Keywords: HLM، میکروزوم های کبدی انسان; AADAC, arylacetamide deacetylase; CES, carboxylesterase; CYP, cytochrome P450; DMSO, dimethyl sulfoxide; HIM, human intestinal microsomes; HJM, human jejunum microsomes; HLM, human liver microsomes; HPLC, high-performance liquid chromatography; NAT, N-ace
مقالات ISI HLM، میکروزوم های کبدی انسان (ترجمه نشده)
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Keywords: HLM، میکروزوم های کبدی انسان; CYP450, cytochrome P450; HLM, human liver microsomes; MLM, mouse liver microsomes; GEF, gefitinib; KCZ, ketoconazole; CPT, cisplatin; KCN, potassium cyanide; ILD, interstitial lung disease; GSH, glutathione; OPLS-DA, orthogonal projection to latent struct
Keywords: HLM، میکروزوم های کبدی انسان; CYP, cytochrome P450; DDI, drug–drug interactions; DPM, disintegrations per minute; HCV, hepatitis C virus; HLM, human liver microsomes; PBPK, Physiologically-based pharmacokinetics; PK, pharmacokinetics; TDI, time-dependent inhibitorCL, clearance; Drug–d
Selective 5-HT2C receptor agonists: Design and synthesis of pyridazine-fused azepines
Keywords: HLM، میکروزوم های کبدی انسان; ADME, absorption, distribution, metabolism, and excretion; CHO, Chinese hamster ovary; CNS, central nervous system; ER, efflux ratio; FLIPR, fluorescence imaging plate reader; HLM, human liver microsomes; MDCK, Madin–Darby Canine Kidney cell line; MDR-1,
Metabolic studies of prostanozol with the uPA-SCID chimeric mouse model and human liver microsomes
Keywords: HLM، میکروزوم های کبدی انسان; AAS, anabolic androgenic steroids; CEVAC, center for vaccinology; EIC, extracted ion chromatogram; GC–MS, gas chromatography–mass spectrometry; HAc, acetic acid; HLM, human liver microsomes; IS, internal standard; LC–MS/MS, liquid chromatography–tandem ma
Characterizing novel metabolic pathways of melatonin receptor agonist agomelatine using metabolomic approaches
Keywords: HLM، میکروزوم های کبدی انسان; CYP450, cytochrome P450; HLM, human liver microsomes; AGM, agomelatine; KCZ, ketoconazole; NF, α-naphthoflavone; GSH, reduced glutathione; NAc, N-acetyl cysteine; OPLS-DA, orthogonal projection to latent structures-discriminant analysis; UHPLC, ultra-high
Underlying mechanism of drug–drug interaction between pioglitazone and gemfibrozil: Gemfibrozil acyl-glucuronide is a mechanism-based inhibitor of CYP2C8
Keywords: HLM، میکروزوم های کبدی انسان; Gemfibrozil; Pioglitazone; Mechanism-based inhibition; Acyl-glucuronide; CYP2C8UGT, UDP-glucuronosyltransferase; HPLC, high performance liquid chromatography; CYP, cytochrome P450; AUC, area under the concentration/time curve; HLM, human liver microsomes;
Glucuronidation of estrone and 16α-hydroxyestrone by human UGT enzymes: The key roles of UGT1A10 and UGT2B7
Keywords: HLM، میکروزوم های کبدی انسان; 16α-OHE1, 16α-hydroxyestrone; E1, estrone; E2, 17β-estradiol; HIM, human intestine microsomes; HLM, human liver microsomes; UDPGA, uridine 5′-diphosphoglucuronic acid; UGT, UDP-glucuronosyltransferaseEstrone glucuronidation; UGT1A10; 16α-Hydroxyestrone co
Inhibition of in vitro metabolism of testosterone in human, dog and horse liver microsomes to investigate species differences
Keywords: HLM، میکروزوم های کبدی انسان; CYPs, cytochrome P450 enzymes; DMSO, dimethyl-sulphoxide; OH-TES, hydroxytestosterone; 17β HSD type 2, hydroxysteroid (17β) dehydrogenase 2; hLM, human liver microsomes; cLM, canine liver microsomes; eLM, equine liver microsomes; NADPH, nicotinamide adeni
