دانلود مقالات ISI درباره hERG، ژن وابسته به اتر-go-go انسان است + ترجمه فارسی

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Progress in computational toxicology

Keywords: hERG، ژن وابسته به اتر-go-go انسان است; ANN, artificial neural networks; BSEP, bile salt export pump; DILI, drug-induced liver injury; ECFC_6, extended connectivity functional class fingerprints of maximum diameter 6; hERG, human ether-a-go-go-related gene; HIAT, hepatocyte imaging assay techno

دانلود رایگان متن کامل مقاله ISI 26 صفحه سال انتشار : 2014 سفارش ترجمه

Proteolytic cleavage in the S1–S2 linker of the Kv1.5 channel does not affect channel function

Keywords: hERG، ژن وابسته به اتر-go-go انسان است; CHX, Cycloheximide; co-IP, Co-immunoprecipitation; hERG, Human ether-a-go-go-related gene; IKur, The ultra-rapidly activating delayed rectifier potassium current; PK, Proteinase KCell-surface protein; Electrophysiology; Kv1.5; Trafficking; Voltage-gated p

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Position of premature termination codons determines susceptibility of hERG mutations to nonsense-mediated mRNA decay in long QT syndrome

Keywords: hERG، ژن وابسته به اتر-go-go انسان است; CHX, cycloheximide; EJC, exon junction complex; hERG, human ether-a-go-go-related gene; HPH, hygromycin B phosphotransferase; LQT2, long QT syndrome type 2; MO, morpholino oligonucleotide; NMD, nonsense-mediated mRNA decay; nt, nucleotide; PTC, premature

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

RNA interference targeting E637K mutation rescues hERG channel currents and restores its kinetic properties

Keywords: hERG، ژن وابسته به اتر-go-go انسان است; hERG, human ether-a-go-go-related gene; IKr, rapidly activating delayed rectifier potassium current; LQTS, long QT syndrome; LQT2, long QT syndrome type 2; RNAi, RNA interference; siRNA, small interference RNA; V1/2, half-maximal voltage valueGene therapy

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Mephedrone, a new designer drug of abuse, produces acute hemodynamic effects in the rat

Keywords: hERG، ژن وابسته به اتر-go-go انسان است; CHO, Chinese hamster ovary; HERG, human ether-a-go-go-related gene; ANOVA, analysis of variance; ECG, electrocardiogram; LVIDD, left ventricular internal diameter in diastole; LVIDS, left ventricular internal diameter in systole; LVVD, left ventricular vo

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Impaired ion channel function related to a common KCNQ1 mutation — Implications for risk stratification in long QT syndrome 1

Keywords: hERG، ژن وابسته به اتر-go-go انسان است; ECG, electrocardiogram; hERG, human ether-a-go-go-related gene; ICD, implantable cardioverter defibrillator; LQTS, long QT syndrome; VSD, ventricular septal defect; WT, wild typeCardiac electrophysiology; IKs current; KCNQ1 (Kv7.1 KvLQT1); Long QT syndrom

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Torsades de pointes following acute myocardial infarction: Evidence for a deadly link with a common genetic variant

Keywords: hERG، ژن وابسته به اتر-go-go انسان است; Long QT syndrome; Cardiac arrhythmia; Sudden cardiac death; Molecular genetics; Single nucleotide polymorphismECG, electrocardiogram; HERG, human ether-a-go-go-related gene; IKr, delayed rectifier potassium current; LQTS, long QT syndrome; MI, myocardial

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Mechanisms underlying the protein-kinase mediated regulation of the HERG potassium channel synthesis

Keywords: hERG، ژن وابسته به اتر-go-go انسان است; HERG, human ether-a-go-go-related gene; HEK, human embryonic kidney; PKA, protein kinase A; PKC, protein kinase C; PMA, phorbol 12-myristate 13-acetate; CPT-cAMP, chlorophenylthiol-cyclic-AMP; H89, N-[2-(4-bromocinnamylamino)ethyl]-5-isoquinoline; Bis-I,

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

The selective estrogen receptor modulator raloxifene inhibits cardiac delayed rectifier potassium currents and voltage-gated sodium current without QTc interval prolongation

Keywords: hERG، ژن وابسته به اتر-go-go انسان است; hERG, human ether-a-go-go-related gene; ECG, electrocardiogramRaloxifene; Delayed rectifier potassium currents; Voltage-gated sodium current; QTc interval

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

Blockade of the IKs potassium channel: An overlooked cardiovascular liability in drug safety screening?

Keywords: hERG، ژن وابسته به اتر-go-go انسان است; APD, action potential duration; EAD, early after-depolarisation; hERG, human ether-a-go-go-related gene; HSD-1, 11β-hydroxysteroid dehydrogenase-1; IC50, 50% inhibitory concentration; IKr, rapidly activating delayed inward rectifier potassium channel; IKs

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2009 سفارش ترجمه

The fentanyl/etomidate-anaesthetised beagle (FEAB) dog: A versatile in vivo model in Cardiovascular Safety Research

Keywords: hERG، ژن وابسته به اتر-go-go انسان است; CHO, Chinese Hamster Ovary; DAD, delayed after depolarisations; EAD, early after depolarisations; FEAB, Fentanyl/Etomidate-Anaesthetised Beagle; HEK, Human Embryonic Kidney; hERG, human ether-a-go-go-related gene; HP-β-CD, hydroxypropyl-beta-cyclodextrin;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2009 سفارش ترجمه

Structures of sea anemone toxins

Keywords: hERG، ژن وابسته به اتر-go-go انسان است; Sea anemone; Toxin; Cytolysin; Protease inhibitor; Ion channel; NMR; CrystallographyAP-A, anthopleurin-A; AP-B, anthopleurin-B; CD, circular dichroism; EqtII, equinatoxin II; HERG, human ether-a-go-go-related gene; Kv, voltage-gated K+ channel; KCa, Ca2+-

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2009 سفارش ترجمه

Inhibition of cardiac HERG potassium channels by antidepressant maprotiline

Keywords: hERG، ژن وابسته به اتر-go-go انسان است; TdP, torsades de pointes; HERG, human ether-a-go-go-related gene; IKr, rapidly activating delayed rectifier potassium current; HEK-293, human embryonic kidney; LQTS, acquired long QT syndrome; MES, 4-morpholineethanesulfonic acid; G418, geneticinMaprotili

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2006 سفارش ترجمه

Human ether-a-go-go-related (HERG) gene and ATP-sensitive potassium channels as targets for adverse drug effects

Keywords: hERG، ژن وابسته به اتر-go-go انسان است; 6TM, 6 transmembrane helix; AP, action potential; APD, action potential duration; EAD, early afterdepolarization; ECG, electrocardiogram; HERG, human ether-a-go-go-related gene; IC50, half-maximally inhibitory concentration; IKr, cardiac rapidly activatin

دانلود رایگان متن کامل مقاله ISI 26 صفحه سال انتشار : 2006 سفارش ترجمه