Keywords: Knotted protein; Protein folding; SAXS; HDX-MS; Ornithine transcarbamylase;
مقالات ISI (ترجمه نشده)
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Keywords: BLUF; sensors of blue light using flavin; FAD; flavin adenine dinucleotide; AC; adenylyl cyclase; bPAC; Beggiatoa photoactivatable AC; HDX-MS; hydrogen-deuterium exchange mass spectrometry; solACshort; short isoform of human soluble AC; BLUF photorecept
Keywords: CDH; cellobiose dehydrogenase; DH; dehydrogenase (domain); CYT; cytochrome (domain); HDX-MS; hydrogen/deuterium exchange mass spectrometry; IET; interdomain electron transfer; IM-MS; ion mobility mass spectrometry; Cellobiose dehydrogenase; Direct electro
Keywords: 2D-LC; two-dimensional liquid chromatography; AA; amino acid; AC; affinity chromatography; ADC; antibody-drug conjugates; ADCC; antibody-dependent cellular cytotoxicity; AF4; asymmetric flow field fractionation; APTS; 1-aminopyrene-3,6,8-trisulfonate; Asn
Redox exchange of the disulfides of human two-domain CD4 regulates the conformational dynamics of each domain, providing insight into its mechanisms of control
Keywords: Cluster of differentiation 4; HIV gp120; Allosteric disulfide bond; Mass spectrometry; Hydrogen-deuterium exchange; Protein dynamics; CD4; cluster of differentiation 4; D1-D4; domain 1 to 4 of CD4; 2dCD4; two domain CD4 variant comprising both domain 1 an
Crystal structures of the disease-causing D444V mutant and the relevant wild type human dihydrolipoamide dehydrogenase
Keywords: h; human; E3; (dihydro)lipoamide dehydrogenase, the common E3 component of the mitochondrial 2-oxo acid dehydrogenase complexes; LADH; (dihydro)lipoamide dehydrogenase; KGDHc; alpha-ketoglutarate (also known as 2-oxoglutarate) dehydrogenase complex; PDHc;
G protein-coupled receptor kinases: Past, present and future
Keywords: αN-helix; N-terminal α-helical domain; α2AAR; α2A-adrenergic receptor; AST; active site tether; βAR; β-adrenergic receptor; β2AR; β2-adrenergic receptor; βARK; β-adrenergic receptor kinase; CLBD; C-terminal lipid binding domain; EM; electron mic
Ordered opening of LDL receptor binding domain of human apolipoprotein E3 revealed by hydrogen/deuterium exchange mass spectrometry and fluorescence spectroscopy
Keywords: Apolipoprotein E3; Helix bundle opening; LDL receptor; Hydrogen deuterium exchange mass spectrometry; Fluorescence spectroscopy; Lipoprotein binding; apoE3; apolipoprotein E3; CD; circular dichroism; CT; C-terminal; GdnHCl; guanidine hydrochloride; FI; fl
Installation, validation, and application examples of two instrumental setups for gas-phase HDX-MS analysis of peptides and proteins
Keywords: HDX; hydrogen/deuterium exchange; HDX-MS; hydrogen/deuterium exchange coupled to mass spectrometry; ND3; deuterated ammonia; pND3; partial pressure of ND3; TWIG; traveling wave ion guide; Gas-phase hydrogen/deuterium exchange mass spectrometry; Gas-phase
Key residues controlling bidirectional ion movements in Na+/Ca2+ exchanger
Keywords: NCX; sodium-calcium exchanger; CBD; calcium binding domain; Mops; 3-(N-morpholino)propanesulfonic acid; Tris; tris(hydroxymethyl)-aminomethane; HEPES; 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid; MES; 2-(N-morpholino)ethanesulfonic acid; Fluo-3;
Intrinsically disordered N-terminal domain of the Helicoverpa armigera Ultraspiracle stabilizes the dimeric form via a scorpion-like structure
Keywords: NRs; nuclear receptors; NTD; N-terminal domain; DBD; DNA-binding domain; LBD; ligand-binding domain; EcR; ecdysone receptor; Usp; Ultraspiracle; IDR; intrinsically disordered region; HaUsp; Usp from Helicoverpa armigera; HaUsp_ÎNTD; Usp from Helicoverpa
H/D exchange mass spectrometry and statistical coupling analysis reveal a role for allostery in a ferredoxin-dependent bifurcating transhydrogenase catalytic cycle
Keywords: FBEB; flavin-based electron bifurcation; HDX-MS; H/D exchange mass spectrometry; #D; absolute number of deuterium incorporated; %D; percentage of deuterium incorporated; SCA; Statistical Coupling Analysis; Nfn; NADH-dependent ferredoxin-NADP+ oxidoreducta
