Keywords: HIPK2; Notch; phosphate niclosamide; renal fibrosis; Smad; Wnt/β-catenin;
مقالات ISI (ترجمه نشده)
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Central role of dysregulation of TGF-β/Smad in CKD progression and potential targets of its treatment
Keywords: ACE2; angiotensin-converting enzyme-2; AGE; advanced glycation end-product; AT1R; angiotensin type 1 receptor; BMP; bone morphogenetic proteins; BMP-7; bone morphogenetic protein 7; CKD; chronic kidney diseases; Co-Smads; common mediator Smads; ECM; extra
HIPK2 polymorphisms rs2058265, rs6464214, and rs7456421 were associated with kidney stone disease in Chinese males not females
Keywords: HIPK2; homeo-domain interacting protein kinase 2; KSD; kidney stone disease; SBP; systolic blood pressure; Cr; creatinine; UA; uric acid; Ur; urea; TC(CHOL); cholesterol; TG; triglycerides; RTECs; renal tubular epithelial cells; KSD; HIPK2 gene; Polymorph
CNOT2 promotes proliferation and angiogenesis via VEGF signaling in MDA-MB-231 breast cancer cells
Keywords: CNOT2; Breast cancer; Tissue array; CAM; VEGF; CCR4-Not complex; carbon catabolite repressed 4-negative on TATA-less complex; EGFR; epidermal growth factor receptor; HER2; human epidermal growth factor receptor 2; TNBC; triple negative breast cancers; VEG
The interactions of p53 with tau and AÃ as potential therapeutic targets for Alzheimer's disease
Keywords: AD; Alzheimer's disease; AICD; amyloid precursor protein intracellular domain; Aβ; amyloid β peptides; ApoE; apolipoprotein E; APP; amyloid precursor proteins; BACE1; β-site APP cleaving enzyme 1; BIN1; bridging integrator 1; CBP; CREB-binding protei
Mini-reviewThe role of the NORE1A tumor suppressor in Oncogene-Induced Senescence
Keywords: RASSF; HIPK2; PP1A; Retinoblastoma; p53; Ras; OIS; Oncogene-Induced Senescence; NORE1A; Novel Ras Effector 1A; Rb; Retinoblastoma Protein; PTM; Post-Translational Modification; EGFR; Epidermal Growth Factor Receptor; NF1; Neurofibromin 1; DAB2IP; DAB2 Int
The inducible E3 ubiquitin ligases SIAH1 and SIAH2 perform critical roles in breast and prostate cancers
Keywords: Cytokine; Estrogen; Sex hormone; SIAH1; SIAH2; ACK1/TNK2; activated CDC42-associated kinase 1; AR; androgen receptor; ATM; ataxia telangiectasia mutated; ATR; ataxia telangiectasia mutated related; BF; biochemical failure; DCC; deleted in colorectal cance
Complex regulation of CREB-binding protein by homeodomain-interacting protein kinase 2
Keywords: BDNF; brain-derived neurotrophic factor; CBP; CREB-binding protein; C/EBP; CCAAT/enhancer binding protein; CRD1; cell cycle regulatory domain 1; CREB; cAMP-response element binding protein; CtBP; C-terminal-binding protein; DYRK; dual-specificity tyrosine
Programmed cell death 4 protein (Pdcd4) and homeodomain-interacting protein kinase 2 (Hipk2) antagonistically control translation of Hipk2 mRNA
Keywords: Pdcd4; Hipk2; HIPK1; Translation; Autoregulation;
Role of HIPK2 in kidney fibrosis
Keywords: cell signaling; HIPK2; kidney fibrosis; tubular epithelial cell
Crystal structures of human CtBP in complex with substrate MTOB reveal active site features useful for inhibitor design
Keywords: CtBP; C-terminal Binding Protein; MTOB; 4-Methylthio 2-oxobutyric acid; d2-HDH; d-isomer specific 2-hydroxyacid dehydrogenases; GRHPR; glyoxylate reductase/hydroxypyruvate reductase; PHGDH; phosphoglycerate dehydrogenase; NAD; nicotinamide adenine dinucle
SIRT1 negatively regulates the protein stability of HIPK2
Keywords: SIRT1; HIPK2; Deacetylation; Ubiquitination; Proteasomal degradation;
HIF1 regulates WSB-1 expression to promote hypoxia-induced chemoresistance in hepatocellular carcinoma cells
Keywords: Hypoxia; HIF-1; WSB-1; HIPK2; Chemoresistance;
Nemo-like kinase, a multifaceted cell signaling regulator