In vitro modulatory effects of Terminalia arjuna, arjunic acid, arjunetin and arjungenin on CYP3A4, CYP2D6 and CYP2C9 enzyme activity in human liver microsomes
Keywords: HLM، میکروزوم های کبدی انسان; CYP, cytochrome P450; DMSO, dimethyl sulfoxide; HDI, herb–drug interactions; HLM, human liver microsomes; NADPH, nicotinamide adenine dinucleotide phosphate reduced tetrasodium saltCYP enzyme; Terminalia arjuna; Human liver microsomes; CYP inhibition; Her
Multidimensional LC–MS/MS analysis of liver proteins in rat, mouse and human microsomal and S9 fractions
Keywords: HLM، میکروزوم های کبدی انسان; CATWAX, mixed-bed weak cation/weak anion exchange; FDR, false discovery rate; GO, gene ontology; HILIC, hydrophilic interaction chromatography; HLM, human liver microsomes; HLS, human liver S9 fraction; HRMS, high-resolution mass spectrometry; IDA, inform
Investigating the contribution of CYP2J2 to ritonavir metabolism in vitro and in vivo
Keywords: HLM، میکروزوم های کبدی انسان; CYP2J2; CYP2D6; CYP3A4; Time dependent inhibition; Ritonavir; In vivo; SimcypAUC, area under the plasma concentration–time curve; CYP, cytochrome P450 monooxygenase; EM, extensive metabolizer; IM, intermediate metabolizer; HLM, human liver microsomes; PM,
Ginsenoside-mediated blockade of 1α,25-dihydroxyvitamin D3 inactivation in human liver and intestine in vitro
Keywords: HLM، میکروزوم های کبدی انسان; 1α,25(OH)2D3, 1α,25-dihydroxyvitamin D3; aPPD, 20(S)-protopanaxadiol; aPPT, 20(S)-protopanaxatriol; CYP, cytochrome P450; VDR, vitamin D receptor; LC–MS/MS, liquid chromatography–tandem mass spectrometry; HLM, human liver microsomes; HIM, human intestinal
Bio-generation of stable isotope labeled internal standards for absolute and relative quantitation of drug metabolites in plasma samples by LC–MS/MS
Keywords: HLM، میکروزوم های کبدی انسان; ACN, acetonitrile; % CV, coefficient of variation; DMSO, dimethyl sulfoxide; FDA, Food and Drug Administration; HLM, human liver microsomes; ICH, International Conference on Harmonization; IS, internal standard; LC, liquid chromatography; LLOQ, low limit
Mechanism-based CYP2D6 inactivation by acridone alkaloids of Indonesian medicinal plant Lunasia amara
Keywords: HLM، میکروزوم های کبدی انسان; CYP, cytochrome P450; NADP+, nicotinamide adenine dinucleotide phosphate; G-6-P, glucose-6-phosphate; GSH, N-acetyl-l-cysteine and glutathione reduced; HLM, human liver microsomes; TLC, thin layer chromatography; kinact, inactivation rate constant at infi
The contribution of human small intestine to chlorpyrifos biotransformation
Keywords: HLM، میکروزوم های کبدی انسان; 2β-OH, 2β-hydroxy testosterone; 6β-OH, 6β-hydroxy testosterone; CaE, carboxylesterase; CLi, intrinsic clearance; CYP, cytochrome P450 isoforms; CPF, chlorpyrifos; CPFO, chlorpyrifos-oxon; HDM, human duodenum microsomes; HLM, human liver microsomes; HS2M,
Highly variable pH effects on the interaction of diclofenac and indomethacin with human UDP-glucuronosyltransferases
Keywords: HLM، میکروزوم های کبدی انسان; 4-MU, 4-methylumbelliferone; ACN, acetonitrile; DMSO, dimethyl sulfoxide; HIM, human intestinal microsomes; HLM, human liver microsomes; LC, liquid chromatography; LC–MS, LC coupled to mass spectrometry; NSAIDs, non-steroidal anti-inflammatory drugs; UDPG
