دانلود مقالات ISI درباره HDACs، هیستون deacetylases + ترجمه فارسی

طراحی و سنتز پروفیل پروتئینی مبتنی بر فعالیت حاصل از اسید هیدروکسامیک سینامیک

Design and synthesis of an activity-based protein profiling probe derived from cinnamic hydroxamic acid

Keywords: HDACs، هیستون deacetylases; ABPP, activity-based protein profiling; ADME, absorption, distribution, metabolism, and excretion; DAAs, direct-acting antivirals; DPBS, Dulbecco’s phosphate-buffered saline; HCV, hepatitis C virus; HDACs, histone deacetylases; HTAs, host-targeting antivi

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

مدولاسیون اپی ژنتیک توسط مجتمع های فلزی معدنی

Epigenetic modulation by inorganic metal complexes

Keywords: HDACs، هیستون deacetylases; Transition metal complexes; Epigenetic; Epidrugs; Histone; Chromatin-modifying enzymesDNMTs, DNA methyltransferase enzymes; R, arginine; K, lysine; S, serine; T, threonine; HATs, histone acetyl transferases; HDACs, histone deacetylases; lncRNA, long nonco

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

والپروات سدیم فیبروز ناشی از دیابت و آسیب کلیه توسط مهار هیستون دیازکتیلاز در رت دیابتی کاهش می یابد

Sodium valproate ameliorates diabetes-induced fibrosis and renal damage by the inhibition of histone deacetylases in diabetic rat

Keywords: HDACs، هیستون deacetylases; α-SMA, Alpha smooth muscle actin; COX-2, Cyclooxygenase 2; CTGF, Connective tissue growth factor; DAB, 3,3′-Diaminobenzidine; ECM, Extracellular matrix; HDACs, Histone deacetylases; ICAM-1, Intercellular adhesion molecule 1; MMP-2, Matrix metalloproteinas

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

High-throughput screening of Sirtuin family of genes in breast cancer

Keywords: HDACs، هیستون deacetylases; BC, breast cancer; cDNA, complementary DNA; DMEM, Dulbecco's modified eagle's medium; FBS, fetal bovine serum; NAD, nicotinamide adenine dinucleotide; HDACs, histone deacetylases; HNSCC, head and neck squamous cell carcinoma; HCC, hepatocellular carcinoma

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors

Keywords: HDACs، هیستون deacetylases; HATs, histone acetyl transferases; HDACs, histone deacetylases; SAR, structure activity relationship; SKR, structure kinetic relationship; T1/2, half-lifeHDAC inhibitors; Isoform selectivity; Kinetic selectivity; Target engagement; Acetylation

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Increased apoptosis and abnormal visual behavior by histone modifications with exposure to para-xylene in developing Xenopus

Keywords: HDACs، هیستون deacetylases; AI, avoidance index; CNS, central nervous system; FETAX, frog embryo teratogenesis assay-Xenopus; GA, d-glucuronolactone; HDACs, histone deacetylases; HEPES, 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid; PX, para-xyleneXenopus; para-xylene; apoptosi

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Synthesis of chiral ND-322, ND-364 and ND-364 derivatives as selective inhibitors of human gelatinase

Keywords: HDACs، هیستون deacetylases; MMP2, matrix metalloproteinase 2; MMP9, matrix metalloproteinase 9; APN, aminopeptidase N; HDACs, histone deacetylases; MMPs, matrix metalloproteinases; ECM, extracellular matrix; CEs, Cotton effects; PTSC, paratoluenesulfonyl chloride; DCM, dichlorometha

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

SIRT1 is a regulator of autophagy: Implications in gastric cancer progression and treatment

Keywords: HDACs، هیستون deacetylases; GC, gastric cancer; SIRT1, silent mating type information regulation 1; HDACs, histone deacetylases; PCD, programmed cell death; TSC2, tuberous sclerosis complex 2; ATGs, autophagy-related genes; EMT, epithelial-mesenchymal transition; MDR, multidrug resi

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Three single nucleotide variants of the HDAC gene are associated with type 2 diabetes mellitus in a Chinese population: A community-based case–control study

