Keywords: HC، زنجیره سنگین; BME, 2-mercaptoethanol; CDR, complementary determining regions; CMC, critical micelle concentration; HC, heavy chain; IAM, iodoacetamide; LC, light chain; mAb, monoclonal antibody; NGHC, non-glycosylated heavy chain; PNGase F, peptide N-glycosidase F; TCE
مقالات ISI HC، زنجیره سنگین (ترجمه نشده)
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Keywords: HC، زنجیره سنگین; BoNT, botulinum toxin; CGRP, calcitonin gene related peptide; CSA, cutaneous sensory afferents; DRG, dorsal root ganglion; HC, heavy chain; IPLT, intraplanatar; LC, light chain; MSA, meningeal sensory afferents; NK-1, neurokinin; SNARE, soluble N-ethylale
Solubility of the catalytic domains of Botulinum neurotoxin serotype E subtypes
Keywords: HC، زنجیره سنگین; Botulinum neurotoxin E; Expression; Solubility; SubtypesBoNT, Botulinum neurotoxins; LC, light chain; HC, heavy chain; HCT, translocation domain; HCR, receptor binding domain
Characterization of antibody drug conjugate positional isomers at cysteine residues by peptide mapping LC–MS analysis
Keywords: HC، زنجیره سنگین; ADC, antibody drug conjugates; DAR, drug to antibody ratio; Fc/2, constant fragment of IgG heavy chain; Fd, variable-CH1 fragment of IgG heavy chain; HC, heavy chain; IdeS, immunoglobulin degrading enzyme of Streptococcus pyogenes; IgG, immunoglobulin G;
In vitro generation of rabbit anti-Listeria monocytogenes monoclonal antibody using single cell based RT-PCR linked cell-free expression systems
Keywords: HC، زنجیره سنگین; ELISA, enzyme-linked immunosorbent assay; SICREX, single-cell reverse transcription-PCR linked in vitro-expression; CFPS, cell-free protein synthesis; Hc, heavy chain; Lc, light chain; RT, room temperature; SA beads, DynaBeads M-280 Streptavidin; Fab, fra
The synaptic vesicle protein 2C mediates the uptake of botulinum neurotoxin A into phrenic nerves
Keywords: HC، زنجیره سنگین; BoNT, botulinum neurotoxin; HC, heavy chain; HC, carboxyl-terminal half of HC; HN, amino-terminal half of HC; LC, light chain; SV2, synaptic vesicle glycoprotein 2; Syt, synaptotagmin; Syp, synaptophysin; Syo, Synaptoporin; Syg, SynaptogyrinBotulinum neur
Identification of the synaptic vesicle glycoprotein 2 receptor binding site in botulinum neurotoxin A
Keywords: HC، زنجیره سنگین; BoNT, botulinum neurotoxin; GBS, ganglioside binding site; GST, glutathion-S-transferase; HC, heavy chain; HC, carboxyl-terminal half of HC; HCA, HCE, HCF, HCG, HCX, HC fragment of BoNT serotype A, E, F, G or A-G respectively; HN, amino-terminal half of H
Gene expression measurements normalized to cell number reveal large scale differences due to cell size changes, transcriptional amplification and transcriptional repression in CHO cells
Keywords: HC، زنجیره سنگین; CCI, cell cycle inhibitor; CHO, Chinese Hamster Ovary; ERCC, External RNA Controls Consortium; HC, heavy chain; IRES, Internal Ribosome Entry Site; LC, light chain; mTOR, mammalian target of rapamycin; mTORI, mTOR inhibitor; qP, specific productivity; qPC
Distinct processing of the pre-B cell receptor and the B cell receptor
Keywords: HC، زنجیره سنگین; BCR, B-cell receptor; Endo H, endoglycosidase H; ER, endoplasmic reticulum; Ig, immunoglobulin; HC, heavy chain; LC, light chain; SLC, surrogate light chainB cell receptor; pre-B cell receptor; Receptor internalization; Intracellular protein trafficking
Structural and functional mosaic nature of MHC class I molecules in their peptide-free form
Keywords: HC، زنجیره سنگین; MHC class I; Peptide-free form; β2 microglobulin; NMR; NK cell receptors; Refoldingβ2m, β2microglobulin; CD, circular dichroism; eMHC-I, empty MHC-I; ER, endoplasmic reticulumn; GSH, glutathione; GSSG, glutathione disulfide; HC, heavy chain; HSQC, heteron
Identification and characterization of a novel splice variant of rhesus macaque MHC IA
