Keywords: HIF، عامل القایی هیپوکسی; ADMA, asymmetric dimethylarginine; BALF, bronchoalveolar lavage fluid; Col, collagen; DAPI, 4′, 6-diamidino-2-phenylindole; DMEM, Dulbecco's Modified Eagle's Medium; ECM, extracellular matrix; HIF, hypoxia-inducible factor; HLF, human lung fibroblast; IPF
مقالات ISI HIF، عامل القایی هیپوکسی (ترجمه نشده)
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Keywords: HIF، عامل القایی هیپوکسی; EDTA, ethylenediaminetetraacetic acid; eNOS, endothelial nitric oxide synthase; GSH, reduced glutathione; Hb, hemoglobin; HIF, hypoxia-inducible factor; HK-II, hexokinase-2; HO-1, heme oxygenase 1; Hp, haptoglobin; HPAEC, human pulmonary artery endothelia
Keywords: HIF، عامل القایی هیپوکسی; BLI, bioluminescence imaging; CHX, cycloheximide; EGFP, enhanced green fluorescent protein; HIF, hypoxia-inducible factor; HRE, hypoxia-response element; Luc, luciferase; ODD, oxygen-dependent degradation domain; RFP, red fluorescent protein
Keywords: HIF، عامل القایی هیپوکسی; BMI, body mass index; ChREBP, carbohydrate-responsive element-binding protein; DCA, deoxycholic acid; DMBA, dimethylbenz(a)anthracene; HBV, hepatitis B virus; HCC, hepatocellular carcinoma; HCV, hepatitis C virus; HIF, hypoxia-inducible factor; IGF, insul
Keywords: HIF، عامل القایی هیپوکسی; αTAT, α-tubulin acetyltransferase; AurA, Aurora kinase A; CaM, Calmodulin; Cas, Crk-associated substrate; CK1, Casein kinase 1; Cnk2p, Chlamydomonas NIMA-related kinase 2; Dvl, Dishevelled; HDAC 6, Histone deacetylase 6; HIF, Hypoxia-inducible factor; IFT
Spectroscopic study on the formation of DNA-Ag clusters and its application in temperature sensitive vehicles of DOX
Keywords: HIF، عامل القایی هیپوکسی; DNA-AgNCs, DNA-Ag nanoclusters; Dox, doxorubicin; HIF, hypoxia-inducible factor; N-Pro, total protein from normal cell; H-Pro, total protein from HepG-2DNA-Ag cluster; Aptamer; Vehicle; Dox; Temperature
Regulation of fatty acid binding proteins by hypoxia inducible factors 1α and 2α in the placenta: Relevance to pre-eclampsia
Keywords: HIF، عامل القایی هیپوکسی; HIF, hypoxia-inducible factor; HRE, hypoxic response element; qPCR, quantitative real-time PCR; SDHA, succinate dehydrogenase complex, subunit APre-eclampsia; Hypoxia; Long chain polunsatured fatty acids; Placenta; Hypoxia-inducible factor-1 alpha; Fatty
Convergent evolution of SOCS4 between yak and Tibetan antelope in response to high-altitude stress
Keywords: HIF، عامل القایی هیپوکسی; SOCS4, suppressors of cytokine signaling 4; HIF, hypoxia-inducible factor; TA, Tibetan antelope; QTP, Qinghai–Tibet PlateauYak; Tibetan antelope; SOCS4; Convergent evolution; High-altitude adaptation
Pre-clinical evaluation of AZD-2014, a novel mTORC1/2 dual inhibitor, against renal cell carcinoma
Keywords: HIF، عامل القایی هیپوکسی; 3-MA, 3-methyladenine; ATG-5, autophagy protein 5; Cq, chloroquine; RAD001, everolimus; LC3B, light chain 3B; HIF, hypoxia-inducible factor; mTOR, mammalian target of rapamycin; MTT, methylthiazol tetrazolium; PI3K, phosphoinositide-3 kinase; PARP, poly (
Hypoxia inducible factor 1α down regulates cell surface expression of α1,2-fucosylated glycans in human pancreatic adenocarcinoma cells
Keywords: HIF، عامل القایی هیپوکسی; HIF, hypoxia-inducible factor; Ley, Lewis Y; Lex, Lewis X; BG, blood group; PDAC, pancreatic ductal adenocarcinoma; PC, pancreatic cancer; ARNT, arylhydrocarbon receptor nuclear transporter; UEA-1, Ulex europaeus agglutinin I; PaTu-S, Pa-Tu-8988S; PaTu-T,
