Keywords: Virtual cell based assay (VCBA); HepG2; HepaRG; Repeated exposure;
مقالات ISI (ترجمه نشده)
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Keywords: NRU; neutral red uptake; HTS; high throughput screening; CYP; cytochrome P450; OD; optical density; HepaRG; HepG2; Automation; In vitro test system; Basal cytotoxicity; NRU;
Metabolomics profiling of steatosis progression in HepaRG® cells using sodium valproate
Keywords: ACN; acetonitrile; ADP; adenosyl-diphosphate; AM/MS; accurate mass/mass spectrometry; ATP; adenosyl-triphosphate; BHT; butyl-hydroxytoluene; CAWG; chemical analysis working group (metabolomics society); Cer; ceramide; CHCl3; chloroform; DG; diacylglycerol
AMC-Bio-Artificial Liver culturing enhances mitochondrial biogenesis in human liver cell lines: The role of oxygen, medium perfusion and 3D configuration
Keywords: Mitochondrial biogenesis; Bio-artificial liver; HepaRG; C3A; Hepatocyte; ABCA12; ATP binding cassette subfamily A member 12; ACO2; aconitase 2; AMC; Amsterdam Medical Center; BAL; bio-artificial liver; BALIAD; bio-artificial liver-in-a-dish; CEBPa; CCAAT/
Relative potency of fifteen pyrrolizidine alkaloids to induce DNA damage as measured by micronucleus induction in HepaRG human liver cells
Keywords: Pyrrolizidine alkaloids; HepaRG; Genetic toxicology; Micronucleus test; Relative potency factor; Risk assessment; BMD; benchmark dose; CEF; critical effect size; CEDL; lower confidence interval of the critical effect dose; CEDU; upper confidence interval
In vitro co-culture models to evaluate acute cytotoxicity of individual and combined mycotoxin exposures on Caco-2, THP-1 and HepaRG human cell lines
Keywords: Co-culture; Caco-2; HepaRG; THP-1; Mycotoxins; Cytotoxicity; DMSO; Dimethylsulfoxide; DON; Deoxynivalenol; IC10; Inhibitory concentration 10%; IC30; Inhibitory concentration 30%; LC-MS; Liquid chromatography coupled to mass spectrometry; MTS; (3-(4,5-dime
Metabolomics study of early metabolic changes in hepatic HepaRG cells in response to rosemary diterpenes exposure
Keywords: Metabolomics; HepaRG; Rosemary; Diterpenes; Carnosic acid; Carnosol; Rosmanol;
Cell-based assay using glutathione-depleted HepaRG and HepG2 human liver cells for predicting drug-induced liver injury
Keywords: AUC; area under receiver operating characteristic curve; BSO; L-buthionine-S,R-sulfoximine; BW; boxed warning; Cmax; therapeutic maximum plasma concentration; CYP; cytochrome P450; DILI; drug-induced liver injury; DMSO; dimethyl sulfoxide; FBS; fetal bovi
The utility of HepaRG cells for bioenergetic investigation and detection of drug-induced mitochondrial toxicity
Keywords: Mitochondria; Drug-induced liver injury; HepaRG; Seahorse; Glucose/galactose; Bioenergetic phenotype; ALR; ATP-linked respiration; BCA; bicinchoninic Acid; BR; basal respiration; CCCP; cyanide m-chlorophenyl hydrazine; CPT; carnitine palmitoyl transferase
Tailored liquid chromatography-mass spectrometry analysis improves the coverage of the intracellular metabolome of HepaRG cells
Keywords: HepaRG; Metabolomics; Optimization; Liquid chromatography-Mass spectrometry; Hydrophilic liquid interaction chromatography; Ion pairing;
Virtual Cell Based Assay simulations of intra-mitochondrial concentrations in hepatocytes and cardiomyocytes
Keywords: VCBA; Mitochondrial membrane potential; HepaRG; ICell cardiomyocyte; In silico; In vitro;
Pooled human liver preparations, HepaRG, or HepG2 cell lines for metabolism studies of new psychoactive substances? A study using MDMA, MDBD, butylone, MDPPP, MDPV, MDPB, 5-MAPB, and 5-API as examples
Keywords: LC-HR-MS/MS; Metabolism; Human liver preparation; HepaRG; HepG2; Methylenedioxy NPS;
Advantageous use of HepaRG cells for the screening and mechanistic study of drug-induced steatosis
Keywords: HepaRG; Steatosis; Screening; Drug
Hepatic differentiation of human pluripotent stem cells on human liver progenitor HepaRG-derived acellular matrix
Keywords: Extracellular matrix; Acellular matrix; Human embryonic stem cell; Human induced pluripotent stem cell; Hepatic differentiation; HepaRG
