Adiponectin regulates AQP3 via PPARα in human hepatic stellate cells
Keywords: سلول‌های ستاره‌ای کبدی; Aquaporin; Hepatic stellate cells; Adiponectin; PPARα;
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Scoparone attenuates hepatic stellate cell activation through inhibiting TGF-β/Smad signaling pathway
Keywords: سلول‌های ستاره‌ای کبدی; Liver fibrosis; Hepatic stellate cells; Scoparone; Extracellular matrix;
99mTc-3PRGD2 scintigraphy to stage liver fibrosis and evaluate reversal after fibrotic stimulus withdrawn
Keywords: سلول‌های ستاره‌ای کبدی; Scintigraphy; 99mTc-3PRGD2; Integrin αvβ3; Liver fibrosis; Hepatic stellate cells;
Hepatic expression of cannabinoid receptors CB1 and CB2 correlate with fibrogenesis in patients with chronic hepatitis B
Keywords: سلول‌های ستاره‌ای کبدی; Cannabinoid receptor 1; Cannabinoid receptor 2; Hepatic stellate cells; Liver fibrosis; Chronic hepatitis B;
Silibinin induces hepatic stellate cell cycle arrest via enhancing p53/p27 and inhibiting Akt downstream signaling protein expression
Keywords: سلول‌های ستاره‌ای کبدی; silibinin; hepatic stellate cells; in vitro; cell cycle arrest; proliferation;
Saponins from the roots of Platycodon grandiflorum ameliorate high fat diet-induced non-alcoholic steatohepatitis
Keywords: سلول‌های ستاره‌ای کبدی; ACOX; acyl-CoA oxidase; ARE; antioxidant response element; CKS; Platycodon grandiflorum root-derived saponins; CPT-1; carnitine palmitoyltransferase-1; HFD; High fat diet; HSCs; hepatic stellate cells; NAFLD; non-alcoholic fatty liver disease; NASH; non-a
The HBx gene of hepatitis B virus can influence hepatic microenvironment via exosomes by transferring its mRNA and protein
Keywords: سلول‌های ستاره‌ای کبدی; PBS; phosphate buffer saline; EGFR; epidermal growth factor; αSMA; α smooth muscle actin; TGFβ; transforming growth factor β; col1a; collagen 1A; col3A; collagen 3A; MBP; maltose binding protein; BSA; bovine serum albumin; D2O; deuterium oxide; MTT; 3
MiR-142-3p blocks TGF-β-induced activation of hepatic stellate cells through targeting TGFβRI
Keywords: سلول‌های ستاره‌ای کبدی; miR-142-3p; TGF-β-Smad signaling pathway; TGFβRI; Hepatic stellate cells; Liver fibrosis;
Original ArticleAutophagy-deficient Kupffer cells promote tumorigenesis by enhancing mtROS-NF-κB-IL1α/β-dependent inflammation and fibrosis during the preneoplastic stage of hepatocarcinogenesis
Keywords: سلول‌های ستاره‌ای کبدی; Autophagy; Kupffer cells; Inflammation; Fibrosis; IL1; HCC; Hepatocellular carcinoma; CQ; Chloroquine; ROS; reactive oxygen species; KCs; Kupffer cells; HSCs; hepatic stellate cells; FBS; fetal bovine serum; DMEM; Dulbecco's modified Eagle's medium; LPS;
Innate immunity related pathogen recognition receptors and chronic hepatitis B infection
Keywords: سلول‌های ستاره‌ای کبدی; acLDL; acylated LDL; AIM2; absent in melanoma 2; AP-1; activator protein 1; BDCA-2; blood DC antigen; BEC; biliary epithelial cells; CARD; caspase recruitment and activation domains; cDC; common dendritic cells; CL-L1; collectin liver 1; CL-K1; collectin
Cytotherapy with M1-polarized macrophages ameliorates liver fibrosis by modulating immune microenvironment in mice
Keywords: سلول‌های ستاره‌ای کبدی; Liver fibrosis; Cytotherapy; Macrophages; Polarization; Hepatic stellate cells;
