
Research ArticleIron overload in hereditary tyrosinemia type 1 induces liver injury through the Sp1/Tfr2/hepcidin axis
Keywords: HTI; hereditary tyrosinemia type I; Fah; fumarylacetoacetate hydrolase; Tfr2; transferrin receptor 2; HH; hereditary hemochromatosis; Hjv; hemojuvelin; NTBC; 2-(2-nitro-4-trifluoromethylbe -nzoyl)-1,3-cyclohexanedione; Fpn; ferroportin; Tfr1; transferrin