Interleukin 6 inhibits HBV entry through NTCP down regulation
Keywords: HBV; Hepatitis B virus; NTCP; Sodium taurocholate co-transporting polypeptide; IL-6; Interleukin 6; IFN γ; Interferon gamma; ALT; Alanine aminotransferase; TNFα; Tumor Necrosis Factor alpha; IL-1β; Interleukin 1 beta; OSM; Oncostatin M; PHH; Primary Hu
Metabolomics analysis of the toxicity pathways of triphenyl phosphate in HepaRG cells and comparison to oxidative stress mechanisms caused by acetaminophen
Keywords: HepaRG; Metabolomics; Hepatotoxicity; Acetaminophen; Triphenyl phosphate; Biomarker;
Two persistent organic pollutants which act through different xenosensors (alpha-endosulfan and 2,3,7,8 tetrachlorodibenzo-p-dioxin) interact in a mixture and downregulate multiple genes involved in human hepatocyte lipid and glucose metabolism
Keywords: Dioxin; Pesticides; HepaRG; Mixture; Metabolism; Microarray
Absence of in vitro genotoxicity potential of the mycotoxin deoxynivalenol in bacteria and in human TK6 and HepaRG cell lines
Keywords: ANOVA; analysis of variance; ANSES; French Agency for Food, Environmental and Occupational Health and Safety; BN; binucleated; CPA; cyclophosphamide; Cyt B; cytochalasin B; DMSO; dimethyl sulphoxide; DON; deoxynivalenol; EFSA; European Food Safety Authori
3D organotypic HepaRG cultures as in vitro model for acute and repeated dose toxicity studies
Keywords: In vitro models; Repeated dose toxicity; Chronic toxicity; HepaRG; Organotypic cultures;
Baseline and genotoxic compound induced gene expression profiles in HepG2 and HepaRG compared to primary human hepatocytes
Keywords: Primary human hepatocytes; HepaRG; HepG2; Gene expression; Interindividual variability;
The automated micronucleus assay for early assessment of genotoxicity in drug discovery
Keywords: Micronucleus; Cellular imaging; Flow cytometry; CHO; HepaRG; HepG2S9, Aroclor 1254 induced male Sprague-Dawley rat liver S9 fraction; % MN frequency, percentage micronucleus frequency; LOAEL, lowest observable adverse effect level; RCC, relative cell coun
Critical selection of reliable reference genes for gene expression study in the HepaRG cell line
Keywords: HepaRG; RT-qPCR; Reference gene; Normalization
Lactate is an ideal non-invasive marker for evaluating temporal alterations in cell stress and toxicity in repeat dose testing regimes
Keywords: Lactate; Oxidative stress; HepaRG; RPTEC/TERT1; BALB-3T3; Cell culture; Toxicity; Cell stress;
Research ArticleHepatitis B virus X protein is essential to initiate and maintain virus replication after infection
Keywords: HBV; hepatitis B virus; HBx; hepatitis B virus X protein; PHH; primary human hepatocytes; cccDNA; covalently closed circular DNA; ChIP; chromatin immunoprecipitation; Hepatitis B virus; HBx protein; Natural infection; Primary human hepatocytes; HepaRG;
HepaRG human hepatic cell line utility as a surrogate for primary human hepatocytes in drug metabolism assessment in vitro
Keywords: Hepatocyte characterization methods; Cytochrome P450; HepaRG; Intrinsic clearance; P450 enzyme induction; Primary human hepatocytes
Functional expression, inhibition and induction of CYP enzymes in HepaRG cells
Keywords: Cell culture; Hepatocyte; HepaRG; In vitro; Drug metabolism; Cytochrome P450CYP, cytochrome P450; FCS, fetal calf serum; IC50, concentration of inhibitor corresponding to a 50% decrease in reaction velocity compared to the control reaction; DMSO, dimethyl
Drug-metabolising enzymes are down-regulated by hypoxia in differentiated human hepatoma HepaRG cells: HIF-1α involvement in CYP3A4 repression
Keywords: Hypoxia; HIF-1α; Cytochrome P450; CYP3A4; Hepatocellular carcinoma; HepaRG; Chemoresistance;
CYP4A11 is repressed by retinoic acid in human liver cells
Keywords: Cytochrome P450; Retinoic acid; Human hepatoma cells; HepaRG; Fatty acid hydroxylase; LiverATRA, all-trans-retinoic acid; Bezaf, bezafibrate; 9-cis-RA, 9-cis-retinoic acid; CYP, cytochrome P450; FAS, fatty acid synthase; GAPDH, glyceraldehyde-3-phosphate