Keywords: HDACs، هیستون deacetylases; Type 2 DM, type 2 diabetes mellitus; SNP, single nucleotide polymorphism; HDACs, histone deacetylases; IGR, impaired glucose regulation; MAF, minor allele frequency; BMI, body mass index; ORG, generalized odds ratioCase–control study; Histone deacetylase;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Involvement of epigenetics and microRNA-29b in the urethane induced inception and establishment of mouse lung tumors

Keywords: HDACs، هیستون deacetylases; TSG, tumor suppressor gene; miR-29b, microRNA-29b; MBDs, methyl CpG binding domain proteins; DNMTs, DNA 5-cytosinemethyltransferases; HDACs, histone deacetylases; MLH1, MutL Homologue 1; IL-6, interleukin 6; MS-PCR, methylation-specific PCR; RT-PCR, rever

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Prenatal nicotinic exposure suppresses fetal adrenal steroidogenesis via steroidogenic factor 1 (SF-1) deacetylation

Keywords: HDACs، هیستون deacetylases; StAR, steroidogenic acute regulatory; IUGR, intrauterine growth retardation; SF-1, steroidogenic factor-1; TSA, trichostatin A; HDACs, histone deacetylases; HPA, hypothalamic–pituitary–adrenal; CORT, corticosterone; P450scc, cholesterol side chain cleavag

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Protective role of sodium butyrate, a HDAC inhibitor on beta-cell proliferation, function and glucose homeostasis through modulation of p38/ERK MAPK and apoptotic pathways: Study in juvenile diabetic rat

Keywords: HDACs، هیستون deacetylases; ERK, extracellular signal-regulated kinase; FOXO, forkhead box protein O; HDACs, histone deacetylases; IPGTT, intraperitoneal glucose tolerance test; IRS-1, insulin receptor substrate-1; MAPK, mitogen-activated protein kinase; PCNA, proliferating cell nuc

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

Inhibition of monomethylarsonous acid (MMAIII)-induced cell malignant transformation through restoring dysregulated histone acetylation

Keywords: HDACs، هیستون deacetylases; HATs, histone acetyltransferases; HDACs, histone deacetylases; iAs, inorganic arsenic; MMAIII, monomethylarsonous acid; SAHA, suberoylanilide hydroxamic acidArsenic; Cell malignant transformation; HDAC inhibitor; Histone acetylation; Monomethylarsonous ac

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

HDAC inhibitors dysregulate neural stem cell activity in the postnatal mouse brain

Keywords: HDACs، هیستون deacetylases; HDACs, histone deacetylases; HDACi, HDAC inhibitors; SVZ, subventricular zone; DG, dentate gyrus; RMS, rostral migratory stream; OB, olfactory bulb; VPA, valproic acid; P, postnatal day; DIV, days in vitro; OE, olfactory epithelium; ORN, olfactory recepto

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2013 سفارش ترجمه

Epigenetic histone acetylation and deacetylation mechanisms in experimental models of neurodegenerative disorders

Keywords: HDACs، هیستون deacetylases; MPP+, 1-methyl-4-phenylpyridinium; 4-PBA, 4-phenylbutyrate; AD, Alzheimer's disease; Aβ, amyloid-beta peptide; APP, β-amyloid precursor protein; HAT, histone acetyl transferase; HDACs, histone deacetylases; HD, Huntington's disease; PD, Parkinson's diseas

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Imidazo–benzothiazoles a potent microRNA modulator involved in cell proliferation

Keywords: HDACs، هیستون deacetylases; miRNAs, microRNAs; RISC, RNA induced silencing complex; UTR, untranslated region; siRNAs, small interfering RNAs; HDACs, histone deacetylases; DIAP1, Drosophila inhibitor of apoptosis1MicroRNA; HDAC; Bantam; Imidazo–benzothiazoles; Colon cancer

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Memory impairment induced by brain iron overload is accompanied by reduced H3K9 acetylation and ameliorated by sodium butyrate

