC, hepatocellular carcinoma; GSTP1, glutathione S-transferase P1; ROS, reactive oxygen species; DNMT1, DNA methyltransferase 1; MEM, minimal essential m
Epigenetic modification induced by hepatitis B virus X protein via interaction with de novo DNA methyltransferase DNMT3A
Keywords: ChIP; chromatin immunoprecipitation; DAC; 5â²-aza-2â²-deoxycytidine; DNMT; DNA methyltransferase; GFP-Ad; recombinant adenovirus expression green fluorescent protein only; HBx; hepatitis B virus X protein; HBx-Ad; recombinant adenovirus expression both
Ubiquitin-dependent and -independent proteasomal degradation of hepatitis B virus X protein
Keywords: HBV; HBX; Proteasomal degradation; Ub-dependent; Ub-independent
Id-1 Induces Proteasome-dependent Degradation of the HBX Protein
Keywords: HBV, Hepatitis B virus; HCC, hepatocellular carcinoma; HLH, helix-loop-helix; aa, amino acid residuesId-1; HBX; C8; proteasome; degradation
HBx modulates iron regulatory protein 1-mediated iron metabolism via reactive oxygen species
Keywords: Iron; HBx; ROS; IRP1; Total iron level; LIP
Rac1 GTPase is activated by hepatitis B virus replication — involvement of HBX
Keywords: Hepatitis B virus replication; Rac1 activation; Cell morphology; HBX; βPIX
Hepatitis B virus X protein (HBx) activates ATF6 and IRE1-XBP1 pathways of unfolded protein response
Keywords: HBV; HBx; UPR; XBP1; ATF6; GRP78
Expression of Jagged1 and its association with hepatitis B virus X protein in hepatocellular carcinoma
Keywords: Jagged1; Notch signaling; HCC; HBx
Role of hypoxia-inducible factor-α in hepatitis-B-virus X protein-mediated MDR1 activation
Keywords: Chemoresistance; HBx; HIF-1α; MDR1
Tumour suppressors in liver carcinogenesis
Keywords: APC; adenomatous polyposis coli; HBx; Hepatitis B virus protein x; Hh; Hedgehog; HIT; histidine triad; mTOR; mammalian target of rapamycin; PI3K; phosphatidyl-inositide-3OH-kinase; PIP3; phosphatidyl-inositide-3, 4, 5-P3; S6K; S6 kinase;
RNA interference targeting HBx suppresses tumor growth and enhances cisplatin chemosensitivity in human hepatocellular carcinoma
Keywords: HBx; RNAi; Cisplatin; Chemosensitivity; Hepatocellular carcinoma
The interaction of hepatitis B virus X protein and protein phosphatase type 2 Cα and its effect on IL-6
Keywords: PP2Cα; HBx; IL-6; Hepatocellular carcinoma
Hepatocellular carcinoma cells containing hepatitis B virus X protein have enhanced invasive potential conditionally
Keywords: DMEM, Dulbecco's modified Eagle's medium; FBS, foetal bovine serum; HBV, hepatitis B virus; HBx, hepatitis B virus X protein; HCC, hepatocellular carcinoma; RT-PCR, reverse transcription-polymerase chain reactionEukaryotic vector; HBx; Hepatocellular carc
Inhibition of hepatitis B virus X gene expression by 10-23 DNAzymes
Keywords: 10-23 DNAzyme; HBV; HBx; Inhibition; Gene expression;
Macrophage migration inhibitory factor interacts with HBx and inhibits its apoptotic activity
Keywords: MIF; HBx; Apoptosis;
Hepatitis B virus X protein induces apoptosis in hepatoma cells through inhibiting Bcl-xL expression
Keywords: HBx; apoptosis; TNFα; Bcl-xL; Cytochrome c
Functional switch of viral protein HBx on cell apoptosis, transformation, and tumorigenesis in association with oncoprotein Ras
Keywords: HBx; H-Ras; Tumorigenesis; Transformation; Apoptosis
Adhesion contact kinetics of HepG2 cells during Hepatitis B virus replication: Involvement of SH3-binding motif in HBX
Keywords: Cell adhesion; Kinetics; Hepatitis B virus; Extracellular matrix; HBX; Vinexin β; SH3
Interaction of the hepatitis B virus protein HBx with the human transcription regulatory protein p120E4F in vitro
Keywords: Hepatitis B virus; HBx; Hepatocellular carcinoma; Transcription regulation; Protein–Protein interaction; Onco-protein
A proteomics analysis of cellular proteins associated with HBV genotype-specific HBX: potential in identification of early diagnostic markers for HCC
Keywords: HBV; HBX; Genotype; Proteomics; HCC markers;
Human hepatitis B virus X protein induces apoptosis in HepG2 cells: Role of BH3 domain
Keywords: HBX; BH3; Apoptosis;
Effects of hepatitis B virus X protein on human telomerase reverse transcriptase expression and activity in hepatoma cells
Keywords: anti-β-tubulin; antibody to β-tubulin; anti-HBc; antibody to hepatitis B core antigen; anti-HBe; antibody to hepatitis B e antigen; anti-HBs; antibody to hepatitis B surface antigen; anti-HBx; antibody to hepatitis B X antigen; anti-hTERT; antibody to
In vivo hierarchy of immunodominant and subdominant HLA-A*0201-restricted T-cell epitopes of HBx antigen of hepatitis B virus
Keywords: Hepatitis B virus X protein; Cytotoxic T lymphocytes; IFN-γ; HHD transgenic mice; CTL; cytotoxic T lymphocyte; ELISPOT; enzyme-linked immunosorbent spot; HBV; hepatitis B virus; HBx; hepatitis B X protein; HHD; Human/human Db; HLA; human leukocyte antige