Synergistic stabilisation of NOsGC by cinaciguat and non-hydrolysable nucleotides: Evidence for sGC activator-induced communication between the heme-binding and catalytic domains
Keywords: ANOVA; analysis of variance; BSA; bovine serum albumin; DMSO; dimethyl sulfoxide; DSF; differential scanning fluorimetry; EM; electron microscopy; FRET; Förster resonance energy transfer; HDX-MS; hydrogen/deuterium exchange mass spectrometry; HNOX; heme-
Mutation goals in the vitamin D receptor predicted by computational methods
Keywords: VD; vitamin D; VDR; vitamin D receptor; 1,25D; 1α,25-(OH)2D3; LBP; ligand binding pocket; RXR; retinoid X receptor; VDRRE; vitamin D receptor response element (DNA-DR3); VDRR; vitamin D-resistant rickets; SRC; steroid receptor coactivator; DRIP; vitamin
Human dihydrolipoamide dehydrogenase (E3) deficiency: Novel insights into the structural basis and molecular pathomechanism
Keywords: E3-deficiency; Dihydrolipoamide dehydrogenase; Alpha-ketoglutarate dehydrogenase complex; Pyruvate dehydrogenase complex; Pathogenic mutation; KGDHc; alpha-ketoglutarate (also known as 2-oxoglutarate) dehydrogenase complex; KG; alpha-ketoglutarate; PDHc;
Identification of cytidine-5-triphosphate synthase1-selective inhibitory peptide from random peptide library displayed on T7 phage
Keywords: CTPS; Cytidine-5-prime-triphosphate synthase; AMP-PCP; adenosine 5â²-[beta,gamma-methylene]triphosphate; ITC; Isothermal Titration Calorimetry; HDX-MS; Hydrogen/Deuterium eXchange and Mass Spectrometry; CTPS1; Peptide; Phage display; HDX-MS;
The effects of mutating Tyr9 and Arg15 on the structure, stability, conformational dynamics and mechanism of GSTA3-3
Keywords: CD; circular dichroism; CDNB; 1-chloro-2, 4-dinitrobenzene; EDTA; ethylenediaminetetraacetic acid; GSH; glutathione; GST; glutathione S-transferase; HDX-MS; hydrogen-deuterium exchange mass spectrometry; ITC; isothermal titration calorimetry; PDB; Prote
Chikungunya virus nsP4 RNA-dependent RNA polymerase core domain displays detergent-sensitive primer extension and terminal adenylyltransferase activities
Keywords: Chikungunya; RdRP; HDX-MS; Fluorescence anisotropy; Homology modelling;
R468A mutation in perfringolysin O destabilizes toxin structure and induces membrane fusion
Keywords: DLS; dynamic light scattering; DOPC; 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine; GST-PFO; glutathione-S-transferase-tagged wild type perfringolysin O; GST-PFOR468A; glutathione-S-transferase-tagged R468A perfringolysin O; HDX-MS; hydrogen deuter
Molecular perspective of antibody aggregates and their adsorption on Protein A resin
Keywords: Antibody aggregate; Protein A adsorption; Higher order structure; HDX-MS; Protein Conformational Array; Molecular modelling
Conformational modulation of the farnesoid X receptor by prenylflavonoids: Insights from hydrogen deuterium exchange mass spectrometry (HDX-MS), fluorescence titration and molecular docking studies
Keywords: FXR; farnesoid X receptor; HDX-MS; hydrogen deuterium exchange mass spectrometry; MetS; metabolic syndromes; SHP; small heterodimer partner; BSEP; bile salt export pump; LBD; ligand binding domain; XN; xanthohumol; IX; isoxanthohumol; 8-PN; 8-prenylnarige
Conformational epitope mapping of Pru du 6, a major allergen from almond nut
Keywords: Almond; Epitope mapping; Monoclonal antibody; HDX-MS; Allergy
Theory of the protein equilibrium population snapshot by H/D exchange electrospray ionization mass spectrometry (PEPS-HDX-ESI-MS) method used to obtain protein folding energies/rates and selected supporting experimental evidence
Keywords: PEPS; HDX-MS; ESI-MS; Protein folding; Protein folding energy; Protein structure; H/D exchange mass spectrometry; Protein stability; Protein folding kinetics
The high-throughput protein sample production platform of the Northeast Structural Genomics Consortium
Keywords: Structural genomics; High-throughput protein production; Construct optimization; Disorder prediction; Ligation-independent cloning; Multiple Displacement Amplification; Laboratory Information Management System; Protein Structure Initiative; NMR; X-ray cry