Keywords: آنتاگونیست های گیرنده هیستامین; GERD; gastroesophageal reflux disease; NERD; non-erosive disease; ERD; erosive disease; LES; lower esophageal sphincter; PPI; proton pump inhibitor; H2RA; histamine receptor antagonists; ATPase; adenosine 5â²triphosphatase; EE; erosive esophagitis; NNT;