Tetrahydrocurcumin attenuates carbon tetrachloride-induced hepatic fibrogenesis by inhibiting the activation and autophagy of hepatic stellate cells
Keywords: سلول‌های ستاره‌ای کبدی; Tetrahydrocurcumin; Carbon tetrachloride; Fibrogenesis; Hepatic stellate cells; TGF-b1; Autophagy;
The orphan nuclear receptor COUP-TFII coordinates hypoxia-independent proangiogenic responses in hepatic stellate cells
Keywords: سلول‌های ستاره‌ای کبدی; Wound healing; Angiogenesis; HIF; NF-κB; Fibrosis; COUP transcription factor II; Hypoxia; Notch; Hepatic stellate cells; Cell transdifferentiation;
Hepatic stellate cell-targeted imatinib nanomedicine versus conventional imatinib: A novel strategy with potent efficacy in experimental liver fibrosis
Keywords: سلول‌های ستاره‌ای کبدی; Liver fibrosis; Hepatic stellate cells; Platelet derived growth factor; Vitamin A-coupled liposome; Targeted imatinib;
Potentiation of hepatic stellate cell activation by extracellular ATP is dependent on P2X7R-mediated NLRP3 inflammasome activation
Keywords: سلول‌های ستاره‌ای کبدی; ASC; apoptosis-associated speck-like protein containing CARD; ATP; adenosine 5â²-triphosphate; DAMP; danger-associated molecular patterns; ECM; excessive extracellular matrix; HSC; hepatic stellate cells; NLRP3; NOD-like receptor family pyrin domain cont
Autophagy regulates turnover of lipid droplets via ROS-dependent Rab25 activation in hepatic stellate cell
Keywords: سلول‌های ستاره‌ای کبدی; Autophagy; Lipid droplets; Hepatic stellate cells; ROS; Rab25;
Modulating angiogenesis with integrin-targeted nanomedicines
Keywords: سلول‌های ستاره‌ای کبدی; (RGD)m; RGD mimetics; 4-NQO; 4-nitroquinoline 1-oxide; AAA; Abdominal Aortic Aneurysms; ADA; 8-Amino-3,6-Dioxaoctonoic Acid; AH-GDM; Aminohexyl-Geldanamycin; ami; Amide; AP-2α; Activating Protein 2α; ARMS; Alveolar Rhabdomyosarcoma; ATO; Arsenic Trioxid
p16 deficiency promotes nonalcoholic steatohepatitis via regulation of hepatic oxidative stress
Keywords: سلول‌های ستاره‌ای کبدی; NASH; Oxidative stress; p16; DCF-DA; 2â², 7'-dichlorodihydrofluorescein diacetate; DMEM; Dulbecco's modified Eagle's medium; HSCs; hepatic stellate cells; MCD; methionine and choline-deficient; NASH; non-alcoholic steatohepatitis; PA; palmitic acid; RO
Hedgehog signaling inhibitor GANT61 induces endoplasmic reticulum stress-mediated protective autophagy in hepatic stellate cells
Keywords: سلول‌های ستاره‌ای کبدی; Hedgehog signaling; GANT61; Hepatic stellate cells; Autophagy; ER stress;
Caffeic acid phenethyl ester attenuates liver fibrosis via inhibition of TGF-β1/Smad3 pathway and induction of autophagy pathway
Keywords: سلول‌های ستاره‌ای کبدی; CAPE; Liver fibrosis; Hepatic stellate cells; TGF-β1/Smad3; Autophagy;
Hepatic stellate cell interferes with NK cell regulation of fibrogenesis via curcumin induced senescence of hepatic stellate cell
Keywords: سلول‌های ستاره‌ای کبدی; Hepatic fibrosis; Natural killer cell; Hepatic stellate cell; Senescence; Granule exocytosis; 3,4-DCI; 3,4-Dichloroisocoumarin; α-SMA; α-Smooth muscle actin; CCl4; Carbon tetrachloride; CMA; Concanamycin A; DAPI; 4â², 6-Diamidino-2-phenylindole; DMEM;
Scanning and transmission electron microscopy of the cells forming the hepatic sinusoidal wall of rat in acetaminophen- and Escherichia coli endotoxin-induced hepatotoxicity