Potential implication of aniline derivatives in the Toxic Oil Syndrome (TOS)
Keywords: HLM، میکروزوم های کبدی انسان; dPAP, di-O-acyl derivative of PAP; EMS, Eosinophilia-Myalgia Syndrome; hPL, human pancreatic lipase; HLM, human liver microsomes; PAP, -(N-phenylamino)propane-1,2-diol; mPAP, mono-O-acyl derivative of PAP; OA, oleanilide; OPAP, monooleylester of PAP; OOPA
Metabolism related toxicity of diclofenac in yeast as model system
Keywords: HLM، میکروزوم های کبدی انسان; GSH, glutathione; HLM, human liver microsomes; NSAID, nonsteroidal anti-inflammatory drug; P450, cytochrome P450; ROS, reactive oxygen speciesDiclofenac; Yeast; Cytochrome P450; Oxidative metabolism; Reactive oxygen species
Liquid chromatography–tandem mass spectrometry method for measurement of nicotine N-glucuronide: A marker for human UGT2B10 inhibition
Keywords: HLM، میکروزوم های کبدی انسان; HLM, human liver microsomes; CID, collision induced dissociation; SRM, selected reaction monitoring; HPLC, high performance liquid chromatographyNicotine N-glucuronide; UGT2B10; LC–MS–MS
Handling reactive metabolite positives in drug discovery: What has retrospective structure–toxicity analyses taught us?
Keywords: HLM، میکروزوم های کبدی انسان; Rm, reactive metabolite; IADR, idiosyncratic adverse drug reaction; CYP, cytochrome P450; GSH, glutathione; NSAID, nonsteroidal anti-inflammatory drug; NAT 2, N-acetyltransferase 2; HLM, human liver microsomes; PK/PD, pharmacokinetic/pharmacodynamicDrug;
Development and validation of a rapid and sensitive assay for simultaneous quantification of midazolam, 1′-hydroxymidazolam, and 4-hydroxymidazolam by liquid chromatography coupled to tandem mass-spectrometry
Keywords: HLM، میکروزوم های کبدی انسان; P450, cytochrome P450 (also termed heme-thiolate P450); HLM, human liver microsomes; HPLC, high performance liquid chromatography; GC, gas chromatography; GC/MS, gas chromatography–mass spectrometry; LC–MS/MS, liquid chromatography–tandem mass-spectrometr
Effects of monoamine oxidase inhibitor and cytochrome P450 2D6 status on 5-methoxy-N,N-dimethyltryptamine metabolism and pharmacokinetics
Keywords: HLM، میکروزوم های کبدی انسان; CYP2D6, cytochrome P450 2D6; 5-MeO-DMT, 5-methoxy-N,N-dimethyltryptamine; MAOI, monoamine oxidase inhibitor; DDI, drug–drug interactions; EM, extensive metabolizer; PM, poor metabolizer; HLM, human liver microsomes; HPLC, high performance liquid chromatog
Determination and identification of estrogenic compounds generated with biosynthetic enzymes using hyphenated screening assays, high resolution mass spectrometry and off-line NMR
Keywords: HLM، میکروزوم های کبدی انسان; HRS, high resolution screening; HTS, high throughput screening; RAD, receptor affinity detection; hER, human estrogen receptor ligand binding domain; NET, norethisterone; IT-TOF, ion trap-time of flight; CYPs, cytochrome P450s; HLM, human liver microsomes
Characterisation and identification of the human N+-glucuronide metabolite of cediranib
Keywords: HLM، میکروزوم های کبدی انسان; HLM, human liver microsomes; HPLC–MS, high performance liquid chromatography–mass spectrometry; UGT, uridine glucuronosyl transferase; UDPGA, uridine diphosphate glucuronic acid; NMR, Nuclear Magnetic Resonance Spectroscopy; NOE, nuclear Overhauser effect
