
Biochemical and biological evaluation of novel potent coumarin inhibitor of 17β-HSD type 1
Keywords: HSD, hydroxysteroid dehydrogenase; E1, estrone; E2, 17β-estradiol; ER, estrogen receptor; NAD(P)(H), nicotine amide dinucleotide (phosphate) (reduced form); SAR, structure–activity relationship17β-HSD type 1; Soluble recombinant enzyme; Hormone-dependent