Keywords: سلول‌های ستاره‌ای کبدی; acetaminophen; endothelial cell; endotoxin; hepatic stellate cells; Kupffer cell; sinusoidal wall;
Morin attenuates diethylnitrosamine-induced rat liver fibrosis and hepatic stellate cell activation by co-ordinated regulation of Hippo/Yap and TGF-β1/Smad signaling
Keywords: سلول‌های ستاره‌ای کبدی; Hepatic stellate cells; Hippo/Yap; TGF-β1/Smad; Morin; Fibrosis;
Recent advances in the design, development, and targeting mechanisms of polymeric micelles for delivery of siRNA in cancer therapy
Keywords: سلول‌های ستاره‌ای کبدی; AFM; atomic force microscopy; AMD; age-related macular degeneration; ANG; Angiopep-2; apoB; apolipoprotein B; ATP; adenosine triphosphate; AURKA; Aurora A kinase; BMA; butylmethacrylate; BPEI; branched PEI; BSA; bovine serum albumin; CCP; charge-conversio
LncRNA-ATB/microRNA-200a/β-catenin regulatory axis involved in the progression of HCV-related hepatic fibrosis
Keywords: سلول‌های ستاره‌ای کبدی; 3â²-UTR; 3â²-untranslated region; α-SMA; α-smooth muscle actin; ceRNA; competing endogenous RNA; CM; conditioned media; Col1A1; alpha-1 type I collagen; ECM; extracellular matrix; EMT; epithelial-mesenchymal transition; HCV; hepatitis C virus; HCC; he
A novel Golgi-Cox staining method for detecting and characterizing roles of the hepatic stellate cells in liver injury
Keywords: سلول‌های ستاره‌ای کبدی; Hepatic stellate cells; Golgi-Cox method; Morphology; CCl4; Liver cirrhosis; Rat;
3D in vitro models of liver fibrosis
Keywords: سلول‌های ستاره‌ای کبدی; HSCs; hepatic stellate cells; ALT; alanine aminotransferase; APAP; acetaminophen; AST; aminotransferase; CBDL; common biled duct ligation; DAMPs; damage associated molecular patterns; DCM; decellularized matrix; DILI; drug-induced liver injury; ECM; extra
Silencing of α-complex protein-2 reverses alcohol- and cytokine-induced fibrogenesis in hepatic stellate cells
Keywords: سلول‌های ستاره‌ای کبدی; Hepatic stellate cells; Primary HSC; Myofibroblast; Liver fibrosis; Poly (rC) binding protein (PCBP)2; Transforming growth factor(TGF)-β; Platelet-derived growth factor (PDGF); Epidermal growth factor (EGF); LY2a09761; Migration;
Astaxanthin inhibits inflammation and fibrosis in the liver and adipose tissue of mouse models of diet-induced obesity and nonalcoholic steatohepatitis
Keywords: سلول‌های ستاره‌ای کبدی; ACOX-1; acyl-coenzyme A oxidase 1; ALT; alanine aminotransferase; apoE; apolipoprotein E; Arg-1; arginase-1; ASTX; astaxanthin; Casp; caspase; CVD; cardiovascular disease; CPT-1α; carnitine palmitoyltransferase 1α; CD68; cluster of differentiation 68; C
MHC IIâ, but not MHC II+, hepatic Stellate cells contribute to liver fibrosis of mice in infection with Schistosoma japonicum
Keywords: سلول‌های ستاره‌ای کبدی; HSCs; hepatic stellate cells; FCM; flow cytometry; MHC II; major histocompatibility complex class II; α-SMA; alpha-smooth muscle actin; Col1α1; Collagen1α1; Timp1; tissue inhibitor of metalloproteinase-1; PD-L1; programmed death ligand 1; LRAT; lecithi
Hotair facilitates hepatic stellate cells activation and fibrogenesis in the liver
Keywords: سلول‌های ستاره‌ای کبدی; Hotair; LncRNA HOX transcript antisense RNA; HSCs; hepatic stellate cells; PRC2; polycomb repressive complex 2; H3K27me3; histone H3-lysine27; DNMT1; DNA methyltransferase 1; α-SMA; alpha smooth muscle actin; Col1a1; alpha1(1) collagen; NcRNA; non-coding