The action of HIF-3α variants on HIF-2α–HIF-1β heterodimer formation is directly probed in live cells
Keywords: HIF، عامل القایی هیپوکسی; bHLH, basic helix-loop-helix; DFO, deferoxamine; FRET, fluorescence resonance energy transfer; HIF, hypoxia-inducible factor; IPAS, inhibitory PAS domain; ODDD, oxygen-dependent degradation domain; PAS, Per-ARNT-Sim; PHD, prolyl hydroxylase; TAD, transact
Functional regulation of hypoxia inducible factor-1α by SET9 lysine methyltransferase
Keywords: HIF، عامل القایی هیپوکسی; HIF, hypoxia-inducible factor; HRE, hypoxia response element; PHD, prolyl hydroxylase; VHL, von Hippel–Lindau; WCL, whole cell lysate; HK2, hexokinase 2; LDHA, lactate dehydrogenase A; PDK1, pyruvate dehydrogenase kinase, isozyme 1; ENO1, enolase 1; JMJD1
Hypoxia impairs anti-viral activity of natural killer (NK) cells but has little effect on anti-fibrotic NK cell functions in hepatitis C virus infection
Keywords: HIF، عامل القایی هیپوکسی; E:T ratio, effector:target ratio; FACS, fluorescence-activated cell sorting; HBV, hepatitis B virus; HCV, hepatitis C virus; HIF, hypoxia-inducible factor; HIV, human immunodeficiency virus; HSC, hepatic stellate cells; IFN, interferon; IL, interleukin; L
Gene expression alterations in chronic hypoxic MCF7 breast cancer cell line
Keywords: HIF، عامل القایی هیپوکسی; ADORA2B, Adenosine A2b receptor; BTG1, B-cell translocation gene 1, antiproliferative; Ct, Cycle threshold; DDIT4, DNA-damage-inducible transcript 4; HIF, Hypoxia-inducible factor; HNF4A, Hepatocyte nuclear factor 4, alpha; IC50, Half maximal inhibitory c
Differential roles of Sirt1 in HIF-1α and HIF-2α mediated hypoxic responses
Keywords: HIF، عامل القایی هیپوکسی; Ac-K, acetylated lysine residue; CAD, C-terminal transactivation domain; CBP, CREB-binding protein; DBD, DNA-binding domain; HDAC, histone deacetylase; HIF, hypoxia-inducible factor; PCAF, p300/CBP-associated factor; Sirt1, sirtuin 1Sirtuin 1; Lysine acet
MicroRNA regulation of cancer metabolism: role in tumour suppression
Keywords: HIF، عامل القایی هیپوکسی; ACL, ATP citrate lyase; CAT, catalase; CIV, complex IV; ECs, endothelial cells; ETC, electron transport chain; HIF, hypoxia-inducible factor; IDH, isocitrate dehydrogenase; IGF, insulin-like growth factor; IRS1, insulin receptor substrate-1; miRNA, microR
Role of hepatic resident and infiltrating macrophages in liver repair after acute injury
Keywords: HIF، عامل القایی هیپوکسی; APAP, acetaminophen; KCs, Kupffer cells; IMs, infiltrating macrophages; LSECs, liver sinusoidal endothelial cells; HIF, hypoxia-inducible factor; Macs, macrophages; AILI, acetaminophen (APAP)-induced liver injury; MCP-1, macrophage chemotactic protein-1;
Attenuation of the activated mammalian target of rapamycin pathway might be associated with renal function reserve by a low-protein diet in the rat remnant kidney model
Keywords: HIF، عامل القایی هیپوکسی; α-SMA, α-smooth muscle actin; CKD, chronic kidney diseases; ECM, extracellular matrix protein; HIF, hypoxia-inducible factor; mTOR, mammalian target of rapamycin; Nx-LPD, nephrectomized rats fed with a low-protein diet; Nx-NPD, nephrectomized rats fed wit
Mechanisms underlying helper T-cell plasticity: Implications for immune-mediated disease