Keywords: HDACs، هیستون deacetylases; sodium butyrate; object recognition; inhibitory avoidance; neurodegeneration; iron; histone acetylationHDACi, HDAC inhibitor; HDACs, histone deacetylases; IA, inhibitory avoidance; LTM, long-term memory; NaB, sodium butyrate; OR, object recognition

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Non-histone lysine acetylated proteins in heart failure

Keywords: HDACs، هیستون deacetylases; C.I., confidence interval; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; HATs, histone acetyltransferases; HDACs, histone deacetylases; HDACis, histone deacetylase inhibitors; LCAD, long-chain acyl-CoA dehydrogenase; LV EF, left ventricular ejection fr

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Nmnat2 protects cardiomyocytes from hypertrophy via activation of SIRT6

Keywords: HDACs، هیستون deacetylases; SIRT, sirtuin; NAD, nicotinamide adenine dinucleotide; Nmnat, nicotinamide mononucleotide adenylyltransferase; Ang II, angiotensin II; HDACs, histone deacetylases; Nampt, nicotinamide phosphoribosyltransferase; AAC, abdominal aortic constriction; ANF, atr

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Calcium/calmodulin-dependent protein kinase II regulates IL-10 production by human T lymphocytes: A distinct target in the calcium dependent pathway

Keywords: HDACs، هیستون deacetylases; Ca2+, calcium; CaM, calmodulin; CaMK, Ca2+/calmodulin-dependent protein kinases; CaMKII, Ca2+/calmodulin-dependent protein kinase II; CaMKIV, Ca2+/calmodulin-dependent protein kinase IV; HDACs, histone deacetylases; I, Ionomycin; I/PMA, Ionomycin/PMA; MEF

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Metallothionein expression in colorectal cancer: relevance of different isoforms for tumor progression and patient survival

Keywords: HDACs، هیستون deacetylases; AFC, average fold change; CI, confidence interval; CRC, colorectal cancer; DAC, 5-aza-2′-deoxycytidine; HDACs, histone deacetylases; HR, hazard ratio; IHC, immunohistochemistry; MSP, methylation-specific PCR; MT, metallothioneinMetallothioneins; Colorecta

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

Proteomics in chromatin biology and epigenetics: Elucidation of post-translational modifications of histone proteins by mass spectrometry

Keywords: HDACs، هیستون deacetylases; ChIP, chromatin immunoprecipitation; DNMTs, DNA methyltransferases; ECD, electron capture dissociation; ETD, electron transfer dissociation; HDACs, histone deacetylases; HILIC, hydrophilic interaction liquid chromatography; O-GlcNAc, O-linked N-acetylgluc

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2012 سفارش ترجمه

The short chain fatty acid sodium butyrate regulates the induction of CD1a in developing dendritic cells

Keywords: HDACs، هیستون deacetylases; DCs, dendritic cells; DMSO, dimethyl sulfoxide; FBS, foetal bovine serum; HDACs, histone deacetylases; MHC, major histocompatibility complex; NaB, sodium butyrate; PBS, phosphate buffered saline; PPAR-γ, peroxisome proliferator-activated receptor γ; QRT-P

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Regulation of histone acetylation in the hippocampus of chronically stressed rats: a potential role of sirtuins

Keywords: HDACs، هیستون deacetylases; epigenetics; chronic stress; hippocampus; histone deacetylases; depression; sirtuinsCVS, chronic variable stress; DG, dentate gyrus; HATs, histone acetyltransferases; HDACs, histone deacetylases; H3, histone 3; H4, histone 4; NaB, sodium butyrate; NAD+, n

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Analysis of histone acetyltransferase and deacetylase families of Vitis vinifera

Keywords: HDACs، هیستون deacetylases; Vitis vinifera; Genome analysis; Gene expression; Histone acetyltransferase; Histone deacetylase; GrapesHATs, histone acetyltransferases; HDACs, histone deacetylases

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Protection of dopaminergic cells from MPP+-mediated toxicity by histone deacetylase inhibition

