
Diminished toxicity of C-1748, 4-methyl-9-hydroxyethylamino-1-nitroacridine, compared with its demethyl analog, C-857, corresponds to its resistance to metabolism in HepG2 cells
Keywords: DTT; dithiothreitol; HLM; human liver microsomes; HRN; Hepatic Reductase Null mouse; POR; NADPH-P450 oxidoreductase; RLM; rat liver microsomes; WT; wild type; Antitumour agents; Capridine β; C-1748; Hypoxia; Metabolism; 1-Nitroacridines;