Keywords: HIF، عامل القایی هیپوکسی; T-cell plasticity; asthma; allergic disease; epigenetics; histone modification; therapyBcl6, B-cell lymphoma 6; Foxp3, Forkhead box protein 3; HIF, Hypoxia-inducible factor; H3K4me3, Histone 3 lysine 4 trimethylation; H3K27me3, Histone 3 lysine 27 trimeth
Mitochondrial complex II, a novel target for anti-cancer agents
Keywords: HIF، عامل القایی هیپوکسی; BH3, Bcl-2 homology-3; 3BP, 3-bromopyruvate; CI, complex I; DCA, dichloroacetate; ETC., electron transport chain; HIF, hypoxia-inducible factor; MIM, mitochondrial inner membrane; MitoVES, mitochondrially targeted vitamin E succinate; MOM, mitochondrial o
Mechanisms, indications and results of salvage systemic therapy for sporadic and von Hippel–Lindau related hemangioblastomas of the central nervous system
Keywords: HIF، عامل القایی هیپوکسی; HB(s), hemangioblastoma(s); CNS, central nervous system; VHLvon Hippel–, Lindau; HIF, hypoxia-inducible factor; WHO, World Health Organization; MRI, magnetic resonance imaging; CT, computed tomography; CMO, cystoid macular edema; KPS, Karnofsky Performanc
Mitochondrial bioenergetic function and metabolic plasticity in stem cell differentiation and cellular reprogramming
Keywords: HIF، عامل القایی هیپوکسی; bFGF, basic fibroblast growth factor; Pol γ, DNA polymerase γ; ESC, embryonic stem cell; HIF, hypoxia-inducible factor; HSC, hematopoietic stem cell; iPSC, induced pluripotent stem cell; MSC, mesenchymal stem cell; mtDNA, mitochondrial DNA; mTOR, mammalia
Increased Expression of Adenosine Triphosphate-Sensitive K+ Channels in Mitral Dysfunction : Mechanically Stimulated Transcription and Hypoxia-Induced Protein Stability?
Keywords: HIF، عامل القایی هیپوکسی; ischemia; Kir6.2 expression; mechanical stress; mitral regurgitation; transcriptionFOX, forkhead box; HIF, hypoxia-inducible factor; KATP, adenosine triphosphate-sensitive potassium; Kir, potassium inward rectifier; LA, left atrium; LV, left ventricle; MR
Hypoxia-induced SM22α in A549 cells activates the IGF1R/PI3K/Akt pathway, conferring cellular resistance against chemo- and radiation therapy
Keywords: HIF، عامل القایی هیپوکسی; EGFR, epidermal growth factor receptor; HIF, hypoxia-inducible factor; IGFIR, type 1 insulin-like growth factor receptor; IgG, immunoglobulin G; MMP-9, metallomatrix protease-9; MMS, methyl methanesulfonate; NSCLC, non-small cell lung carcinoma; PI3K, phs
Molecular characterization and expression analysis of three hypoxia-inducible factor alpha subunits, HIF-1α/2α/3α of the hypoxia-sensitive freshwater species, Chinese sucker
Keywords: HIF، عامل القایی هیپوکسی; HIF, hypoxia-inducible factor; ODD, oxygen-dependent degradation; ARNT, aryl-hydrocarbon receptor nuclear translocator; PHD, prolyl hydroxylase; HRE, hypoxia response element; DO, dissolved oxygen; ORF, open reading frame; UTR, untranslated regionChinese
The control of the balance between ceramide and sphingosine-1-phosphate by sphingosine kinase: Oxidative stress and the seesaw of cell survival and death
Keywords: HIF، عامل القایی هیپوکسی; ABC, ATP-binding cassette; BH3, Bcl-2 homology-3; ER, endoplasmic reticulum (ER); ERK, extracellular signal-regulated kinase; HIF, hypoxia-inducible factor; JNK, c-jun N-terminal kinase; mTOR, mammalian target of rapamycin; N-SMase, neutral sphingomyelina
Portal hypertensive cardiovascular pathology: The rescue of ancestral survival mechanisms?