Keywords: HC، زنجیره سنگین; CHAPS, 3-[(3-cholamidopropyl)-dimethylammonio]-1-propanesulfonate; Endo-H, endoglycosidase-H; HC, heavy chain; ORF, open reading frame; PNGase F, peptide-N-glycosidase; PVDF, polyvinylidene difluorideRhesus macaque; Alternative splicing; MHC IA; Splice va
Human synaptotagmin-II is not a high affinity receptor for botulinum neurotoxin B and G: Increased therapeutic dosage and immunogenicity
Keywords: HC، زنجیره سنگین; BoNT, botulinum neurotoxin; HC, heavy chain; HC, carboxyl-terminal half of HC; HCC, carboxyl-terminal half of HC; HCN, amino-terminal half of HC; HN, amino-terminal half of HC; LC, light chain; SV2, synaptic vesicle glycoprotein 2; hSyt, mSyt, rSyt, human
MAP1B 1–126 interacts with tubulin isoforms and induces neurite outgrowth and neuronal death of cultured cortical neurons
Keywords: HC، زنجیره سنگین; Aß, ß-amyloid; AD, Alzheimer disease; DIV, days in vitro; GST, glutathione-S-transferase; HC, heavy chain; LC, light chain; MAP1B, microtubule associated protein 1B; NFT, neurofibrillary tangleMAP1B; Microtubule binding; Neuronal death; Caspase
Primary sequence determination of a monoclonal antibody against α-synuclein using a novel mass spectrometry-based approach
Keywords: HC، زنجیره سنگین; SILAC, stable isotope labeled amino acids in cell culture; CID, collision induced dissociation; HCD, higher-energy collisiondissociation; CDR, complementary determining region; HC, heavy chain; LC, light chain; MALDI, matrix-assisted laser desorption/ioni
Silencing of a putative inner arm dynein heavy chain results in flagellar immotility in Trypanosoma brucei
Keywords: HC، زنجیره سنگین; RNAi, RNA interference; HC, heavy chain; kb, kilobase; aa, amino acid; PCR, polymerase chain reaction; PFR, paraflagellar rod; ATP, adenosine triphosphate; RT, reverse transcriptase; DAPI, 4′,6-diamidino-2-phenylindole; DIC, differential interference cont
Calcium regulation of the ATPase activity of Physarum and scallop myosins using hybrid smooth muscle myosin: The role of the essential light chain
Keywords: HC، زنجیره سنگین; HMM, heavy meromyosin; SmHMM·HC, smooth muscle HMM heavy chain; ABSF, 4-(2-aminoethyl)-benzenesulfonyl fluoride hydrochloride; HC, heavy chain; LC, light chain; ScRLC, scallop regulatory light chain; ScELC, scallop essential light chain; PhRLC, Physarum r
ER quality control in the biogenesis of MHC class I molecules
Keywords: HC، زنجیره سنگین; Cnx, calnexin; Crt, calreticulin; CST, castanospermine; ER, endoplasmic reticulum; ERAD, ER associated degradation; β2m, β2-microglobulin; HC, heavy chain; HCMV, human cytomegalovirus; PDI, protein disulfide isomerase; PLC, peptide loading complex; TAP, t
Method development and validation of capillary sodium dodecyl sulfate gel electrophoresis for the characterization of a monoclonal antibody
Keywords: HC، زنجیره سنگین; cSDS, capillary sodium dodecy sulfate gel electrophoresis; mAb1, monoclonal antibody; IAM, iodoacetamide; 2-ME, 2-mercaptoethanol; LOQ, limit of quantitation; SDS-PAGE, sodium dodecyl sulfate-polyacrylamide gel electrophoresis; HC, heavy chain; LC, light
Evolutionary conservation of heavy chain protein transfer between glycosaminoglycans
Keywords: HC، زنجیره سنگین; CS, chondroitin sulfate; GAG, glycosaminoglycan; Gg, Gallus gallus (chicken); HA, hyaluronan; HC, heavy chain; HMW, high molecular weight; IαI, inter-α-inhibitor; MS, mass spectrometry; PαI, pre-α-inhibitor; PGP, protein–glycosaminoglycan–protein; PMF, pe
Mechanical Coupling in Myosin V: A Simulation Study
Keywords: HC، زنجیره سنگین; FS, forcing set; NBP, nucleotide-binding pocket; R, rigor; PR, post-rigor; R, rigor; NM, normal mode; NMSM, normal mode superposition model; RTMD, restrained targeted molecular dynamics; OP, order parameter; COM, center of mass; HC, heavy chain; U50, uppe
The On–Off Switch in Regulated Myosins: Different Triggers but Related Mechanisms
Keywords: HC، زنجیره سنگین; RD, regulatory domain; RLC, regulatory light chain; HC, heavy chain; ELC, essential light chain; MLCK, myosin light-chain kinase; HMM, heavy meromyosin; cryo-EM, cryo-electron microscopy; EGTA, ethylene glycol bis(b-aminoethyl ether) N,N′-tetraacetic acid