Keywords: HDACs، هیستون deacetylases; DA, Dopamine; PD, Parkinson's disease; MPP+, 1-methyl-4-phenylpyridinium; HDACs, Histone deacetylases; HDACIs, Histone deacetylase inhibitors; NaB, Sodium butyrate; VPA, Valproic acid; SAHA, Suberoylanilide hydroxamic acid; IAP's, Inhibitors of Apoptosis;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

The Histone Demethylase RBP2 Is Overexpressed in Gastric Cancer and Its Inhibition Triggers Senescence of Cancer Cells

Keywords: HDACs، هیستون deacetylases; Cellular Senescence; Histone Demethylationβ2-M, β2-microglobulin; CDKIs, cyclin-dependent kinase inhibitors; GC, gastric cancer; HDACs, histone deacetylases; HDM, histone demethylase; QRT-PCR, quantitative real-time PCR; SA-β-Gal, senescence-associated β-

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2010 سفارش ترجمه

Epigenetic regulation and the pathogenesis of systemic lupus erythematosus

Keywords: HDACs، هیستون deacetylases; 5-azaC, 5-azacytidine; DNMT, DNA methyltransferase; dsDNA, double-stranded DNA; ERK, extracellular signal-regulated kinase; HATs, histone acetyltransferases; HDACs, histone deacetylases; IFN-γ, interferon-γ; IgG, immunoglobulin-G; IL, interleukin; MBD, me

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2009 سفارش ترجمه

Anti-neuroblastoma activity of Helminthosporium carbonum (HC)-toxin is superior to that of other differentiating compounds in vitro

Keywords: HDACs، هیستون deacetylases; HDACs, histone deacetylases; HDACIs, HDAC-inhibitors; MS-275, N-(2-aminophenyl)-4-[N-(pyridine-3-ylmethoxy-carbonyl)aminomethyl]benzamide; NB, neuroblastoma; RA, retinoic acid; ATRA, all-trans RA; RB, retinoblastoma tumor suppressor protein; pRB, hypophos

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2008 سفارش ترجمه

Blimp-1Δexon7: A naturally occurring Blimp-1 deletion mutant with auto-regulatory potential

Keywords: HDACs، هیستون deacetylases; Blimp-1, B lymphocyte-induced maturation protein 1; LPS, lipopolysaccharide; HDACs, histone deacetylases; Ig, immunoglobulinBlimp-1; prdm-1; B cell differentiation; Apoptosis; HDAC; Heterochromatin; Auto-regulatory feedback; Homodimerization

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2008 سفارش ترجمه

Cell shape regulates global histone acetylation in human mammary epithelial cells

Keywords: HDACs، هیستون deacetylases; ECM, extracellular matrix; lrECM, laminin-rich reconstituted ECM; HATs, histone acetyltransferases; HDACs, histone deacetylases; polyHEMA, poly(2-hydroxyethyl methacrylate); TPA, 12-o-tetradecanoylphorbol 13-acetate; 2D, two-dimension(al); 3D, three-dimen

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2007 سفارش ترجمه

DNA methylation paradigm shift: 15-Lipoxygenase-1 upregulation in prostatic intraepithelial neoplasia and prostate cancer by atypical promoter hypermethylation

Keywords: HDACs، هیستون deacetylases; 5-aza-dC, 5-aza-2′-deoxycytidine; COBRA, combined bisulfite restriction analysis; HDACs, histone deacetylases; 15-LO-1, 15-lipoxygenase-type 1; TSA, trichostatin-A15-Lipoxygenase-1 (15-LO-1); Promoter; Methylation; Prostate cancer; High-grade PIN; Normal;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2007 سفارش ترجمه

An epigenetic perspective on the free radical theory of development

Keywords: HDACs، هیستون deacetylases; BSO, buthionine sulfoximine; DNMTs, DNA methyltransferases; FIH, factor inhibiting HIF; HDACs, histone deacetylases; HIF, hypoxia inducible factor; HMTs, histone methyltransferases; H2O2, hydrogen peroxide; MAT, methionine adenosyltransferase; 5-MeC, 5-me

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2007 سفارش ترجمه