Keywords: HIF، عامل القایی هیپوکسی; CO, carbon monoxide; CTGF, connective tissue growth factor; HDL, high-density lipoproteins; HIF, hypoxia-inducible factor; IκB/NF-κB, inhibitor kappa B/nuclear factor-κB system; LBP, lipopolysaccharide binding protein; LDL, low density lipoproteins; MMP,
The Werner syndrome gene product (WRN): a repressor of hypoxia-inducible factor-1 activity
Keywords: HIF، عامل القایی هیپوکسی; ETC, Electron transport chain; GLUT-1, Glucose transporter-1; HIF, Hypoxia-inducible factor; HRE, Hypoxic response element; ODDD, Oxygen-dependent degradation domain; PHD, HIF prolyl-hydroxylase; pVHL, Von Hippel-Lindau tumor suppressor protein; ROS, Reac
Impaired hypoxic response in senescent mouse brain
Keywords: HIF، عامل القایی هیپوکسی; CA-IX, carbonic anhydrase 9; EPO, erythropoietin; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; GLUT1, glucose transporter-1; HIF, hypoxia-inducible factor; MCAO, middle cerebral artery occlusion; PHD, prolyl hydroxylase domain protein; RPS12, ribosoma
Hypoxia causes epigenetic gene regulation in macrophages by attenuating Jumonji histone demethylase activity
Keywords: HIF، عامل القایی هیپوکسی; JHDM, Jumonji histone demethylase; JMJD, Jumonji domain containing protein; ChIP, chromatin immunoprecipitation; PHD, prolyl hydroxylase; HIF, hypoxia-inducible factor; HRE, hypoxia-response element; NFκB, nuclear factor ‘kappa-light-chain-enhancer’ of ac
Metabolism, hypoxia and the diabetic heart
Keywords: HIF، عامل القایی هیپوکسی; HIF, hypoxia-inducible factor; FAT/CD36, fatty acid translocase; LCFACoA, long chain fatty acyl co-enzyme A; PPARα, peroxisome proliferator-activated receptor α; TAG, triacylglycerol; CPT1, carnitine palmitoyl transferase 1; GLUT, glucose transporter; HK,
Basic fibroblast growth factor regulates glucose metabolism through glucose transporter 1 induced by hypoxia-inducible factor-1α in adipocytes
Keywords: HIF، عامل القایی هیپوکسی; 2-NBDG, 2-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl) amino]-2-deoxy-d-glucose; BCA, bicinchonic acid; bFGF, basic fibroblast growth factor; ChIP, chromatin immunoprecipitation; DOC, sodium deoxycholate; GLUT, glucose transporter; HIF, hypoxia-inducible factor
PHD1 interacts with ATF4 and negatively regulates its transcriptional activity without prolyl hydroxylation
Keywords: HIF، عامل القایی هیپوکسی; ATF4, activating transcription factor 4; β-TrCP, β-transducin repeat-containing protein; FRET, fluorescence resonance energy transfer; GLUT-1, glucose transporter type 1; HIF, hypoxia-inducible factor; NAD, N-terminal activation domain; 2-OG, 2-oxoglutara
Studies on the Reaction of Nitric Oxide with the Hypoxia-Inducible Factor Prolyl Hydroxylase Domain 2 (EGLN1)
Keywords: HIF، عامل القایی هیپوکسی; nitric oxide; 2-oxoglutarate; hypoxia-inducible factor; oxygen-dependent degradation domain; prolyl hydroxylase domain-containing enzymePHD, prolyl hydroxylase domain-containing enzyme; HIF, hypoxia-inducible factor; 2OG, 2-oxoglutarate; CODD, C-terminal
Blood vessel maturation, vascular phenotype and angiogenic potential in malignant melanoma: One step forward for overcoming anti-angiogenic drug resistance?