HLA-B27 Subtypes Differentially Associated with Disease Exhibit Conformational Differences in Solution
Keywords: HC، زنجیره سنگین; MHC, major histocompatibility complex; HLA, human leukocyte antigen; HC, heavy chain; β2m, β2-microglobulin; AS, ankylosing spondylitis; pVIPR, peptide RRKWRRWHL; CTL, cytotoxic T lymphocytes; DSC, differential scanning calorimetry; IR, infrared; MD, mole
Structure, expression and function of HLA-G in renal cell carcinoma
Keywords: HC، زنجیره سنگین; β2-m, β2-microglobulin; APC, antigen presenting cell; APM, antigen processing machinery; ccRCC, RCC of the clear cell subtype; CTL, cytotoxic T lymphocyte; DAC, desoxyazacytidine; HC, heavy chain; IFN, interferon; IL, interleukin; KIR, killer inhibitory r
New display vector reduces biological bias for expression of antibodies in E. coli
Keywords: HC، زنجیره سنگین; aa, amino acid(s); AP, alkaline phosphatase; Ap, ampicillin; CDR, complementarity determining region; CEA, carcinoembryonic antigen; GST, glutathione S-transferase; HC, heavy chain; HRP, horseradish peroxidase; IPTG, isopropyl b-d-thiogalactopyranoside; K
Single variable domain antibody as a versatile building block for the construction of IgG-like bispecific antibodies
Keywords: HC، زنجیره سنگین; BsAb, Bispecific antibody; HRP, horse radish peroxidase; HC, heavy chain; LC, light chain; mPDGFRα, mouse PDGF receptor α; mPDGFRβ, mouse PDGF receptor β; PBS, phosphate buffered saline; PDGF, platelet derived growth factor; RT, room temperature; sVD, sin
The κ-like pre-B receptor: Surplus biology or a missing link?
Keywords: HC، زنجیره سنگین; Ag, antigen; BCR, B cell receptor; Ig, immunoglobulin; HC, heavy chain; LC, light chain; SLC, surrogate light chains; V(D)J, variable diversity joiningB-lymphocytes; Development; Immunoglobulin genes; Surrogate light chains; Bone marrow stroma
Heterotypic complex formation between subunits of microtubule-associated proteins 1A and 1B is due to interaction of conserved domains
Keywords: HC، زنجیره سنگین; HRP, horse radish peroxidase; MAP, microtubule-associated protein; MH, MAP1 homology; HC, heavy chain; LC, light chain; SDS-PAGE, SDS-polyacrylamide gel electrophoresisMicrotubule-associated protein; Multimeric protein complex; Protein–protein interaction
Human cytomegalovirus-encoded US2 and US11 target unassembled MHC class I heavy chains for degradation
Keywords: HC، زنجیره سنگین; β2m, β2-microglobulin; BiP, immunoglobulin binding protein; CNX, calnexin; CRT, calreticulin; HC, heavy chain; PDI, protein disulfide isomerase; TAP, transporter associated with antigen processing; US, unique shortImmune escape; MHC class I; Protein degra
A Structural Perspective of the Sequence Variability Within Botulinum Neurotoxin Subtypes A1-A4
Keywords: HC، زنجیره سنگین; BoNT, botulinum neurotoxin; HC, heavy chain; HC, C-terminal binding domain of the heavy chain; HCN, N-terminal lectin subdomain of the binding domain; HCC, C-terminal trefoil subdomain of the binding domain; HN, N-terminal translocation domain of the heav
Electron Tomography of Swollen Rigor Fibers of Insect Flight Muscle Reveals a Short and Variably Angled S2 Domain
Keywords: HC، زنجیره سنگین; S1, subfragment 1; S2, subfragment 2; HC, heavy chain; ELC, essential light chain; HMM, heavy meromyosin; smHMM, smooth muscle HMM; LMM, light meromyosin; IFM, insect flight muscle; EM, electron microscopy; RLC, regulatory light chain; S/N, signal-to-nois
Conformational sampling of the botulinum neurotoxin serotype a light chain: implications for inhibitor binding
Keywords: HC، زنجیره سنگین; BoNT, botulinum neurotoxin; BoNT/A, botulinum neurotoxin serotype A; BoNT/B, botulinum neurotoxin serotype B; LC, light chain; HC, heavy chain; Rmsd, rms deviation; Bioterrorism; Botulinum neurotoxin; Drug discovery; Inhibitors; Molecular dynamics; Molecu