Metabolic activation of the phenothiazine antipsychotics chlorpromazine and thioridazine to electrophilic iminoquinone species in human liver microsomes and recombinant P450s
Keywords: HLM، میکروزوم های کبدی انسان; P450, cytochrome P450; CPZ-SG, chlorpromazine GSH conjugate; TDZ-SG, thioridazine GSH conjugate; PI, precursor ion; EPI, enhanced product ion; HLM, human liver microsomes; GSH, glutathioneBioactivation; Reactive metabolites; Chlorpromazine; Thioridazine;
The monoterpenoids citral and geraniol are moderate inhibitors of CYP2B6 hydroxylase activity
Keywords: HLM، میکروزوم های کبدی انسان; P450, cytochrome P450; HLM, human liver microsomes; LC/MS/MS, liquid chromatography/tandem mass spectrometryMonoterpenoids; Inhibition; CYP2B6; Bupropion; Citral; Geraniol
Bioactivation of the tricyclic antidepressant amitriptyline and its metabolite nortriptyline to arene oxide intermediates in human liver microsomes and recombinant P450s
Keywords: HLM، میکروزوم های کبدی انسان; P450, cytochrome P450; TCAs, tricyclic antidepressants; PI, precursor ion; EPI, enhanced product ion; HLM, human liver microsomes; GSH, glutathioneAmitriptyline; Nortriptyline; Bioactivation; P450; Hepatotoxicity; Arene oxide
The participation of human hepatic P450 isoforms, flavin-containing monooxygenases and aldehyde oxidase in the biotransformation of the insecticide fenthion
Keywords: HLM، میکروزوم های کبدی انسان; OPTs, organophosphotohionate pesticides; CYPs, cytochrome P450 isoforms; FMOs, flavin-containing monooxygenase; HLM, human liver microsomes; HLC, human liver cytosols; AO, aldehyde oxidase; FEN, fenthion; FOX, fenthion-oxon; CLi, intrinsic clearance; AChE
Identification of human UDP-glucuronosyltransferases catalyzing hepatic 1α,25-dihydroxyvitamin D3 conjugation
Keywords: HLM، میکروزوم های کبدی انسان; 1,25(OH)2D3, 1α,25-dihydroxyvitamin D3; UDPGA, uridine-5′-diphosphoglucuronic acid; PTAD, 4-phenyl-1,2,4-triazoline-3,5-dione; HLM, human liver microsomes; HPLC, high performance liquid chromatography; LC/MS/MS, liquid chromatography–tandem mass spectrome
Comparison of cytochrome P450 inhibition assays for drug discovery using human liver microsomes with LC–MS, rhCYP450 isozymes with fluorescence, and double cocktail with LC–MS
Keywords: HLM، میکروزوم های کبدی انسان; ADME/TOX, absorption, distribution, metabolism and excretion/toxicity; AMMC, 3-[2-(N,N-diethyl-N-methylamino)ethyl]-7-methoxy-4-methylcoumarin; BFC, 7-benzyloxy-4-trifluoromethylcoumarin; CYP450, cytochrome P450; HLM, human liver microsomes; LC–MS, liquid
Diclofenac hydroxylation in monkeys: Efficiency, regioselectivity, and response to inhibitors
Keywords: HLM، میکروزوم های کبدی انسان; DF, diclofenac; 4′-OHD, 4′-hydroxy diclofenac; 5-OHD, 5-hydroxy diclofenac; CYPs, cytochrome P450s; Km, apparent Michaelis constant; Ks, substrate inhibition constant; Vmax, maximal velocity; HLM, human liver microsomes; Rh-MLM, rhesus monkey liver micros
Diazinon, chlorpyrifos and parathion are metabolised by multiple cytochromes P450 in human liver
Keywords: HLM، میکروزوم های کبدی انسان; HLM, human liver microsomes; IHMP, pyrimidinol; PNPp-nitrophenol; TCP, trichloro-2-pyridinolHuman liver; Organophosphate pesticides; Human CYPs; Metabolism