Hepatic stellate cells retain the capacity to synthesize retinyl esters and to store neutral lipids in small lipid droplets in the absence of LRAT
Keywords: سلول‌های ستاره‌ای کبدی; Hepatic stellate cells; LRAT; DGAT1; Retinyl esters; Lipid droplets; Lipidomics; ARAT; acyl coenzyme A:retinol acyltransferase; DGAT1; acyl-CoA:diacylglycerol acyltransferase 1; HSC; hepatic stellate cell; LRAT; lecithin:retinol acyltransferase; MRM; mult
Milk Fat Globule-EGF Factor 8, Secreted by Mesenchymal Stem Cells, Protects Against Liver Fibrosis in Mice
Keywords: سلول‌های ستاره‌ای کبدی; Mouse Model; Signal Transduction; MMP; Decorin; MSC; mesenchymal stem/stromal cell; ECM; extracellular matrix; TGF; transforming growth factor; HSCs; hepatic stellate cells; MMPs; matrix metalloproteinases; TIMPs; tissue inhibitors of metalloproteinases;
Adoptive transferred hepatic stellate cells attenuated drug-induced liver injury by modulating the rate of regulatory T cells/T helper 17 cells
Keywords: سلول‌های ستاره‌ای کبدی; Regulatory T cells; Tregs; Hepatic stellate cells; T helper 17 cells; Th17 cells
Tetrandrine induces lipid accumulation through blockade of autophagy in a hepatic stellate cell line
Keywords: سلول‌های ستاره‌ای کبدی; Hepatic stellate cells; Lipid droplet; Autophagy; Perilipin 1; Tetrandrine;
Involvement of miR-30c in hepatic stellate cell activation through the repression of plasminogen activator inhibitor-1
Keywords: سلول‌های ستاره‌ای کبدی; Hepatic fibrosis/cirrhosis; Hepatic stellate cells; miR-30c; Angiotensin II
Chebulic acid prevents hepatic fibrosis induced by advanced glycation end-products in LX-2 cell by modulating Nrf2 translocation via ERK pathway
Keywords: سلول‌های ستاره‌ای کبدی; T. chebula; Terminalia chebula Retz.; Glycer-AGEs; glyceraldehyde-derived advanced glycation end-products; NASH; nonalcoholic steatohepatitis; ROS; reactive oxygen species; ARE; antioxidant response element; Nrf2; nuclear factor E2-related factor 2; MAP k
Vitamin A and insulin are required for the maintenance of hepatic stellate cell quiescence
Keywords: سلول‌های ستاره‌ای کبدی; Hepatic stellate cells; Vitamin A; Insulin;
Inhibitory effects of Phyllanthus emblica L. on hepatic steatosis and liver fibrosis in vitro
Keywords: سلول‌های ستاره‌ای کبدی; α-SMA; alpha-smooth muscle actin; ACC; acetyl-CoA carboxylase; AMPK; AMP-activated protein kinase; CPT-1; carnitine palmitoyl transferase-1; EA; ellagic acid; FAS; fatty acid synthase; FFA; free fatty acid; HSCs; hepatic stellate cells; NAFLD; nonalcohol
Fibroblast growth factor 21 attenuates hepatic fibrogenesis through TGF-β/smad2/3 and NF-κB signaling pathways
Keywords: سلول‌های ستاره‌ای کبدی; Fibroblast growth factor 21; Hepatic fibrogenesis; Hepatic stellate cells; TGF-β; NF-κB;
PTP1B confers liver fibrosis by regulating the activation of hepatic stellate cells
Keywords: سلول‌های ستاره‌ای کبدی; HSCs; Hepatic stellate cells; PTP1B; Protein tyrosine phosphatase 1B; TGF-β1; Transforming growth factor-β1; MDI; Adipogenic differentiation mixture; ECM; Extracellular matrix; qHSCs; Quiescent HSCs; α-SMA; α-smooth muscle actin; col1α1; Type I colla
Effects of andrographolide on intrahepatic cholestasis induced by alpha-naphthylisothiocyanate in rats
