
Keywords: HBOCs; Hemoglobin (Hb)-based oxygen carriers; HLL; Hb loaded nanoliposome; HIF-1α; hypoxia-inducible factors 1α subunits; VEGF; vascular endothelial growth factor; RBC; red blood cell; PEG-Hb; poly (ethyleneglycol)-conjugated Hb; LEH; liposome encapsula