Design of in vitro skin permeation studies according to the EMA guideline on quality of transdermal patches
Keywords: Ct; drug concentration at the same time point; D-plaster; diclofenac epolamine-loaded plaster; ESI; electron spray ionization; GMR; geometric Mean Ratio; HVDP; highly variable drugs or drug products; J; maximal permeation flux; Jtot; permeation flux calcu