Keywords: NLK; Nemo-like kinase; IL-6; intereukin-6; MAPK; mitogen activated protein kinase; ERK; extracellular-signal regulated kinase; Pro; proline; Ser; serine; Thr; threonine; C. elegans; Caenorhabditis elegans; POP-1; Posterior pharynx defect protein 1; LEF1;
HIPK2 catalytic activity and subcellular localization are regulated by activation-loop Y354 autophosphorylation
Keywords: e.v.; empty vector; IF; immunofluorescence; IP; immunoprecipitation; IVT; in vitro translation; moAb; monoclonal antibody; purvA; purvalanol A; TCE; total cell extracts; WB; Western blotting; HIPK2; Posttranslational modification; Phosphorylation; Activat
The SxxSS motif of T-cell factor-4 isoforms modulates Wnt/β-catenin signal activation in hepatocellular carcinoma cells
Keywords: TCF-4; HCC; Wnt; HIPK2
SIAH-mediated ubiquitination and degradation of acetyl-transferases regulate the p53 response and protein acetylation
Keywords: SIAH; Ubiquitin E3 ligase; p53; Protein acetylation; HIPK2
Control of nuclear HIPK2 localization and function by a SUMO interaction motif
Keywords: SIM; SUMO; HIPK2; Nuclear bodies; PML;
Homeodomain-interacting protein kinase 2 (HIPK2) targets β-catenin for phosphorylation and proteasomal degradation
Keywords: HIPK2; β-Catenin phosphorylation; Proteasomal degradation
MiR-27a modulates MDR1/P-glycoprotein expression by targeting HIPK2 in human ovarian cancer cells
Keywords: miR-27a; Drug resistance; HIPK2; Ovarian cancer
Hypoxia suppresses chemotherapeutic drug-induced p53 Serine 46 phosphorylation by triggering HIPK2 degradation
Keywords: Hypoxia; Drug resistance; Adriamycin; p53; Siah1; HIPK2
Counteracting MDM2-induced HIPK2 downregulation restores HIPK2/p53 apoptotic signaling in cancer cells
Keywords: HIPK2; p53 transcriptional activity; Zinc supplementation; Apoptosis; MDM2
Pancreatic and duodenal homeobox 1 (PDX1) phosphorylation at serine-269 is HIPK2-dependent and affects PDX1 subnuclear localization
Keywords: PDX1; Islet; β-Cell; Phosphorylation; Glucose; HIPK2;
Egr-1 and Hipk2 are required for the TrkA to p75NTR switch that occurs downstream of IGF1-R
Keywords: Aging; Alzheimer's disease; Egr-1; Hipk2; IGF1-R; p75NTR; TrkA
Restoring wtp53 activity in HIPK2 depleted MCF7 cells by modulating metallothionein and zinc
Keywords: HIPK2; p53 conformation; Metallothioneins; MT2A; Zinc; Adriamycin; Conditional-RNA interference; Breast cancer; Combined chemotherapy
Transcriptional regulation of hypoxia-inducible factor 1α by HIPK2 suggests a novel mechanism to restrain tumor growth
Keywords: HIF-1α mRNA; HIF-1α promoter; ChIP; HIPK2; Luciferase activity; RNA interference
Overexpression of HIPK2 circumvents the blockade of apoptosis in chemoresistant ovarian cancer cells
Keywords: HIPK2; p53; Ovarian cancer; Chemotherapeutic drugs; Apoptosis; Caspase activity
Inhibitory effects of homeodomain-interacting protein kinase 2 on the aorta–gonad–mesonephros hematopoiesis
Keywords: Hematopoiesis; AGM region; HIPK2; Development
Novel interaction between HMGA1a and StIP1 in murine terminally differentiated retina
Keywords: HMGA1a; StIP1; STAT3; HIPK2; Retina;
Covalent modification of human homeodomain interacting protein kinase 2 by SUMO-1 at lysine 25 affects its stability
Keywords: HIPK2; SUMO-1; Ubc9; p53;
HIPK2 inhibits both MDM2 gene and protein by, respectively, p53-dependent and independent regulations
Keywords: HIPK2; p53; Phosphorylation; Proteasomal degradation; MDM2; Nuclear export
Smads and chromatin modulation
Keywords: AER; apical ectodermal ridge; ACF; ATP-utilizing chromatin assembly and remodeling factor; AML; acute myeloid leukaemia; AMT; arginine methyl transferase; ARC; activator-recruited cofactor; BAF; BRG1/hBRM-associated factors; BMP; bone morphogenic protein;