Keywords: HIF، عامل القایی هیپوکسی; Melanoma; Angiogenesis; Pericytes; Vessel maturation; anti-Angiogenic therapyAng-2, angiopoietin-2; bFGF, basic fibroblast growth factor; Flt-1, VEGF receptor 1; Hif, hypoxia-inducible factor; IL-8, Interleukin-8; KDR, VEGF receptor 2; MMP, matrix metallo
The emerging role of nuclear factor kappa B in renal cell carcinoma
Keywords: HIF، عامل القایی هیپوکسی; EMT, epithelial–mesenchymal-transition; HIF, hypoxia-inducible factor; IκB, inhibitor of kappa B; IKK, inhibitor of kappa kinase; MDR, multidrug resistance; NF-κB, nuclear factor kappa B; PDTC, pyrrolidine dithiocarbamate; RCC, renal cell carcinoma; RHD,
The impact of MYC expression in lymphoma biology: Beyond Burkitt lymphoma
Keywords: HIF، عامل القایی هیپوکسی; BL, Burkitt lymphoma; CHOP, cyclophosphamide, hydroxydaunomycin, vincristine (Oncovin), prednisone; DLBCL, diffuse large B-cell lymphoma; FISH, fluorescence in situ hybridization; FL, follicular lymphoma; HIF, hypoxia-inducible factor; IG, immunoglobulin;
Improved transplantation outcome by epigenetic changes
Keywords: HIF، عامل القایی هیپوکسی; BMT, Bone marrow transplantation; CGI, CpG island; DC, Dendritic cell; DNMT, DNA methyltransferase; GVHD, Graft-versus-host-disease; GVL, Graft-versus-leukemia effect; HDAC, Histone deacetylase; HIF, Hypoxia-inducible factor; IDO, Indoleamine 2,3-dioxygen
Hypoxia-inducible factor 1-mediated regulation of PPP1R3C promotes glycogen accumulation in human MCF-7 cells under hypoxia
Keywords: HIF، عامل القایی هیپوکسی; HRE, hypoxia response element; HIF, hypoxia-inducible factor; PPP1R3C, protein phosphatase 1, regulatory subunit 3C; DFOM, deferoxamine mesylate salt; PHD2, prolyl hydroxylase domain protein 2; VHL, von Hippel–Lindau tumor suppressor protein; PTG, protein
Altered sphingolipid metabolism induced by tumor hypoxia – New vistas in glycolipid tumor markers
Keywords: HIF، عامل القایی هیپوکسی; CerS, ceramide synthase; CMH, ceramide monohexose; DHCer, Dihydroceramide; DHCMH, dihydroceramide monohexose; DHSph, dihydrosphingomyelin; HIF, hypoxia-inducible factor; HPLC–ESI-MS/MS, high-performance liquid chromatography-electrospray ionization-tandem
Thioredoxin-interacting protein inhibits hypoxia-inducible factor transcriptional activity
Keywords: HIF، عامل القایی هیپوکسی; BPD, bronchopulmonary dysplasia; Txnip, thioredoxin-interacting protein; Trx1, thioredoxin-1; HIF, hypoxia-inducible factor; HRE, hypoxia response element; pVHL, von Hippel-Lindau protein; VEGF, vascular endothelial growth factorThioredoxin-1; Thioredoxin
Oncostatin M up-regulates the ER chaperone Grp78/BiP in liver cells
Keywords: HIF، عامل القایی هیپوکسی; Erk, extracellular signal-regulated kinase; Grp, glucose-regulated protein; HIF, hypoxia-inducible factor; IFN, interferon; IL, interleukin; Jak, Janus kinase; MAPK, mitogen-activated kinase; OSM, oncostatin M; STAT, signal transducer and activator of tra
The expression of erythropoietin triggered by Danggui Buxue Tang, a Chinese herbal decoction prepared from Radix Astragali and Radix Angelicae Sinensis, is mediated by the hypoxia-inducible factor in cultured HEK293T cells