Keywords: سلول‌های ستاره‌ای کبدی; Alpha-naphthylisothiocyanate (PubChem CID: 11080); Andrographolide (PubChem CID: 5318517); Carboxymethylcellulose Sodium (PubChem CID: 23706213)Cholestasis; Andrographolide; Alpha-naphthylisothiocyanate; Bile duct; Hepatic stellate cells; Bile acid transp
Localization of Xenobiotic Transporter OCTN1/SLC22A4 in Hepatic Stellate Cells and Its Protective Role in Liver Fibrosis
Keywords: سلول‌های ستاره‌ای کبدی; transporters; membrane transporter; organic cation transporters (OCT); antioxidants; induction; SLC; solute carrier; ECM; extracellular matrix; NPC; nonparenchymal cells; NASH; nonalcoholic steatohepatitis; HSCs; hepatic stellate cells; OCTN1; carnitine/o
Upregulation of SIRT1-AMPK by thymoquinone in hepatic stellate cells ameliorates liver injury
Keywords: سلول‌های ستاره‌ای کبدی; α-SMA; α-smooth muscle actin; AICAR; 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside; ALD; alcoholic liver disease; ALT; alanine aminotransferase; AMPK; AMP-activated protein kinase; AST; aspartate aminotransferase; HSCs; hepatic stellate cells; LK
ROS-JNK1/2-dependent activation of autophagy is required for the induction of anti-inflammatory effect of dihydroartemisinin in liver fibrosis
Keywords: سلول‌های ستاره‌ای کبدی; ALT; alanine aminotransferase; AST; aspartate aminotransferase; ALP; alkaline phosphatase; Atg; autophagy-related gene; α-SMA; alpha smooth muscle actin; Cat; catalase; DHA; dihydroartemisinin; ERK1/2; extracellular regulated kinase1/2; GSH; glutathione;
Intracellular trafficking and exocytosis of a multi-component siRNA nanocomplex
Keywords: سلول‌های ستاره‌ای کبدی; siRNA delivery; Nanocomplex; Hepatic stellate cells; Intracellular trafficking; Exocytosis
Research ArticleHepatic stellate cell transdifferentiation involves genome-wide remodeling of the DNA methylation landscape
Keywords: سلول‌های ستاره‌ای کبدی; 5-hmC; 5-hydroxymethylcytosine; 5-mC; 5-methylcytosine; aHSC; activated hepatic stellate cells; ALD; alcoholic liver disease; DNMT; DNA methyltransferase; HSC; hepatic stellate cells; MeCP2; methyl-CpG binding protein 2; NHL; normal human liver; PSC; prim
Integrins and integrin-related proteins in cardiac fibrosis
Keywords: سلول‌های ستاره‌ای کبدی; α-SMA; α-smooth muscle actin; Ang II; angiotensin II; CFs; cardiac fibroblasts; CM; cardiac myocyte; ED-A FN; ED-A fibronectin; EC; endothelial cells; EndMT; endothelial-mesenchymal transition; EMT; epithelial-mesenchymal transition; ECM; extracellu
Persistence of cirrhosis is maintained by intrahepatic regulatory T cells that inhibit fibrosis resolution by regulating the balance of tissue inhibitors of metalloproteinases and matrix metalloproteinases
Keywords: سلول‌های ستاره‌ای کبدی; α-SMA; α-smooth muscle actin; CCl4; carbon tetrachloride; CTL; cytotoxic lymphocyte; CTLA-4; cytotoxic T-lymphocyte-associated protein 4; DMEM; Dulbecco modified Eagle medium; ECM; extracellular matrix; FACS; fluorescence activated cell sorting; GITR;
Cyclooxygenase-2 contributes to the selective induction of cell death by the endocannabinoid 2-arachidonoyl glycerol in hepatic stellate cells
Keywords: سلول‌های ستاره‌ای کبدی; Cyclooxygenase-2; 2-Arachidonoyl glycerol; Prostaglandin D2 glycerol ester; Hepatic stellate cells; Hepatocytes; Cell death;