Keywords: HIF، عامل القایی هیپوکسی; DBT, Danggui Buxue Tang; RA, Radix Astragali; RAS, Radix Angelicae Sinensis; TCM, traditional Chinese medicine; EPO, erythropoietin; HRE, hypoxia response element; HIF, hypoxia-inducible factor; MAPK, mitogen-activated protein kinase; ERK, extracellular s
Cancer stem cells at the crossroads of current cancer therapy failures—Radiation oncology perspective
Keywords: HIF، عامل القایی هیپوکسی; CSC, cancer stem cell; HIF, hypoxia-inducible factor; TD50, transplantation dose 50%; TCD50, tumour control dose 50%; EGFR, epidermal growth factor receptor; VEGFR, vascular growth factor receptorBiomarker; Cancer stem cells; Local tumour control; Molecul
Liprin-α4 is a new hypoxia-inducible target gene required for maintenance of cell–cell contacts
Keywords: HIF، عامل القایی هیپوکسی; ChIP, chromatin immunoprecipitation; DP, 2,2'dipyridyl; HIF, hypoxia-inducible factor; HRE, HIF-responsive elements; HBS, HIF binding sites; LH, liprin homology domain; PHD, prolylhydroxylase; RCC, clear cell renal cell carcinoma; VHL, von Hippel-LindauLi
Uncoupling protein-2 and cancer
Keywords: HIF، عامل القایی هیپوکسی; Δψm, mitochondrial membrane potential; HIF, hypoxia-inducible factor; JNK, c-Jun N (amino)-terminal kinase; LMF, lipid mobilizing factor; LPS, lipopolysaccharide; NF-κB, nuclear factor κB; PGC-1α, peroxisome proliferator-activated receptor γ co-activator
Human PRP19 interacts with prolyl-hydroxylase PHD3 and inhibits cell death in hypoxia
Keywords: HIF، عامل القایی هیپوکسی; PHD, prolyl-hydroxylase domain containing; HIF, hypoxia-inducible factor; VHL, von Hippel Lindau; IgG, immunoglobulin G; Morg, MAPK organizer; FRET, fluorescence resonance energy transfer; BSA, bovine serum albumin; GFP, green fluorescent protein; hPRP19,
A cytoplasmic prolyl hydroxylation and glycosylation pathway modifies Skp1 and regulates O2-dependent development in Dictyostelium
Keywords: HIF، عامل القایی هیپوکسی; CAZy, carbohydrate active enzyme database; FucT, fucosyltransferase; GalT, galactosyltransferase; GT, glycosyltransferase; HIF, hypoxia-inducible factor; HyPro, hydroxyproline; PHD, prolyl hydroxylase domain; ROS, reactive oxygen species; SCF, protein com
HIF-1 in the inflammatory microenvironment
Keywords: HIF، عامل القایی هیپوکسی; DC, dendritic cell; FIH, factor inhibiting HIF; GLUT, glucose transporter; HIF, hypoxia-inducible factor; HRE, hypoxia-response element; IL, interleukin; IkB, inhibitor of kappa B; LPS, lipopolysaccharides; MAPK, mitogen-activated protein kinase; NF-κB, n
Differences in hydroxylation and binding of Notch and HIF-1α demonstrate substrate selectivity for factor inhibiting HIF-1 (FIH-1)
Keywords: HIF، عامل القایی هیپوکسی; ANK, ankyrin repeat domain; C-TAD, C-terminal trans-activation domain; FIH-1, factor inhibiting HIF-1; FP, fluorescence polarisation; h, human; HIF, hypoxia-inducible factor; HIF-α, hypoxia-inducible factor α subunit; HIF-P4H, HIF prolyl 4-hydroxylase; OD